Results 71 to 80 of about 3,509 (196)

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

Molecular Cancer, 2011
Background Multiple myeloma (MM) is a B-cell malignancy that is largely incurable and is characterized by the accumulation of malignant plasma cells in the bone marrow.
Xu Yuan-Ji, Du Zhi-Yan, Zhang Xu-Hui, Zhu Hai-Yan, Ma Jian, Zhao Ming, Yu Xiao-Dan   +6 more
doaj   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Biochemical and Structural Studies of the Interaction of Cdc37 with Hsp90

Journal of Molecular Biology, 2004
The heat shock protein Hsp90 plays a key, but poorly understood role in the folding, assembly and activation of a large number of signal transduction molecules, in particular kinases and steroid hormone receptors. In carrying out these functions Hsp90 hydrolyses ATP as it cycles between ADP- and ATP-bound forms, and this ATPase activity is regulated by
Zhang, W, Hirshberg, M, McLaughlin, S, Lazar, G, Grossmann, J, Nielsen, P, Sobott, F, Robinson, C, Jackson, SE, Laue, E   +9 more
openaire   +2 more sources

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, Volume 5, Issue 11, November 2025.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

Functional Interaction of Human Cdc37 with the Androgen Receptor but Not with the Glucocorticoid Receptor [PDF]

Journal of Biological Chemistry, 2001
Cdc37 is a molecular chaperone closely associated with the folding of protein kinases. Results from studies using a yeast model system showed that it was also important for activation of the human androgen receptor (AR). Based on results from the yeast model system (Fliss, A. E., Fang, Y., Boschelli, F., and Caplan, A. J. (1997) Mol. Biol. Cell 8, 2501-
Rao, Jie, Lee, Paul, Benzeno, Sharon, Cardozo, Chris, Albertus, Julie, Robins, Diane M., Caplan, Avrom J.   +6 more
openaire   +3 more sources

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, Volume 292, Issue 22, Page 5899-5920, November 2025.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

Abstract 2672: Characterization of Hsp90/Cdc37 interaction and their critical residues using luciferase fragment complementation imaging

, 2010
The purpose of this study is to investigate Hsp90/Cdc37 interaction and identify residues critical for the interaction using real-time luciferase complementation imaging and computational modeling.
Yanke Yu, Yanyan LI, Shaomeng Wang, Tao Zhang, Duxin Sun, Yiqun Jiang, Denzil Bernard, Xueqi Fu   +7 more
core   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, Volume 45, Issue 5, Page 1452-1465, September 2025.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Cell surface interaction of Cdc37 and HSP90.

, 2012
A, Membrane protein fractions from MDA-MB 453 and MDA-MB 231 cells (control) were immunoprecipitaded with anti-Cdc37 antibody. Analysis of bound proteins by Western blot with anti HSP90 antibody and anti HER-2 and anti –EGFR antibodies respectively ...
Evangelia Patsavoudi (140964), Avraam El Hamidieh (140953), Nicholas Grammatikakis (140959)   +2 more
core   +1 more source

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

Nature Communications, 2018
The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by ...
Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis   +10 more
doaj   +1 more source