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The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells
Cell, 1989A homolog of the fission yeast cdc2-encoded protein kinase (p34) is a component of M phase promoting factor in Xenopus oocytes. The homologous kinase in human HeLa cells is maximally active during mitosis, suggesting a mitotic role in mammalian somatic cells.
K, Riabowol +4 more
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Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases
Archives of Insect Biochemistry and Physiology, 2002AbstractMutations in the canoe locus of Drosophila lead to failure in the dorsal closure of the embryonic epidermis and pattern formation defects in imaginal eyes and wings. In the wing, the canoe mutants develop extra veins when they are heterozygous for shaggy, a mutation in the locus encoding the glycogen synthase kinase 3β (Gsk3β), which has been ...
Kuniaki, Takahashi +2 more
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Downregulation of the cdc2/Cyclin B Protein Kinase Activity by Binding of p53 to p34cdc2
Biochemical and Biophysical Research Communications, 2001We previously found that p53 binds to the catalytic subunit of the p34(cdc2)/cyclin B1-kinase. In the present study we analyzed the functional consequences of this interaction. Binding of wild-type p53 to p34(cdc2)/cyclin B1 results in a significant decrease of its histone H1 kinase activity.
M, Ababneh, C, Götz, M, Montenarh
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Biochemical Regulation of the CDC2 Protein Kinase
1991cdc21 and its homolog CDC28, are 34 kd protein kinases originally identified in the yeasts S. pombe and S. cerevisiae, respectively (for review see (Cross et al., 1989) (Nurse, 1990). In these organisms, mutations in cdc2/28 arrest cells in either the G1 or the G2 phases of the cell cycle.
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Reviews in Medical Virology, 2003
AbstractHerpesviruses encode protein kinases. A subset of these proteins, represented by HSV‐1 UL13, are conserved throughout all members of the Herpesviridae, and here, are designated CHPKs (conserved herpesvirus protein kinases). In addition to conserved gene products like CHPKs, herpesviruses encode genes specific to respective herpesviruses.
Yasushi, Kawaguchi, Kentaro, Kato
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AbstractHerpesviruses encode protein kinases. A subset of these proteins, represented by HSV‐1 UL13, are conserved throughout all members of the Herpesviridae, and here, are designated CHPKs (conserved herpesvirus protein kinases). In addition to conserved gene products like CHPKs, herpesviruses encode genes specific to respective herpesviruses.
Yasushi, Kawaguchi, Kentaro, Kato
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PISSLRE, a human novel CDC2-related protein kinase.
Oncogene, 1994The cell division cycle have been shown to be regulated by a closely-related family of protein kinases named CDKs (by cyclin-dependent kinases). Using a PCR-based cloning technique, we have isolated cDNAs encoding a human CDC2-related protein kinase. The full-length cDNA accommodates an open reading frame that does not contain any ATG initiation codon ...
GRANA X +4 more
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cdc2-related protein kinases and cell cycle control in trypanosomatids
Parasitology Today, 1994The molecular mechanisms that control the cell cycle have been studied extensively in yeast and higher eukaryotes. Investigations have centred on the cyclin-dependent kinase family of serine/threonine protein kinases, the best characterized of which is cdc2, a key regulatory element in the control of mitosis.
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The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle
Journal of Cell Science, 1989ABSTRACT Recent experimental evidence has demonstrated the central role of the cdc2 protein kinase in the transition from G2 to M phase in eukaryotic cells. We shall review our knowledge of the mechanisms which coordinate activation of the kinase with cell cycle-specific events in mammalian cells.
G, Draetta, D, Beach
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Investigation of CDC2-independent mitotic protein kinases
2009Mitosis is a highly coordinated event which ensures the equal segregation of the cytoplasmic and genetic material into two daughter cells. A key regulatory process in ensuring the temporal fidelity of mitosis involves reversible protein phosphorylation mediated by protein kinases and phosphatases.
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cdc2-like kinase is associated with the retinoblastoma protein.
Oncogene, 1992The growth-suppressive activity of the retinoblastoma (RB) protein is suggested to be regulated by phosphorylation. In studies on the kinase that phosphorylates the RB proteins, we have previously found that RB proteins can be phosphorylated by purified cdc2 kinase. In this study, we noted that RB proteins immunoprecipitated from human cell lysates are
M, Kitagawa +9 more
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