Results 171 to 180 of about 531,349 (289)

Escherichia coli cytolethal distending toxin blocks the HeLa cell cycle at the G2/M transition by preventing cdc2 protein kinase dephosphorylation and activation

Infection and Immunity, 1997
C. Comayras, C. Tasca, Sylvie Y. Pérès, B. Ducommun, É. Oswald, J. D. Rycke   +5 more
semanticscholar   +1 more source

Membrane repair against H. pylori promotes cancer cell proliferation [PDF]

, 2010
Membrane repair is a universal response against physical and biological insults and enables cell survival. Helicobacter pylori is one of the most common human pathogens and the first formally recognized bacterial carcinogen associated with gastric cancer.
Chiung-Nien Chen, Hsuan-Cheng Huang, Hsueh-Fen Juan, Jin-Town Wang, Li-Ling Lin, Satoshi Ogihara   +5 more
core   +1 more source

Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations [PDF]

arXiv
The intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for ...
arxiv  

Targeting the CLK2/SRSF9 splicing axis in prostate cancer leads to decreased ARV7 expression

Molecular Oncology
In advanced prostate cancer (PC), in particular after acquisition of resistance to androgen receptor (AR) signaling inhibitors (ARSI), upregulation of AR splice variants compromises endocrine therapy efficiency.
Jasper Van Goubergen, Miroslav Peřina, Florian Handle, Elisa Morales, Anika Kremer, Oliver Schmidt, Glen Kristiansen, Marcus V. Cronauer, Frédéric R. Santer   +8 more
doaj   +1 more source

A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites

Molecular and Cellular Biology, 1993
M. J. Marcote, D. Knighton, G. Basi, J. Sowadski, Paolo Brambilla, Giulio Draetta, Susan S. Taylor   +6 more
semanticscholar   +1 more source

Molecule Generation for Target Protein Binding with Hierarchical Consistency Diffusion Model [PDF]

arXiv
Effective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models for 3D molecular generation, current methods often struggle with validity and reliability.
arxiv  

Conservation of function and regulation within the Cdc28/cdc2 protein kinase family: characterization of the human Cdc2Hs protein kinase in Saccharomyces cerevisiae

Molecular and Cellular Biology, 1989
C. Wittenberg, S. Reed
semanticscholar   +1 more source

PhosNetVis: a web-based tool for fast kinase-substrate enrichment analysis and interactive 2D/3D network visualizations of phosphoproteomics data [PDF]

arXiv
Protein phosphorylation involves the reversible modification of a protein (substrate) residue by another protein (kinase). Liquid chromatography-mass spectrometry studies are rapidly generating massive protein phosphorylation datasets across multiple conditions.
arxiv  

Entwicklung und Validierung eines Bioassays zum Nachweis induzierter Genaktivität für den Einsatz auf der Internationalen Raumstation [PDF]

, 2007
Neben der fehlenden Schwerkraft stellt die Strahlenbelastung des Astronauten einen limitierenden Faktor für den Langzeitaufenthalt des Menschen im Weltraum dar.
Arenz, Andrea
core  

Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.

EMBO Journal, 1987
R. Booher, D. Beach
semanticscholar   +1 more source