Results 91 to 100 of about 3,509 (196)
ERK5 and cell proliferation: nuclear localization is what matters
Frontiers in Cell and Developmental Biology, 2016 ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell ...
Nestor Gomez +2 more
doaj +1 more source
A role for Cdc37 in EGFRvIII biogenesis
, 2007 The mutant epidermal growth factor receptor, EGFRvIII, is associated with tumour aggressiveness and drug resistance in glioblastoma. Our lab has shown that the molecular chaperone Hsp90 interacts with nascent EGFRvIII, and that EGFRvIII expression and ...
Scales, Stephen
core
陆军军医大学学报Objective To observe the expression profile of epidermal growth factor receptor (EGFR) during the differentiation of osteoclasts, and to explore EGFR-related signaling pathways and key genes during the process.
TAN Xin, ZHANG Ziyuan, LIU Xing
doaj +1 more source
iScienceSummary: Bombinin-BO1 (BO1), a bombinin peptide derived from the skin secretion of Bombina orientalis, exhibits broad-spectrum antimicrobial activity. To date, the anticancer effect of BO1 remains unclear.
Xiaoting Wang +10 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2019 Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence.
Wei Lei +6 more
doaj +1 more source
CDC37 is required for p60v-src activity in yeast.
Molecular Biology of the Cell, 1996 Mutations in genes encoding the molecular chaperones Hsp90 and Ydj1p suppress the toxicity of the protein tyrosine kinase p60v-src in yeast by reducing its levels or its kinase activity. We describe isolation and characterization of novel p60v-src-resistant, temperature-sensitive cdc37 mutants, cdc37-34 and cdc37-17, which produce less p60v-src than ...
B, Dey, J J, Lightbody, F, Boschelli
openaire +3 more sources
Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ [PDF]
, 2015 The protein kinase family includes attractive targets for drug development. Methods for screening of kinase inhibitors remain largely limited to in vitro catalytic assays.
Okuno, Yukiko +7 more
core +1 more source
Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation
, 2022 RAF kinases are RAS-activated enzymes that initiate signaling through the MAPK cascade to control cellular proliferation, differentiation, and survival.
Laura de la Puente Ovejero +27 more
core +1 more source
The Distribution of the Interfacial Hubs in the Hsp90-Cdc37 Complex.
, 2014 (A) The degree of the interfacial hubs in the Hsp90-Cdc37 complex. The highly connected interfacial hubs with the number of connected residues exceeding the default threshold of four are shown for both complexes in filled blue bars.
Kristin Blacklock (447270) +1 more
core +1 more source
, 2007 The IkappaB kinase (IKK) holocomplex, containing the kinases IKKalpha, IKKbeta and the scaffold NEMO (NF-kappaB essential modifier), mediates activation of NF-kappaB by numerous physiological stimuli.
Hinz, M. +6 more
core +1 more source