Results 111 to 120 of about 3,509 (196)

The protein kinase CK2 regulatory subunits regulate function of the Hsp90/Cdc37 protein complex.

, 2012
(A) Hsp90 serine and threonine phosphorylation is severely reduced in the ckb1Δ/ckb1Δ mutant, and Cdc37 serine and threonine phosphorylation is severely reduced in both the ckb1Δ/ckb1Δ and ckb2Δ/ckb2Δ mutants.
Gary D. Bader (14183), Leah E. Cowen (108693), Magali Michaut (76734), Rebecca S. Shapiro (137939), Stephanie Diezmann (57245)   +4 more
core   +1 more source

Candida albicans Cdc37 interacts with the Crk1 kinase and is required for Crk1 production

, 2004
Crk1, a Cdc2-related protein kinase from the human pathogenic fungus Candida albicans, plays an important role in hyphal development and virulence. To address its regulatory mechanisms, we searched for Crk1 interacting proteins by two-hybrid screening. A
Yankun Gao, Gao, Yankun, Liu, Haopin, Chen, Jiangye, Haopin Liu, Jian Ni, Jiangye Chen, Ni, Jian   +7 more
core   +1 more source

Targeting protein-protein interactions in drug discovery: Modulators approved or in clinical trials for cancer treatment

Pharmacological Research
Protein-protein interactions (PPIs) form complex cellular networks fundamental to many key biological processes, including signal transduction, cell proliferation and DNA repair.
Cristina Camps-Fajol, Debora Cavero, Jordi Minguillón, Jordi Surrallés   +3 more
doaj   +1 more source

CDC37 Gene [PDF]

, 2020
openaire   +1 more source

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System [PDF]

Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system.
Prodromou C, Wedge SR, Hallett ST, Blundell KLIM, Wittner A, Felletar I, Noble MEM, Pearl LH, Endicott JA, Morgan RML, Pastok MW   +10 more
core  

The yeast Cdc37 molecular chaperone: its association with Cak1 and its susceptibility to loss with oxidant and molybdate treatment [PDF]

, 2014
In eukaryotic cells the maturation and stabilization of newly-synthesised protein kinase molecules frequently requires the action of Cdc37, a molecular chaperone that will in turn often target these maturing protein kinase molecules onto another ...
Alkuriji, Mohammed
core  

Specific Regulation of Noncanonical p38α Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte

, 2010
Rationale: p38 is an important stress activated protein kinase involved in gene regulation, proliferation, differentiation, and cell death regulation in heart.
Zhang, Jun（Univ Calif Los Angeles）, 韩家淮, Wang, Yibin（Univ Calif Los Angeles）, Han, Jiahuai, Ping, Peipei（Univ Calif Los Angeles）, Ota, Asuka（ Univ Calif Los Angeles）   +5 more
core  

Cdc37 engages in stable, S14A mutation-reinforced association with the most atypical member of the yeast kinome, Cdk-activating kinase (Cak1)

, 2014
In most eukaryotes, Cdc37 is an essential chaperone, transiently associating with newly synthesised protein kinases in order to promote their stabilisation and activation.
Andrew Truman (5282144), Marco Siderius (120652), Mohammed A. Alkuriji (17190664), Stefan Millson (17163565), Peter W. Piper (2379760), Patricija van Oosten-Hawle (14609128)   +5 more
core  

Specific Regulation of Noncanonical p38 alpha Activation by Hsp90-Cdc37 Chaperone Complex in Cardiomyocyte

, 2010
NIH [HL070079, HL062311, HL080111, F31AG032163]Rationale: p38 is an important stress activated protein kinase involved in gene regulation, proliferation, differentiation, and cell death regulation in heart.
Ota, A., 韩家淮, Han, J. H., Wang, Y. B., Ping, P. P., Zhang, J.   +5 more
core  

Targeting the protein-protein interaction between the CDC37 cochaperone and client kinases by an allosteric RAF dimer breaker. [PDF]

J Biol Chem
Yu A, Banerjee S, Malasani S, Towolawi B, Liu Z, Wang Z.   +5 more
europepmc   +1 more source