Results 91 to 100 of about 3,736 (194)

ERK5 and cell proliferation: nuclear localization is what matters

Frontiers in Cell and Developmental Biology, 2016
ERK5, the last MAP kinase family member discovered, is activated by the upstream kinase MEK5 in response to growth factors and stress stimulation. MEK5-ERK5 pathway has been associated to different cellular processes, playing a crucial role in cell ...
Nestor Gomez, Tatiana Erazo, Jose M Lizcano   +2 more
doaj   +1 more source

Epidermal growth factor receptor promotes osteoclast differentiation probably through regulating ABCC1 and CDC37

陆军军医大学学报
Objective To observe the expression profile of epidermal growth factor receptor (EGFR) during the differentiation of osteoclasts, and to explore EGFR-related signaling pathways and key genes during the process.
TAN Xin, ZHANG Ziyuan, LIU Xing
doaj   +1 more source

AURKB/CDC37 complex promotes clear cell renal cell carcinoma progression via phosphorylating MYC and constituting an AURKB/E2F1-positive feedforward loop

Cell Death and Disease
As the second most common malignant tumor in the urinary system, renal cell carcinoma (RCC) is imperative to explore its early diagnostic markers and therapeutic targets.
Fang Li, Xiaofei Wang, Jinyuan Zhang, Xintao Jing, Jing Zhou, Qiuyu Jiang, Li Cao, Shuang Cai, Jiyu Miao, Dongdong Tong, John Y-J. Shyy, Chen Huang   +11 more
doaj   +1 more source

Bombinin-BO1 induces hepatocellular carcinoma cell-cycle arrest and apoptosis via the HSP90A-Cdc37-CDK1 axis

iScience
Summary: Bombinin-BO1 (BO1), a bombinin peptide derived from the skin secretion of Bombina orientalis, exhibits broad-spectrum antimicrobial activity. To date, the anticancer effect of BO1 remains unclear.
Xiaoting Wang, Peiyu Tang, Yitong Gong, Hang Yao, Mingpeng Liang, Hongxia Qu, Xiao Han, Qiusheng Zheng, Zhen Shi, Defang Li, Qingling Jiang   +10 more
doaj   +1 more source

The Alpha Isoform of Heat Shock Protein 90 and the Co-chaperones p23 and Cdc37 Promote Opioid Anti-nociception in the Brain

Frontiers in Molecular Neuroscience, 2019
Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence.
Wei Lei, Wei Lei, David I. Duron, Carrie Stine, Sanket Mishra, Brian S. J. Blagg, John M. Streicher   +6 more
doaj   +1 more source

In Silico Druggability Analysis of Cdc37 in Candidiasis

Candida albicans is an opportunistic fungal pathogen that participates in the life-threatening bloodstream infections. Although the virulent nature of the fungus has been well studied, targeting its druggability for therapeutics still requires extensive ...
Tanushree Mondal, Madhurima Roy, Tanima Saha, Amalesh Mondal, Paromita Saha Mondal, Deepanjan Chattopadhyay, Sanjib Das, Sneha Dey   +7 more
core   +1 more source

CDC37 is required for p60v-src activity in yeast.

Molecular Biology of the Cell, 1996
Mutations in genes encoding the molecular chaperones Hsp90 and Ydj1p suppress the toxicity of the protein tyrosine kinase p60v-src in yeast by reducing its levels or its kinase activity. We describe isolation and characterization of novel p60v-src-resistant, temperature-sensitive cdc37 mutants, cdc37-34 and cdc37-17, which produce less p60v-src than ...
B, Dey, J J, Lightbody, F, Boschelli
openaire   +3 more sources

Molecular Mechanism of Protein Kinase Recognition and Sorting by the Hsp90 Kinome-Specific Cochaperone Cdc37 [PDF]

, 2016
Despite the essential functions of Hsp90, little is known about the mechanism that controls substrate entry into its chaperone cycle. We show that the role of Cdc37 cochaperone reaches beyond that of an adaptor protein and find that it participates in ...
Zhang, Ziming, Liu, Wenjun, Marshall, Devon, Landgraf, Ralf, Larsen, Randy W., Larsen, Randy W, Keramisanou, Dimitra, Diviney, Andrea, Gelis, Ioannis, Aboalroub, Adam   +9 more
core   +1 more source

The Distribution of the Interfacial Hubs in the Hsp90-Cdc37 Complex.

, 2014
(A) The degree of the interfacial hubs in the Hsp90-Cdc37 complex. The highly connected interfacial hubs with the number of connected residues exceeding the default threshold of four are shown for both complexes in filled blue bars.
Kristin Blacklock (447270), Gennady M. Verkhivker (151817)   +1 more
core   +1 more source

Integrated analysis of disulfidptosis-related immune genes signature to boost the efficacy of prognostic prediction in gastric cancer

Cancer Cell International
Background Gastric cancer (GC) remains a malignant tumor with high morbidity and mortality, accounting for approximately 1,080,000 diagnosed cases and 770,000 deaths worldwide annually.
Jie Li, Tian Yu, Juan Sun, Mingwei Ma, Zicheng Zheng, Yixuan He, Weiming Kang, Xin Ye   +7 more
doaj   +1 more source