Results 141 to 150 of about 531,349 (289)
Down-regulatory mechanism of mammea E/BB from Mammea siamensis seed extract on Wilms' Tumor 1 expression in K562 cells. [PDF]
, 2016 BackgroundWilms' tumor 1 (WT1) is a biological marker for predicting leukemia progression. In this study, mammea E/BB, an active compound from Saraphi (Mammea siamensis) seed extract was examined for its effect on down-regulatory mechanism of WT1 gene ...
Ampasavate, Chadarat +6 more
core +1 more source
Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.
PLoS ONE, 2019 The discovery of 20 unconventional kinetochore proteins in Trypanosoma brucei has opened a new and interesting area of evolutionary research to study a biological process previously thought to be highly conserved in all eukaryotes.
Leah S Torrie +5 more
doaj +1 more source
MD and EPR studies of the structure and dynamics of the MTSL spin-labelled activation loop of the Aurora-A kinase [PDF]
arXiv, 2015 The understanding of kinase structure is mostly based on protein crystallography, which is limited by the requirement to trap molecules within a crystal lattice. Therefore, characterisations of the conformational dynamics of the activation loop in solution are important to enhance the understanding of molecular processes related to diseases and to ...
arxiv
Signalling cell cycle arrest and cell death through the MMR System [PDF]
, 2006 Loss of DNA mismatch repair (MMR) in mammalian cells, as well as having a causative role in cancer, has been linked to resistance to certain DNA damaging agents including clinically important cytotoxic chemotherapeutics.
Brown, R., O'Brien, V.
core +1 more source
PLoS ONE, 2013 The protozoan parasite, Trypanosoma brucei, is spread by the tsetse fly and causes trypanosomiasis in humans and animals. Both the life cycle and cell cycle of the parasite are complex. Trypanosomes have eleven cdc2-related kinases (CRKs) and ten cyclins,
Séverine Monnerat +9 more
doaj +1 more source
Journal of Biological Chemistry, 1997 Human single-stranded DNA-binding protein (HSSB, also called RPA), is a heterotrimeric complex that consists of three subunits, p70, p34, and p11. HSSB is essential for the in vitro replication of SV40 DNA and nucleotide excision repair.
H. Niu +5 more
semanticscholar +1 more source
Stress activated protein kinase pathway modulates homologous recombination in fission yeast.
PLoS ONE, 2012 Rad52 is a key player in homologous recombination (HR), a DNA repair pathway that is dedicated to double strand breaks repair and recovery of perturbed replication forks.
Angela Bellini +5 more
doaj +1 more source
Latent periodicity of serine-threonine and tyrosine protein kinases and another protein families [PDF]
Molekularnuya Biologiya (Russian), vol.39, N3, 2005, 2004 We identified latent periodicity in catalytic domains of approximately 85% of serine/threonine and tyrosine protein kinases. Similar results were obtained for other 22 protein domains. We also designed the method of noise decomposition, which is aimed to distinguish between different periodicity types of the same period length. The method is to be used
arxiv
Phosphorylation by Neuronal cdc2-like Protein Kinase Promotes Dimerization of Tau Protein in Vitro *
Journal of Biological Chemistry, 1997 In Alzheimer’s disease, the microtubule-associated protein tau forms paired helical filaments (PHFs) that are the major structural component of neurofibrillary tangles.
H. Paudel
semanticscholar +1 more source
Journal of Biological Chemistry, 2001 Protein phosphatase 1 (PP1) is complexed with inhibitor 2 (I-2) in the cytosol. In rabbit muscle extract PP1·I-2 is activated upon preincubation with ATP/Mg. This activation is caused by phosphorylation of I-2 on Thr72 by glycogen synthase kinase 3 (GSK3)
A. Agarwal-Mawal, H. Paudel
semanticscholar +1 more source