Results 151 to 160 of about 3,939 (188)

Regulation of the Proinflammatory Effects of Fas Ligand (CD95L)

Science, 1998
Fas ligand (CD95L) inhibits T cell function in immune-privileged organs such as the eye and testis, yet in most tissues CD95L expression induces potent inflammatory responses. With a stably transfected colon carcinoma cell line, CT26-CD95L, the molecular basis for these divergent responses was defined.
J J, Chen, Y, Sun, G J, Nabel
openaire   +2 more sources

The CD95(APO-1/Fas)/CD95L system

Toxicology Letters, 1998
The CD95 system is one of the best studied death systems and plays an essential role in the immune system, particularly in deletion of peripheral T-cells and in homeostasis of the liver. Here genetic defects in the CD95 system are discussed as well as recent findings of the CD95 signalling pathway.
openaire   +2 more sources

Atypical Immune Functions of CD95/CD95L

2017
The receptor CD95 (also named Fas or APO-1) is a member of the tumor necrosis factor receptor (TNF-R) superfamily. Its cognate ligand, CD95L, is implicated in immune homeostasis and immune surveillance. Mutations of this receptor or its ligand lead to autoimmune disorders such as systemic lupus erythematosus (SLE) and to cancers; hence, CD95 and CD95L ...
Amanda Poissonnier, Patrick Legembre
openaire   +1 more source

Expression of Fas (CD95) and FasL (CD95L) in Human Airway Epithelium

American Journal of Respiratory Cell and Molecular Biology, 1998
Abstract The cell surface molecule Fas (CD95) is a member of the tumor necrosis factor receptor family. Ligation of the Fas receptor can lead to induction of apoptosis in inflammatory cells. It has been suggested that expression of the Fas receptor and its ligand (FasL) in airway epithelium may modulate the inflammatory response ...
K J, Hamann, D R, Dorscheid, F D, Ko, A E, Conforti, A I, Sperling, K F, Rabe, S R, White   +6 more
openaire   +2 more sources

Effects of Daunorubicin and CD95L on Retinal Function in Superfused Vertebrate Retina

Journal of Ocular Pharmacology and Therapeutics, 2005
Alternative treatments of proliferative vitreoretinopathy (PVR) are needed. The intravitreal application of daunorubicin combined with CD95 ligand (CD95L) could provide a new therapeutic strategy. The effects of this application on bovine retinal function were investigated.
Arno, Hueber, Matthias, Lüke, Peter J, Esser, Bernd, Kirchhof, Werner, Sickel, Christoph, Lüke   +5 more
openaire   +2 more sources

Apoptosis in neuroblastomas induced by interferon-? involves the CD95/CD95L pathway

Medical and Pediatric Oncology, 2001
The CD95/CD95 ligand (CD95L) system is a key regulator of apoptosis. To evaluate a possible role of the CD95/CD95L system in human neuroblastoma (NB) cells, we investigated the constitutive and interferongamma (INFgamma)-induced expression of CD95 and CD95L, and CD95-mediated cell death in the SK-N-BE(2) cell line.Modulation of CD95/CD95L expression ...
Annicchiarico-Petruzzelli, M., Bernassola, F., Lovat, P.E., Redfern, C.P.F., Pearson, A.D.J., Melino, G.   +11 more
openaire   +3 more sources

CD95 ligand (CD95L) in normal human lymphoid tissues: a subset of plasma cells are prominent producers of CD95L.

The American journal of pathology, 1999
CD95(Fas/APO-1)-ligand (CD95L) mediates apoptosis by trimerization of the CD95 receptor on the surface of sensitive cells. In vitro studies have shown CD95L expression mainly by activated T cells and suggested a role for CD95L in the regulation of immune responses. Little is known, however, about the cellular distribution of CD95L in situ in the normal
J, Sträter, S M, Mariani, H, Walczak, F G, Rücker, F, Leithäuser, P H, Krammer, P, Möller   +6 more
openaire   +1 more source

Potentiation of CD95L-Induced Apoptosis of Human Malignant Glioma Cells by Topotecan Involves Inhibition of RNA Synthesis but Not Changes in CD95 or CD95L Protein Expression

The Journal of Pharmacology and Experimental Therapeutics, 1998
Topotecan is a novel topoisomerase I inhibitor that may have a role in the adjuvant chemotherapy of several solid tumors, including malignant glioma. Here, we have characterized the time- and concentration-dependent toxicity of topotecan in four human malignant glioma cell lines, LN-18, LN-229, LN-308 and T98G.
S, Winter, M, Weller
openaire   +2 more sources

Abstract 4391: CD95L mRNA is toxic to cancer cells

Cancer Research, 2018
Abstract CD95/Fas ligand (CD95L) is best characterized for its role in activating extrinsic apoptosis through binding to its receptor, CD95. However, we recently reported that the CD95L mRNA is enriched in sequences that when converted to si- or shRNAs kill cancer cells through an RNAi-dependent mechanism.
William Putzbach, Ashley Haluck-Kangas, Quan Gao, Aishe A. Sarshad, Elizabeth Bartom, Austin Stults, Abdul S. Qadir, Denise M. Scholtens, Markus Hafner, Marcus Peter   +9 more
openaire   +1 more source

CD95L/FasL and TRAIL in Tumour Surveillance and Cancer Therapy

2006
The membrane-bound death ligands CD95L/FasL and TRAIL, which activate the corresponding death receptors CD95/Fas, TRAILR1 and TRAILR2, induce apoptosis in many tumour cells, but can also elicit an inflammatory response. This chapter focuses on the relevance of CD95L/FasL and TRAIL for the tumour surveillance function of natural killer cells and ...
openaire   +2 more sources