Results 71 to 80 of about 3,736 (194)

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target

Aging Cell, Volume 25, Issue 3, March 2026.
By a global proteomic profiling of senescent human BJ fibroblasts induced by ionizing radiation, key cellular features required for the survival of senescent fibroblasts were revealed, and pyruvate dehydrogenase was demonstrated as a potent senolytic target for selectively eliminating senescent normal cells, particularly the therapy‐induced senescent ...
Mingzhu Zhang, Ziqi Hu, Shengwen Piao, Yingrui Song, Ying Jia, Jiaxing Liu, Ning Zhao, An Liu, Songbin Fu, Wenjing Sun, Hui Xu, Yu Yang, Steven P. Gygi, Chunshui Zhou   +13 more
wiley   +1 more source

Nematode CDC-37 and DNJ-13 form complexes and can interact with HSP-90

Scientific Reports, 2021
The molecular chaperones Hsc70 and Hsp90 are required for proteostasis control and specific folding of client proteins in eukaryotic and prokaryotic organisms.
Lukas Schmauder, Eva Absmeier, Alexander Bepperling, Katalin Barkovits, Katrin Marcus, Klaus Richter   +5 more
doaj   +1 more source

Conformational Mobility Profiling of the Hsp90-Cdc37 Complex.

, 2014
The NMSF profile of the Hsp90-Cdc37 complex (A) was obtained using the NMR structure (PDB ID 2K5B) of the complex between human Cdc37 (Cdc37-MD, original residue numbering 148–276) and human Hsp90-NTD (original residue numbering 14–223) [25]. The residue-
Kristin Blacklock (447270), Gennady M. Verkhivker (151817)   +1 more
core   +1 more source

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

Molecular Cancer, 2011
Background Multiple myeloma (MM) is a B-cell malignancy that is largely incurable and is characterized by the accumulation of malignant plasma cells in the bone marrow.
Xu Yuan-Ji, Du Zhi-Yan, Zhang Xu-Hui, Zhu Hai-Yan, Ma Jian, Zhao Ming, Yu Xiao-Dan   +6 more
doaj   +1 more source

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review comprehensively analyses the phytochemicals from Eclipta prostrata, identifying 25 active compounds with chemotherapeutic potential against 15 different human malignancies. These compounds modulate diverse and complex mechanisms, including targeting critical signaling pathways (e.g., PI3K/AKT/mTOR), inducing regulated cell death (e.g., FAS,
Md. Sakhawat Hossain, Sanzida Khatun, Md Mojnu Mia, Fatematuz Zohora, Md. Rifat Sarker, K. M. Tanjida Islam, Md. Abu Sayeed, Moushumi Afroza Mou, Sherif Hamidu, Fatima Hamidu, A. M. Wasaf Hasan, Sanjida Mumtaj, Md Khaled Hossain, Md Sohel   +13 more
wiley   +1 more source

Cell surface interaction of Cdc37 and HSP90.

, 2012
A, Membrane protein fractions from MDA-MB 453 and MDA-MB 231 cells (control) were immunoprecipitaded with anti-Cdc37 antibody. Analysis of bound proteins by Western blot with anti HSP90 antibody and anti HER-2 and anti –EGFR antibodies respectively ...
Evangelia Patsavoudi (140964), Avraam El Hamidieh (140953), Nicholas Grammatikakis (140959)   +2 more
core   +1 more source

Biochemical and Structural Studies of the Interaction of Cdc37 with Hsp90

Journal of Molecular Biology, 2004
The heat shock protein Hsp90 plays a key, but poorly understood role in the folding, assembly and activation of a large number of signal transduction molecules, in particular kinases and steroid hormone receptors. In carrying out these functions Hsp90 hydrolyses ATP as it cycles between ADP- and ATP-bound forms, and this ATPase activity is regulated by
Zhang, W, Hirshberg, M, McLaughlin, S, Lazar, G, Grossmann, J, Nielsen, P, Sobott, F, Robinson, C, Jackson, SE, Laue, E   +9 more
openaire   +2 more sources

Functional Interaction of Human Cdc37 with the Androgen Receptor but Not with the Glucocorticoid Receptor [PDF]

Journal of Biological Chemistry, 2001
Cdc37 is a molecular chaperone closely associated with the folding of protein kinases. Results from studies using a yeast model system showed that it was also important for activation of the human androgen receptor (AR). Based on results from the yeast model system (Fliss, A. E., Fang, Y., Boschelli, F., and Caplan, A. J. (1997) Mol. Biol. Cell 8, 2501-
Rao, Jie, Lee, Paul, Benzeno, Sharon, Cardozo, Chris, Albertus, Julie, Robins, Diane M., Caplan, Avrom J.   +6 more
openaire   +3 more sources

Renoprotective Role and Mechanisms of Luteolin in Chronic Kidney Disease: Insights From NHANES Data, Network Pharmacology, Mendelian Randomization, and Molecular Docking Techniques

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study identified luteolin as a key flavonoid linked to lower CKD risk. Mediation analysis indicated that lower systemic inflammation, reduced serum uric acid, and higher bicarbonate and albumin levels collectively account for part of this relationship.
Mengjin Li, Kai Hu, Juan Chen, Xinming Li, Cheng Xue, Zhiguo Mao   +5 more
wiley   +1 more source

Abstract 2672: Characterization of Hsp90/Cdc37 interaction and their critical residues using luciferase fragment complementation imaging

, 2010
The purpose of this study is to investigate Hsp90/Cdc37 interaction and identify residues critical for the interaction using real-time luciferase complementation imaging and computational modeling.
Yanke Yu, Yanyan LI, Shaomeng Wang, Tao Zhang, Duxin Sun, Yiqun Jiang, Denzil Bernard, Xueqi Fu   +7 more
core   +1 more source