Results 141 to 150 of about 3,939 (188)
Targeting kinases that regulate programmed cell death: a new therapeutic strategy for breast cancer. [PDF]
J Transl MedHong Y +5 more
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Designing universal T cell therapies: strategies to evade natural killer cells. [PDF]
Front ImmunolBushara O, Linette GP, Carreno BM.
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Utility of a Multimodal Biomarker Panel and Serum Proapoptotic Activity to Refine Diagnosis of Ovarian Adnexal Masses. [PDF]
DiseasesMolina-Pineda A +10 more
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Methods in Molecular Biology, 2017 The ligand of CD95, CD95L (also known as FasL or CD178), is a type II transmembrane protein that belongs to the Tumor Necrosis factor (TNF) family (Fig. 1a). This membrane-bound cytokine is mainly expressed at the surface of activated T lymphocytes and natural killer cells, where it is used as an apoptotic factor to eliminate infected and transformed ...
Sophie Martin
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CD95 Stimulation with CD95L and DISC Analysis
, 2017 CD95 and its ligand CD95L play a major role in immune surveillance and homeostasis. CD95L is expressed by activated T lymphocytes and NK cells to induce apoptosis in cancer and virus-infected cells. The goal of this chapter is to describe a method used to immunoprecipitate CD95 and analyze its associated protein complex in cells stimulated with a ...
Le Gallo, Matthieu, Legembre, Patrick
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CD95/CD95L interactions and their role in autoimmunity [PDF]
Apoptosis, 2000 CD95 (Fas/Apo-1) is a broadly expressed death receptor involved in a variety of physiological and pathological apoptotic processes. Since its discovery, defects in CD95/CD95L system have been proposed as major pathogenic factors responsible for impaired immunological tolerance to self antigens and autoimmunity. Later, analysis of altered sensitivity to
Ricci-Vitiani, L. +3 more
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CD95–CD95L: can the brain learn from the immune system?
Trends in Neurosciences, 1998Members of the tumor necrosis factor/nerve growth factor receptor superfamily of cell-surface molecules can play the dual role of mediating either cytotoxicity or cell survival, both in the immune system and in the nervous system. A member of this superfamily, CD95 (also known as ApoI or Fas), was initially identified in the immune system and has been ...
Trevor Owens +2 more
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Extracellular matrix interacts with soluble CD95L: Retention and enhancement of cytotoxicity
Nature Immunology, 2001Fas ligand (CD95L) is synthesized both on the cell surface membrane and in a soluble form. Although CD95L contributes to immune privilege in the cornea and testis, the functions of these alternatively processed proteins are not well understood. Some reports suggest that the cytotoxicity of soluble CD95L is insignificant, whereas others show potent ...
Kazunori Aoki +2 more
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Proapoptotic CD95L levels in normal human serum and sera of breast cancer patients
Tumor Biology, 2015 The CD95 pathway is a critical apoptotic pathway used by immune cells to avoid cancer development. CD95 ligand (CD95L) is found in several forms, as a cell membrane-associated form, a soluble metalloprotease-cleaved form, and a soluble but membrane-bound
Luis Felipe Jave-Suarez +2 more
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Tumor expression of Fas ligand (CD95L) and the consequences
Current Opinion in Immunology, 1998Tumors of diverse origin have recently been shown to express CD95 ligand and to induce apoptosis in CD95-expressing targets in vitro; however, in vivo, enhanced tumor growth and rejection have both been observed as a consequence of either immunosuppressive or proinflammatory functions of CD95 ligand.
Walker PR, Saas P, Dietrich PY
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