Results 91 to 100 of about 6,074 (204)

Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90

Molecular Cancer, 2011
Background Multiple myeloma (MM) is a B-cell malignancy that is largely incurable and is characterized by the accumulation of malignant plasma cells in the bone marrow.
Xu Yuan-Ji, Du Zhi-Yan, Zhang Xu-Hui, Zhu Hai-Yan, Ma Jian, Zhao Ming, Yu Xiao-Dan   +6 more
doaj   +1 more source

Biochemical and Structural Studies of the Interaction of Cdc37 with Hsp90

Journal of Molecular Biology, 2004
The heat shock protein Hsp90 plays a key, but poorly understood role in the folding, assembly and activation of a large number of signal transduction molecules, in particular kinases and steroid hormone receptors. In carrying out these functions Hsp90 hydrolyses ATP as it cycles between ADP- and ATP-bound forms, and this ATPase activity is regulated by
Zhang, W, Hirshberg, M, McLaughlin, S, Lazar, G, Grossmann, J, Nielsen, P, Sobott, F, Robinson, C, Jackson, SE, Laue, E   +9 more
openaire   +2 more sources

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges

Cancer Science, Volume 116, Issue 7, Page 1795-1806, July 2025.
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li, Bing Wang, Lisha Ye, Guohua Wang   +3 more
wiley   +1 more source

Functional Interaction of Human Cdc37 with the Androgen Receptor but Not with the Glucocorticoid Receptor [PDF]

Journal of Biological Chemistry, 2001
Cdc37 is a molecular chaperone closely associated with the folding of protein kinases. Results from studies using a yeast model system showed that it was also important for activation of the human androgen receptor (AR). Based on results from the yeast model system (Fliss, A. E., Fang, Y., Boschelli, F., and Caplan, A. J. (1997) Mol. Biol. Cell 8, 2501-
Rao, Jie, Lee, Paul, Benzeno, Sharon, Cardozo, Chris, Albertus, Julie, Robins, Diane M., Caplan, Avrom J.   +6 more
openaire   +3 more sources

Regulation of physiological and pathological condensates by molecular chaperones

The FEBS Journal, Volume 292, Issue 13, Page 3271-3297, July 2025.
Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree, Valentina Secco, Flonia Levy‐Adam, Amal Younis, Serena Carra, Reut Shalgi   +5 more
wiley   +1 more source

Integrative cross‐tissue analysis unveils complement‐immunoglobulin augmentation and dysbiosis‐related fatty acid metabolic remodeling during mammalian aging

iMeta, Volume 4, Issue 3, June 2025.
Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang, Rong Li, Yasong Liu, Jinliang Liang, Yihang Gong, Cuicui Xiao, Jianye Cai, Tingting Wang, Qiang You, Jiebin Zhang, Haitian Chen, Jiaqi Xiao, Yingcai Zhang, Yang Yang, Hua Li, Jia Yao, Qi Zhang, Jun Zheng   +17 more
wiley   +1 more source

Comparative genomics reveals common diversity and adaptation to harsh environments in the Arabian Peninsula indigenous chickens

Animal Genetics, Volume 56, Issue 3, June 2025.
Abstract Identifying genomic regions under selection is crucial for comprehending the evolutionary history of the domestic chicken. Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock for production purposes.
Abdulwahad Assiri, Adriana Vallejo‐Trujillo, Mohammed Al‐Abri, Hussain Bahbahani, Faisal Almathen, Abulgasim Ahbara, Waleed Al Marzooqi, Abdulfatai Tijjani, Raman Lawal, Olivier Hanotte   +9 more
wiley   +1 more source

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

Nature Communications, 2018
The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by ...
Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis   +10 more
doaj   +1 more source

Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway [PDF]

, 2017
We found that the heat shock protein 90 (Hsp90) chaperone system of the yeast Saccharomyces cerevisiae is greatly impaired in naa10Δ cells, which lack the NatA N^α-terminal acetylase (Nt-acetylase) and therefore cannot N-terminally acetylate a majority ...
Hyun, Ju-Yeon, Oh, Jang-Hyun, Varshavsky, Alexander   +2 more
core   +2 more sources

The FBXW7‐RPAP2 Axis Controls the Growth of Hepatocellular Carcinoma Cells and Determines the Fate of Liver Cell Differentiation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
The study shows that RPAP2, acting as an oncoprotein, promotes hepatocellular carcinoma (HCC) progression, with its stability being negatively regulated by FBXW7, yet positively by HSP90 and USP7. The FBXW7‐RPAP2 axis plays a crucial role in controlling HCC cell growth and influencing liver cell differentiation.
Danrui Cui, Shengpeng Shao, Ruirui Qu, Xiaoyu Chen, Shanghong Jiang, Linchen Wang, Longyuan Gong, Tianqi Li, Danyi Zhai, Wenfeng Song, Penghong Song, Yi Sun, Tingbo Liang, Xiufang Xiong, Yongchao Zhao   +14 more
wiley   +1 more source