Results 171 to 180 of about 4,659,967 (205)
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Structure, Function, and Regulation of Neuronal Cdc2-Like Protein Kinase
Neurobiology of Aging, 1995We have identified and purified from bovine brain a novel protein kinase which catalyzes in vitro phosphorylation of neurofilament proteins NF-H and NF-M and tau proteins at sites implicating the enzyme in the regulation of neurocytoskeleton dynamics and in Alzheimer pathology.
Robert Z. Qi, J Lew, Masayuki Matsushita
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Cell, 1989 The products of the cdc13+ and cdc2+ genes form a stable complex that displays protein kinase activity in vitro. p63cdc13 is a substrate of p34cdc2, the catalytic subunit of the kinase.
Jeremy S. Hyams, C E Alfa, David H Beach
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A Novel cdc2-Related Protein Kinase Expressed in the Nervous System [PDF]
Journal of Neurochemistry, 1997 Abstract: We report the cloning and characterization of a cDNA encoding a cdc2‐related protein kinase, named PFTAIRE, that is expressed primarily in the postnatal and adult nervous system. We have demonstrated by in situ hybridization and indirect immunofluorescence that several populations of terminally differentiated neurons and some neuroglia ...
Paul R. Albert +2 more
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A family of trypanosome cdc2-related protein kinases
Gene, 1995The cyclin-dependent kinases, most notable of which is cdc2, are key regulators of the cell cycle, and are highly conserved in evolution. We have cloned and analysed three cdc2-related kinase-encoding genes (tbcrk1-3) from the protozoan parasite Trypanosoma brucei.
J C, Mottram, G, Smith
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Molecular Genetics and Genomics, 1989 The cdc2+ gene function plays a central role in the control of the mitotic cell cycle of the fission yeast Schizosaccharomyces pombe. Recessive temperature-sensitive mutations in the cdc2 gene cause cell cycle arrest when shifted to the restrictive ...
Stuart A. MacNeill +2 more
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Activation of the various cyclin/cdc2 protein kinases
Current Opinion in Cell Biology, 1993Recent research has led to the near culmination of the biochemical confirmation of the most basic genetic predictions about how p34cdc2 activity is controlled. The field is now moving from a biochemical dissection of the machinery to understanding how the system is regulated.
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Regulation of the Mitotic CDC2 Protein Kinase
1993The eukaryotic cell cycle is characterized by two major events, DNA replication (S phase) and mitosis (M phase); these are separated by two so-called “gap”-phases, G1 (prior to S phase) and G2 (prior to M phase). According to the current paradigm of the cell cycle as a “cdc2 cycle”, both DNA replication and mitosis are driven by serine-threonine ...
E. A. Nigg, W. Krek, P. Gallant
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Identification of Major Nucleolar Proteins as Candidate Mitotic Substrates of cdc2 Kinase
Cell, 1990Following the identification of the cdc2 kinase as a major element controlling entry of cells into mitosis, it is important to define the physiological target range of this enzyme. Here, we demonstrate that two major nucleolar proteins, nucleolin and NO38, are highly phosphorylated during mitosis.
Erich Nigg, E A Nigg, Marcel Dorée
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The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells
Cell, 1989A homolog of the fission yeast cdc2-encoded protein kinase (p34) is a component of M phase promoting factor in Xenopus oocytes. The homologous kinase in human HeLa cells is maximally active during mitosis, suggesting a mitotic role in mammalian somatic cells.
K, Riabowol +4 more
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Ras target protein canoe is a substrate for Cdc2 and Cdk5 kinases
Archives of Insect Biochemistry and Physiology, 2002AbstractMutations in the canoe locus of Drosophila lead to failure in the dorsal closure of the embryonic epidermis and pattern formation defects in imaginal eyes and wings. In the wing, the canoe mutants develop extra veins when they are heterozygous for shaggy, a mutation in the locus encoding the glycogen synthase kinase 3β (Gsk3β), which has been ...
Kuniaki, Takahashi +2 more
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