Results 91 to 100 of about 1,680,486 (323)

A model for the differentiation of human natural killer cells. Studies on the in vitro activation of Leu-11+ granular lymphocytes with a natural killer-sensitive tumor cell, K562. [PDF]

, 1985
A subpopulation of low density granular lymphocytes that express the natural killer (NK) cell-associated Leu-11 antigen (IgG Fc receptor) were stimulated directly by coculture with an NK-sensitive tumor cell, K562.
Lanier, LL, Phillips, JH
core  

Investigating the potential impact of post translational modification of auto-antigens by tissue transglutaminase on humoral islet autoimmunity in type 1 diabetes

Metabolism Open, 2020
Background: Post-translational modification (PTM) of antigens plays a role in the pathogenesis of many autoimmune disorders. In coeliac disease (CD), tissue transglutaminase (tTG) deamidates gliadin peptides to activate the immune response against the ...
Catherine Donnelly, Alistair Williams
doaj   +1 more source

Nanomaterial‐Enhanced Biosensing: Mechanisms and Emerging Applications

Advanced Healthcare Materials, EarlyView.
Nanomaterial integration transforms biosensor capabilities through enhanced signal transduction, sensitivity, and selectivity. This review analyzes how nanoscale materials—from nanoparticles to nanosheets—leverage unique physicochemical properties to revolutionize electrochemical, optical, and electrical biosensing.
Younghak Cho, Yunyoung Choi, Yerim Jang, Hyejeong Seong   +3 more
wiley   +1 more source

Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines [PDF]

, 2014
BackgroundPolymorphism in antigens is a common mechanism for immune evasion used by many important pathogens, and presents major challenges in vaccine development.
Anders, Robin F., Barry, Alyssa E., Beeson, James G., Cross, Nadia J., Drew, Damien R., Dutta, Sheetij, Elliott, Salenna R., Hodder, Anthony N., Marsh, Kevin, Mueller, Ivo, Mugyenyi, Cleopatra K., Osier, Faith, Richards, Jack S., Senn, Nicolas, Siba, Peter M., Stanisic, Danielle I., Terheggen, Ulrich   +16 more
core   +1 more source

Novel Bioconjugate Materials: Synthesis, Characterization and Medical Applications

Advanced Healthcare Materials, EarlyView.
This review discusses the bioconjugation of novel materials grouped under “biological”, “hybrid” and “synthetic” categories. Medical applications ranging from cancer therapy and diagnostics to optogenetics and tissue engineering are explored, and conjugation trends are highlighted as a general guide. The review concludes with a comparison of techniques
Ellie Martin, Sean P. Doidge, Eiman Aleem, Suela Kellici, Steven Dunn, Claire Atkinson, Philip D. Howes   +6 more
wiley   +1 more source

Simultaneous expression of CD4 and CD8 antigens by a substantial proportion of resting porcine T lymphocytes [PDF]

, 1987
The existence of four subpopulations in resting porcine T lymphocytes is documented. In addition to the two known subpopulations which are typified by a mutually exclusive expression of either the CD8 or the CD4 differentiation antigen, CD4-CD8+ and CD4 ...
Bevan, Bielefeldt Ohmann, Blue, Blue, Davignon, Fazekas de St. Groth, Goverman, Jonjić, Lanier, Lanier, MacDonald, Mackay, Pescovitz, Pescovitz, Reinherz, Reinherz, Saalmüller, Scollay, Swain, Tumbleson   +19 more
core   +3 more sources

A Novel Brain Penetrable Nanocarrier Delivers Brain‐Derived Neurotrophic Factor to Treat Alzheimer's Disease

Advanced Healthcare Materials, EarlyView.
A novel blood‐brain barrier‐penetrating terpolymer nanoparticle to deliver brain‐derived neurotrophic factor (BDNF) for the treatment of Alzheimer's disease (AD) is designed. The BDNF‐TPN significantly enhances BDNF accumulation in the brain following intravenous injection, reduces apoptosis and neuroinflammation, thus promoting neuronal survival and ...
Lily Yi Li, Elliya Park, Chunsheng He, Azhar Z. Abbasi, Pei Zhi, Paul E. Fraser, Andrew M. Rauth, Jeffery T. Henderson, Xiao Yu Wu   +8 more
wiley   +1 more source

Mechanisms by Which Dendritic Cells Present Tumor Microparticle Antigens to CD8+ T Cells

Cancer immunology research, 2018
Tumor-derived microparticles activate a lysosomal pathway enabling dendritic cell upregulation of costimulatory molecules and presentation of tumor antigens to CD+ T cells.
Jingwei Ma, Keke Wei, Huafeng Zhang, K. Tang, Fei Li, Tianzhen Zhang, Junwei Liu, P. Xu, Yuandong Yu, Weiwei Sun, Liyan Zhu, Jie Chen, Li Zhou, Xiaoyu Liang, Jiadi Lv, R. Fiskesund, Yuying Liu, Bo Huang   +17 more
semanticscholar   +1 more source

FTY720 (fingolimod) modulates the severity of viral-induced encephalomyelitis and demyelination. [PDF]

, 2014
BackgroundFTY720 (fingolimod) is the first oral drug approved by the Food and Drug Administration for treatment of patients with the relapsing-remitting form of the human demyelinating disease multiple sclerosis.
Blanc, Caroline A, Lane, Thomas E, Rosen, Hugh   +2 more
core   +1 more source

Myeloperoxidase Luminol Reaction – A Novel Faecal Assay for Predicting Colonoscopy Findings in Patients with Ulcerative Colitis: A Pilot Cross‐Sectional Clinical Study

Advanced Healthcare Materials, EarlyView.
Can luminol detect faecal inflammation? This study explores the development and optimisation of a rapid novel assay ‐ Myeloperoxidase Luminol Reaction (MPOLR) for the detection of faecal myeloperoxidase activity. This simple and rapid luminol‐based approach competes with clinically validated faecal biomarkers in predicting endoscopic findings in ...
Viraj Kariyawasam, Taylor Davis, Mark Ghali, David Tejcek, Thomas R O'Neil, Ella Verley, Matthew Griffiths, Miguel Campos, Ingrid Bonney, Andrew C. Bulmer, Yogambha Ramaswamy, Nikola Mitrev, Crispin Corte, Paul K. Witting, Belal Chami   +14 more
wiley   +1 more source