Results 81 to 90 of about 3,509 (196)
Exploration, Volume 5, Issue 4, August 2025.Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu +5 more
wiley +1 more source
Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges
Cancer Science, Volume 116, Issue 7, Page 1795-1806, July 2025.Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Gang Li +3 more
wiley +1 more source
SCAND1 suppresses CDC37 gene transcription by repressing MZF1 [PDF]
, 2019 Abstract CDC37 increases the stability of HSP90 client proteins and is essential for numerous intracellular oncogenic signaling pathways. Elevated expression of CDC37 was found in prostate cancer cells, although the regulatory mechanisms through which CDC37 expression becomes increased are unknown.
Eguchi, Takanori +5 more
openaire +1 more source
Conformational Mobility Profiling of the Hsp90-Cdc37 Complex.
, 2014 The NMSF profile of the Hsp90-Cdc37 complex (A) was obtained using the NMR structure (PDB ID 2K5B) of the complex between human Cdc37 (Cdc37-MD, original residue numbering 148–276) and human Hsp90-NTD (original residue numbering 14–223) [25]. The residue-
Kristin Blacklock (447270) +1 more
core +1 more source
Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation
Stem Cell Reports, 2018 Summary: Neural stem cells (NSCs) have the ability to exit quiescence and reactivate in response to physiological stimuli. In the Drosophila brain, insulin receptor (InR)/phosphatidylinositol 3-kinase (PI3K)/Akt pathway triggers NSC reactivation. However,
Jiawen Huang, Hongyan Wang
doaj +1 more source
Regulation of physiological and pathological condensates by molecular chaperones
The FEBS Journal, Volume 292, Issue 13, Page 3271-3297, July 2025.Mounting evidence suggests that stress granules (SGs), dynamic membraneless compartments involved in cellular stress responses, can transition into pathological condensates upon improper disassembly. This review discusses the evidence supporting this notion.
Nadeen Akaree +5 more
wiley +1 more source
iMeta, Volume 4, Issue 3, June 2025.Our study provides a comprehensive multi‐omics profile of aging, integrating proteomic, metabolomic, and metagenomic analyses across diverse tissues and plasma. We identified the synergistic amplification of the circulating complement system and tissue‐wide immunoglobulin accumulation as key molecular drivers of inflammaging.
Feng Zhang +17 more
wiley +1 more source
Genetic interactions among ZDS1,2, CDC37, and protein kinase CK2 in Saccharomyces cerevisiae
, 2003 We report here the identification of the homologous gene pair ZDS1,2 as multicopy suppressors of a temperature-sensitive allele (cka2-13ts) of the CKA2 gene encoding the α′ catalytic subunit of protein kinase CK2.
Glover, Claiborne V.C. +7 more
core +1 more source
Animal Genetics, Volume 56, Issue 3, June 2025.Abstract Identifying genomic regions under selection is crucial for comprehending the evolutionary history of the domestic chicken. Arabian Peninsula (AP) indigenous chickens are mostly found outdoors, being reared alongside other livestock for production purposes.
Abdulwahad Assiri +9 more
wiley +1 more source
, 2008 Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13, but little is known about the regulation of this essential posttranslational modification.
Andrew Truman (5282144) +39 more
core +1 more source