Results 71 to 80 of about 6,074 (204)

Systematic Analysis Reveals Elongation Factor 2 and α-Enolase as Novel Interaction Partners of AKT2. [PDF]

PLoS ONE, 2013
AKT2 is one of the three isoforms of the protein kinase AKT being involved in the modulation of cellular metabolism. Since protein-protein interactions are one possibility to convey specificity in signal transduction, we performed AKT2-protein ...
Katharina Bottermann, Michael Reinartz, Marian Barsoum, Sebastian Kötter, Axel Gödecke   +4 more
doaj   +1 more source

Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. [PDF]

, 2015
Thermal exposure is a serious and growing challenge facing fish species worldwide. Chinook salmon (Oncorhynchus tshawytscha) living in the southern portion of their native range are particularly likely to encounter warmer water due to a confluence of ...
Baerwald, Melinda R, Fangue, Nann A, May, Bernie P, Meek, Mariah H, Rincón, Gonzalo, Stephens, Molly R, Tomalty, Katharine MH   +6 more
core  

A novel mutation in STK11 gene is associated with Peutz-Jeghers Syndrome in Chinese patients [PDF]

, 2011
Background Peutz-Jeghers syndrome (PJS) is caused by mutations in the tumor suppressor gene, STK11, and is characterized by gastrointestinal hamartomas, melanin spots on the lips, and an increased risk of developing cancer.
Zhiqing Wang, Yulan Chen, Baoping Wu, Haoxuan Zheng, Jiman He, Bo Jiang   +5 more
core   +1 more source

How Hsp90 and Cdc37 Lubricate Kinase Molecular Switches [PDF]

Trends in Biochemical Sciences, 2017
The Hsp90/Cdc37 chaperone system interacts with and supports 60% of the human kinome. Not only are Hsp90 and Cdc37 generally required for initial folding, but many kinases rely on the Hsp90/Cdc37 throughout their lifetimes. A large fraction of these 'client' kinases are key oncoproteins, and their interactions with the Hsp90/Cdc37 machinery are crucial
Verba, Kliment A, Agard, David A
openaire   +4 more sources

Renoprotective Role and Mechanisms of Luteolin in Chronic Kidney Disease: Insights From NHANES Data, Network Pharmacology, Mendelian Randomization, and Molecular Docking Techniques

Food Science &Nutrition, Volume 13, Issue 12, December 2025.
This study identified luteolin as a key flavonoid linked to lower CKD risk. Mediation analysis indicated that lower systemic inflammation, reduced serum uric acid, and higher bicarbonate and albumin levels collectively account for part of this relationship.
Mengjin Li, Kai Hu, Juan Chen, Xinming Li, Cheng Xue, Zhiguo Mao   +5 more
wiley   +1 more source

Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells

Exploration of Medicine
Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome.
Jayasree Santhanakrishnan, Prabhu Meganathan, Hemamalini Vedagiri   +2 more
doaj   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, Volume 58, Issue 12, December 2025.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

AUY922 induces retinal toxicity through attenuating TRPM1

Journal of Biomedical Science, 2021
Background Ocular adverse events are common dose-limiting toxicities in cancer patients treated with HSP90 inhibitors, such as AUY922; however, the pathology and molecular mechanisms that mediate AUY922-induced retinal toxicity remain undescribed ...
Che-Hung Shen, Chi-Che Hsieh, Kuan-Ying Jiang, Chih-Yu Lin, Nai-Jung Chiang, Ting-Wei Li, Chun-Ting Yen, Wan-Ju Chen, Daw-Yang Hwang, Li-Tzong Chen   +9 more
doaj   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Mechanisms of Hsp90 regulation [PDF]

, 2016
Heat shock protein 90 (Hsp90) is a molecular chaperone that is involved in the activation of disparate client proteins. This implicates Hsp90 in diverse biological processes that require a variety of co-ordinated regulatory mechanisms to control its ...
Ahn, Akira, Ali, Ali, Amin, Ammirante, Anckar, Anckar, Azevedo, Bali, Bandhakavi, Bansal, Bansal, Bansal, Barlev, Bharadwaj, Blank, Boellmann, Bonizzi, Bonner, Broemer, Brown, Bruce, Budzynski, Bulman, Catlett, Chen, Chen, Chen, Chen, Cho, Chrisostomos Prodromou, Combates, Cotto, Csermely, Cunningham, da Silva Correia, Deb, Dunn, Echeverria, Ehret, Espinosa, Farkas, Field, Finka, Frey, Geiss-Friedlander, Gerondakis, Ghosh, Gomez, Grad, Graf, Gugasyan, Gupta, Hashikawa, Hashikawa, Heimberger, Hensold, Hessling, Hickey, Hietakangas, Holmberg, Holmberg, Holt, Horejsi, Hubert, Ito, Jakob, Johnson, Jurivich, Kadota, Kekatpure, Kettenbach, Kitagawa, Kline, Knauf, Kobayashi, Kugel, Legagneux, Lei, Leskovar, Li, Li, Lindquist, Lingelbach, Liu, Liu, Longshaw, Lu, Makhnevych, Martinez-Ruiz, Mayor, McConnell, McLaughlin, Meyer, Meyer, Meyer, Mitsiades, Miyata, Miyata, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Mollapour, Morimoto, Muller, Murphy, Murtagh, Napetschnig, Neef, Newton, Nieto-Sotelo, Oeckinghaus, Ogiso, Onuoha, Panaretou, Park, Pattaramanon, Pearl, Pearl, Pelham, Peteranderl, Picard, Pirkkala, Pittet, Pratt, Pratt, Prodromou, Prodromou, Prodromou, Prodromou, Prodromou, Qing, Quanz, Rabindran, Rebbe, Retzlaff, Retzlaff, Richter, Roe, Rutherford, Sakurai, Sbroggio, Scheufler, Schuler, Scroggins, Shamovsky, Shao, Shen, Shi, Shiau, Shirasu, Siligardi, Siligardi, Smale, Smith, Solier, Sorger, Sorger, Sorger, Southworth, Steensgaard, Stephanou, Stephanou, Taipale, Takahashi, Takai, Vaughan, Vaughan, Verghese, Voellmy, Voss, Vujanac, Wandinger, Wang, Weikl, Westerheide, Whitesell, Wiederrecht, Williams, Xiao, Xu, Xu, Yahara, Yamamoto, Yang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhao, Zhong, Zhou, Zou, Zuehlke, Zuo, Zuo   +199 more
core   +1 more source