Results 171 to 180 of about 3,589,787 (212)

The Effect of AZD5153 on Radiosensitivity in Pancreatic Cancer Cells Through ATM-chk1 Pathway. [PDF]

Drug Des Devel Ther
Zhu L, Dong R, Yan G, Zhu H, Yan Y, Zhang B, Wang G, Lin N, Tan B.   +8 more
europepmc   +1 more source

Thymic APC Networks Orchestrate T-Cell Selection: Mechanisms and Therapeutic Opportunities in Immune Disorders. [PDF]

Immunology
Luo Y, Wang W, Yan J.
europepmc   +1 more source

Combining network pharmacology and experimental validation to study the action and mechanism of brusatol against lung adenocarcinoma. [PDF]

Sci Rep
Jin X, Yang S, Pan D, Jin B, Zhang Y, Yang C.   +5 more
europepmc   +1 more source

Regulation of cell proliferation by a novel feedback system on Cdk function

Ryan JC, Leray B, Jain A, Coehlo N, Domingo-Sananes MR, Aspert T, Charvin G, Krockenberger MS, Chica Blaguera N, Lopez Aviles S, Takacs L, Uhlmann F, Yang L, Yue J, Liti G, Cochard V, Chevreux G, Sugiyama H, Goto Y, Aoki K, Wu PJ, Mackereth C, Tyson J, Novák B, Coudreuse D.   +24 more
europepmc   +1 more source

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Nature, 1988
cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation.
Thomas Roberts, Giulio Draetta, D Beach   +2 more
exaly   +4 more sources

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Structure, function, and regulation of neuronal Cdc2-like protein kinase

Neurobiology of Aging, 1995
We have identified and purified from bovine brain a novel protein kinase which catalyzes in vitro phosphorylation of neurofilament proteins NF-H and NF-M and tau proteins at sites implicating the enzyme in the regulation of neurocytoskeleton dynamics and in Alzheimer pathology.
Jerry H Wang, J Lew, Zhong Qi
exaly   +4 more sources

Identification of a Novel Drosophila Gene Encoding a Cdc2-Related Protein Kinase

Journal of Biochemistry, 1994
We have identified a novel gene encoding a putative protein kinase from a Drosophila genomic library. The gene, about 2 kbp in length, consists of four exons and codes for a protein of 349 amino acid residues. The deduced sequence shows significant similarity to various kinases, especially to a subgroup of Ser/Thr kinases related to Cdc2 kinase; thus ...
Y Emori, S Ishimaru, Yasufumi Emori
exaly   +3 more sources

A family of trypanosome cdc2-related protein kinases

Gene, 1995
The cyclin-dependent kinases, most notable of which is cdc2, are key regulators of the cell cycle, and are highly conserved in evolution. We have cloned and analysed three cdc2-related kinase-encoding genes (tbcrk1-3) from the protozoan parasite Trypanosoma brucei.
J C, Mottram, G, Smith
openaire   +2 more sources

Activation of the various cyclin/cdc2 protein kinases

Current Opinion in Cell Biology, 1993
Recent research has led to the near culmination of the biochemical confirmation of the most basic genetic predictions about how p34cdc2 activity is controlled. The field is now moving from a biochemical dissection of the machinery to understanding how the system is regulated.
openaire   +2 more sources

Regulation of the Mitotic CDC2 Protein Kinase

1993
The eukaryotic cell cycle is characterized by two major events, DNA replication (S phase) and mitosis (M phase); these are separated by two so-called “gap”-phases, G1 (prior to S phase) and G2 (prior to M phase). According to the current paradigm of the cell cycle as a “cdc2 cycle”, both DNA replication and mitosis are driven by serine-threonine ...
E. A. Nigg, W. Krek, P. Gallant
openaire   +1 more source