Results 181 to 190 of about 4,659,967 (205)
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Downregulation of the cdc2/Cyclin B Protein Kinase Activity by Binding of p53 to p34cdc2
Biochemical and Biophysical Research Communications, 2001We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity.
M, Ababneh, C, Götz, M, Montenarh
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Identification of a Novel Drosophila Gene Encoding a Cdc2-Related Protein Kinase.
Journal of Biochemistry, 1994We have identified a novel gene encoding a putative protein kinase from a Drosophila genomic library. The gene, about 2 kbp in length, consists of four exons and codes for a protein of 349 amino acid residues. The deduced sequence shows significant similarity to various kinases, especially to a subgroup of Ser/Thr kinases related to Cdc2 kinase; thus ...
Yasufumi Emori +2 more
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Reviews in Medical Virology, 2003
AbstractHerpesviruses encode protein kinases. A subset of these proteins, represented by HSV‐1 UL13, are conserved throughout all members of the Herpesviridae, and here, are designated CHPKs (conserved herpesvirus protein kinases). In addition to conserved gene products like CHPKs, herpesviruses encode genes specific to respective herpesviruses.
Yasushi, Kawaguchi, Kentaro, Kato
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AbstractHerpesviruses encode protein kinases. A subset of these proteins, represented by HSV‐1 UL13, are conserved throughout all members of the Herpesviridae, and here, are designated CHPKs (conserved herpesvirus protein kinases). In addition to conserved gene products like CHPKs, herpesviruses encode genes specific to respective herpesviruses.
Yasushi, Kawaguchi, Kentaro, Kato
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Biochemical Regulation of the CDC2 Protein Kinase
1991cdc21 and its homolog CDC28, are 34 kd protein kinases originally identified in the yeasts S. pombe and S. cerevisiae, respectively (for review see (Cross et al., 1989) (Nurse, 1990). In these organisms, mutations in cdc2/28 arrest cells in either the G1 or the G2 phases of the cell cycle.
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Biology of the Cell, 1990
Summary—Among protein serine/threonine kinases, the CDC2 proteins are both well characterized as protein serine/threonine kinases and are functionally involved in the control of cell division. Protein serine/threonine kinase sequences were analysed using Fourier transform of the coded sequences. Characteristic code/frequency pairs were extracted from a
Robert Bellé, Marie-Anne Guerrucci
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Summary—Among protein serine/threonine kinases, the CDC2 proteins are both well characterized as protein serine/threonine kinases and are functionally involved in the control of cell division. Protein serine/threonine kinase sequences were analysed using Fourier transform of the coded sequences. Characteristic code/frequency pairs were extracted from a
Robert Bellé, Marie-Anne Guerrucci
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PISSLRE, a human novel CDC2-related protein kinase.
Oncogene, 1994The cell division cycle have been shown to be regulated by a closely-related family of protein kinases named CDKs (by cyclin-dependent kinases). Using a PCR-based cloning technique, we have isolated cDNAs encoding a human CDC2-related protein kinase. The full-length cDNA accommodates an open reading frame that does not contain any ATG initiation codon ...
GRANA X +4 more
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Investigation of CDC2-independent mitotic protein kinases
2009Mitosis is a highly coordinated event which ensures the equal segregation of the cytoplasmic and genetic material into two daughter cells. A key regulatory process in ensuring the temporal fidelity of mitosis involves reversible protein phosphorylation mediated by protein kinases and phosphatases.
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cdc2-related protein kinases and cell cycle control in trypanosomatids
Parasitology Today, 1994The molecular mechanisms that control the cell cycle have been studied extensively in yeast and higher eukaryotes. Investigations have centred on the cyclin-dependent kinase family of serine/threonine protein kinases, the best characterized of which is cdc2, a key regulatory element in the control of mitosis.
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cdc2-like kinase is associated with the retinoblastoma protein.
Oncogene, 1992The growth-suppressive activity of the retinoblastoma (RB) protein is suggested to be regulated by phosphorylation. In studies on the kinase that phosphorylates the RB proteins, we have previously found that RB proteins can be phosphorylated by purified cdc2 kinase. In this study, we noted that RB proteins immunoprecipitated from human cell lysates are
M, Kitagawa +9 more
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cdc2 protein kinase: structure-function relationships.
Ciba Foundation symposium, 1993Activation of the cdc2 kinase in the cell cycle occurs upon binding to a regulatory subunit called cyclin. Cyclin A associates with both Cdc2 and its homologue Cdk2. The two complexes appear in S phase but cyclin A/Cdk2 is activated earlier than cyclin A/Cdc2. Several regions in Cdc2 are involved in binding cyclins A and B.
M J, Marcote, M, Pagano, G, Draetta
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