Results 231 to 240 of about 531,349 (289)

Intracellular diffusion in the cytoplasm increases with cell size in fission yeast. [PDF]

Mol Biol Cell
Tan C, Lanz MC, Swaffer M, Skotheim J, Chang F.   +4 more
europepmc   +1 more source

Validation of a hypomorphic variant in CDK13 as the cause of CHDFIDD with autosomal recessive inheritance through determination of an episignature. [PDF]

Clin Epigenetics
Fischer J, Alders M, Mannens MMAM, Genevieve D, Hackmann K, Schröck E, Sadikovic B, Porrmann J.   +7 more
europepmc   +1 more source

Phosphatase specificity influences phosphorylation timing of CDK substrates during the cell cycle

Zeisner TU, Auchynnikava T, Nurse P.
europepmc   +1 more source

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cdc2 protein kinase: structure-function relationships.

Ciba Foundation symposium, 1992
Activation of the cdc2 kinase in the cell cycle occurs upon binding to a regulatory subunit called cyclin. Cyclin A associates with both Cdc2 and its homologue Cdk2. The two complexes appear in S phase but cyclin A/Cdk2 is activated earlier than cyclin A/
M. J. Marcote, M. Pagano, G. Draetta
semanticscholar   +4 more sources

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

Nature, 1988
cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation.
G. Draetta, H. Piwnica-Worms, D. Morrison, B. Druker, Thomas M. Roberts, D. Beach   +5 more
semanticscholar   +4 more sources

Regulation of the Mitotic CDC2 Protein Kinase

, 1993
The eukaryotic cell cycle is characterized by two major events, DNA replication (S phase) and mitosis (M phase); these are separated by two so-called “gap”-phases, G1 (prior to S phase) and G2 (prior to M phase). According to the current paradigm of the cell cycle as a “cdc2 cycle”, both DNA replication and mitosis are driven by serine-threonine ...
E. Nigg, W. Krek, P. Gallant
semanticscholar   +3 more sources

Biochemical Regulation of the CDC2 Protein Kinase

, 1991
cdc21 and its homolog CDC28, are 34 kd protein kinases originally identified in the yeasts S. pombe and S. cerevisiae, respectively (for review see (Cross et al., 1989) (Nurse, 1990). In these organisms, mutations in cdc2/28 arrest cells in either the G1 or the G2 phases of the cell cycle.
G. Draetta
semanticscholar   +3 more sources

Molecular anatomy of the CDC2 protein kinase

Cell Biology International Reports, 1990
B. Ducommun, M. Stein, G. Draetta
semanticscholar   +3 more sources