Results 51 to 60 of about 3,736 (194)

Additional file 1: of Targeting the Hsp90-Cdc37-client protein interaction to disrupt Hsp90 chaperone machinery

, 2018
The sup. Excel file for the comprehensive analysis of Hsp90-Cdc37’s client proteins. Comprehensive Analysis of Hsp90-Cdc37’s client proteins by using FunRich tool.
Ting Li (117885), Hu-Lin Jiang (234756), Yun-Guang Tong (1346100), Jin-Jian Lu (317814)   +3 more
core   +1 more source

Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B

Scientific Reports, 2022
The HSP90/CDC37 chaperone system not only assists the maturation of many protein kinases but also maintains their structural integrity after folding.
Marco Papenfuss, Svenja Lützow, Gerrit Wilms, Aaron Babendreyer, Maren Flaßhoff, Conrad Kunick, Walter Becker   +6 more
doaj   +1 more source

Specificity of the commercial anti-Cdc37 antibody and confirmation of the cell surface localization of Cdc37, using siRNA technology targeting Cdc37.

, 2012
A, B, immunofluorescence of live MDA-MB 453 and MDA-MB 231 cells respectively, using anti-Cdc37 antibody. Cells were transfected with siRNA targeting Cdc37 (shRNA Cdc37) or with plasmid DNA without any insertion (control).
Evangelia Patsavoudi (140964), Avraam El Hamidieh (140953), Nicholas Grammatikakis (140959)   +2 more
core   +1 more source

Cdc37 Promotes the Stability of Protein Kinases Cdc28 and Cak1 [PDF]

Molecular and Cellular Biology, 2000
In the budding yeast Saccharomyces cerevisiae, Cdc37 is required for the productive formation of Cdc28-cyclin complexes. The cdc37-1 mutant arrests at Start with low levels of Cdc28 protein, which is predominantly unphosphorylated at Thr169, fails to bind cyclin, and has little protein kinase activity.
A, Farrell, D O, Morgan
openaire   +2 more sources

Discovery of Novel Celastrol Derivatives as Hsp90–Cdc37 Interaction Disruptors with Antitumor Activity

, 2019
To develop novel and efficient heat shock protein 90–cell division cycle 37 (Hsp90–Cdc37) interaction disruptors, several lipophilic fragments were introduced into celastrol (CEL) to synthesize 48 new CEL derivatives.
Na Li (6550), Li Chen (5749), Zhixian Shi, Yunqing Tang, Zhixian Shi (8068175), Yunqing Tang (8068178), Zihao Zhao, Xinyue Wang, Bing Wang (126120), Jianbo Sun (1597285), Xinyue Wang (286629), Zihao Zhao (138239), Manyi Xu, Jianbo Sun, Li Chen, Manyi Xu (8068172), Na Li, Bing Wang   +17 more
core   +2 more sources

Identification of drug repurposing candidates for the treatment of polycystic kidney disease

British Journal of Pharmacology, Volume 183, Issue 16, Page 5082-5101, August 2026.
Background and Purpose Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end‐stage renal disease with limited treatment options. Drug repurposing offers a promising strategy to find effective treatments. Experimental Approach We identified birinapant, bardoxolone methyl and salicylic acid as repurposing candidates for ADPKD and
Alina Meyer, Paraskevi Sotiropoulou, Koussai Bouker, Dennis Svedberg, Rebekkah Hammar, Hester Bange, Per Larsson, André Mateus, Daniel R. Dietrich, Per Artursson   +9 more
wiley   +1 more source

Identification of co-chaperone Cdc37 in Penaeus monodon: coordination with Hsp90 can reduce cadmium stress-induced lipid peroxidation

Ecotoxicology and Environmental Safety, 2021
Cell division cycle 37 (Cdc37) is an important cytoplasmic phosphoprotein, which usually functions as a complex with heat shock protein 90 (Hsp90), to effectively reduce the damage caused by heavy metals, such as cadmium (Cd), in aquatic animals.
Chao Zhao, Chao Peng, Pengfei Wang, Sigang Fan, Lulu Yan, Lihua Qiu   +5 more
doaj   +1 more source

ITC data for CDC37-BRAF interactions for paper: Recognition of BRAF by CDC37 and Re-evaluation of the Activation mechanism for the Class 2 BRAF-L597R Mutant

, 2022
Data for paper published in Biomolecules June 2022  Isothermal Titration Calorimetry results for CDC37-BRAF interactions. dil in the filename donates the heat of dilution. Heats of dilution are in to buffer.
Dennis Bjorklund (6517310), Jasmeen Oberoi (4466683), Rhodri M. L. Morgan (106004), Panagiota A Galliou (12914434), Chrisostomos Prodromou (4463035), Katie L.I.M. Day (12914441)   +5 more
core   +1 more source

Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2. [PDF]

PLoS ONE, 2013
AKT2 is one of the three isoforms of the protein kinase AKT being involved in the modulation of cellular metabolism. Since protein-protein interactions are one possibility to convey specificity in signal transduction, we performed AKT2-protein ...
Katharina Bottermann, Michael Reinartz, Marian Barsoum, Sebastian Kötter, Axel Gödecke   +4 more
doaj   +1 more source

Extracellular Vesicles in Head and Neck Cancer—A Systematic Review

Journal of Extracellular Biology, Volume 5, Issue 7, July 2026.
ABSTRACT Head and neck cancer (HNC) is among the top ten malignancies worldwide and is associated with high morbidity and mortality. Oral potentially malignant disorders (OPMDs) predispose to certain HNCs. Recent studies suggest emerging roles of extracellular vesicles (EVs) in malignant transformation and provide potential in the management of HNC ...
Abdallah Swaid, Nadisha Piyarathne, Andrea Holme, David Muirhead, Gabriel Landini, Rasha Abu‐Eid   +5 more
wiley   +1 more source