Results 111 to 120 of about 6,074 (204)
Overexpression of the protein kinase CK2 increases the survival and resistance to chemotherapy of acute myeloid leukemia cells [PDF]
, 2013 Background: The critical role of protein kinase CK2 in the regulation of cellular apoptosis suggests its may be involvement in tumor cell resistance to both conventional and unconventional therapies.
PAVAN, LAURA
core +1 more source
STRAD Pseudokinases Regulate Axogenesis and LKB1 Stability [PDF]
, 2014 BACKGROUND: Neuronal polarization is an essential step of morphogenesis and connectivity in the developing brain. The serine/threonine kinase LKB1 is a key regulator of cell polarity, metabolism, tumorigenesis, and is required for axon formation.
Baas, Annette F. +13 more
core +3 more sources
陆军军医大学学报Objective To observe the expression profile of epidermal growth factor receptor (EGFR) during the differentiation of osteoclasts, and to explore EGFR-related signaling pathways and key genes during the process.
TAN Xin, ZHANG Ziyuan, LIU Xing
doaj +1 more source
CDC37 is required for p60v-src activity in yeast.
Molecular Biology of the Cell, 1996 Mutations in genes encoding the molecular chaperones Hsp90 and Ydj1p suppress the toxicity of the protein tyrosine kinase p60v-src in yeast by reducing its levels or its kinase activity. We describe isolation and characterization of novel p60v-src-resistant, temperature-sensitive cdc37 mutants, cdc37-34 and cdc37-17, which produce less p60v-src than ...
B, Dey, J J, Lightbody, F, Boschelli
openaire +3 more sources
Frontiers in Molecular Neuroscience, 2019 Opioid activation of the mu opioid receptor (MOR) promotes signaling cascades that evoke both analgesic responses to pain and side effects like addiction and dependence.
Wei Lei +6 more
doaj +1 more source
MicroRNA expression patterns in canine mammary cancer show significant differences between metastatic and non-metastatic tumours [PDF]
, 2017 Background MicroRNAs may act as oncogenes or tumour suppressor genes, which make these small molecules potential diagnostic/prognostic factors and targets for anticancer therapies.
Bulkowska, Malgorzata +7 more
core +1 more source
Computational analysis of the LRRK2 interactome. [PDF]
, 2015 LRRK2 was identified in 2004 as the causative protein product of the Parkinson's disease locus designated PARK8. In the decade since then, genetic studies have revealed at least 6 dominant mutations in LRRK2 linked to Parkinson's disease, alongside one ...
Denny, P +3 more
core
Quantitative proteomic study of cell cycle of Prorocentrum donghaiense during the blooming period [PDF]
, 2016 东海原甲藻（Prorocentrumdonghaiense）是中国近海主要有害藻华种，几乎每年都会引发大规模的有害藻华，对海洋生态系统、海洋生物资源和水产养殖造成了严重威胁，并且影响公众健康。尽管目前对东海原甲藻藻华形成的海洋学和生态学机制开展了大量研究，但对现场藻华形成过程中东海原甲藻细胞生长调控的分子机制知之甚少。 本论文以现场东海原甲藻藻华为研究对象，运用基于质谱的定量蛋白质组学技术—iTRAQ（isobarictagsforrelativeandabsolutequantitation）技术 ...
刘九玲
core
Cancer Cell InternationalBackground Gastric cancer (GC) remains a malignant tumor with high morbidity and mortality, accounting for approximately 1,080,000 diagnosed cases and 770,000 deaths worldwide annually.
Jie Li +7 more
doaj +1 more source
PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1
Parkinson's Disease, 2011 Recent publications suggest that the Parkinson's disease- (PD-) related PINK1/Parkin pathway promotes elimination of dysfunctional mitochondria by autophagy.
Aleksandar Rakovic +6 more
doaj +1 more source