Results 81 to 90 of about 3,736 (194)

Phosphorylation induced cochaperone unfolding promotes kinase recruitment and client class-specific Hsp90 phosphorylation

Nature Communications, 2018
The Hsp90 chaperone cycle is influenced by multiple phosphorylation events but their regulatory functions are poorly understood. Here, the authors show that phosphorylation and unfolding of cochaperone Cdc37 tailors the Hsp90 chaperone cycle by ...
Ashleigh B. Bachman, Dimitra Keramisanou, Wanping Xu, Kristin Beebe, Michael A. Moses, M. V. Vasantha Kumar, Geoffrey Gray, Radwan Ebna Noor, Arjan van der Vaart, Len Neckers, Ioannis Gelis   +10 more
doaj   +1 more source

Tumour Cell Size Control and Its Impact on Tumour Cell Function

Cell Proliferation, Volume 58, Issue 12, December 2025.
The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
wiley   +1 more source

Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang, Hengxiang Zhang, Yuqi Zhou, Chunying Li, Weinan Guo   +4 more
wiley   +1 more source

Hsp83/Hsp90 Physically Associates with Insulin Receptor to Promote Neural Stem Cell Reactivation

Stem Cell Reports, 2018
Summary: Neural stem cells (NSCs) have the ability to exit quiescence and reactivate in response to physiological stimuli. In the Drosophila brain, insulin receptor (InR)/phosphatidylinositol 3-kinase (PI3K)/Akt pathway triggers NSC reactivation. However,
Jiawen Huang, Hongyan Wang
doaj   +1 more source

Bioengineered Extracellular Vesicles in Emerging Cancer Vaccine Platforms

Small Science, Volume 5, Issue 11, November 2025.
This review highlights recent advances in engineering extracellular vesicles (EVs) as next‐generation cancer vaccines. It outlines their biological roles and antigen‐presenting capacity, explores key strategies for antigen loading and delivery optimization, and summarizes preclinical and clinical applications using EVs from diverse immune and tumor ...
Wonkyung Ahn, Yeram Lee, Gi‐Hoon Nam, Jae Bem You, Eun Jung Lee   +4 more
wiley   +1 more source

SCAND1 suppresses CDC37 gene transcription by repressing MZF1 [PDF]

, 2019
Abstract CDC37 increases the stability of HSP90 client proteins and is essential for numerous intracellular oncogenic signaling pathways. Elevated expression of CDC37 was found in prostate cancer cells, although the regulatory mechanisms through which CDC37 expression becomes increased are unknown.
Eguchi, Takanori, Prince, Thomas L., Tran, Manh Tien, Sogawa, Chiharu, Lang, Benjamin J., Calderwood, Stuart K.   +5 more
openaire   +1 more source

Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System [PDF]

Selective recruitment of protein kinases to the Hsp90 system is mediated by the adaptor co-chaperone Cdc37. We show that assembly of CDK4 and CDK6 into protein complexes is differentially regulated by the Cdc37-Hsp90 system.
Prodromou C, Wedge SR, Hallett ST, Blundell KLIM, Wittner A, Felletar I, Noble MEM, Pearl LH, Endicott JA, Morgan RML, Pastok MW   +10 more
core   +4 more sources

Gasdermins: multifunctional effectors of membrane permeabilization across cellular compartments

The FEBS Journal, Volume 292, Issue 22, Page 5899-5920, November 2025.
Gasdermins (GSDMs) are pore‐forming proteins best known for driving pyroptosis through plasma membrane (PM) permeabilization. Beyond triggering inflammatory cell death, GSDMs can also associate with organelle membranes, including mitochondria, lysosomes, ER, and nucleus, where they modulate membrane integrity and cellular signaling.
Eleonora Margheritis, Nadine Gehle, Katia Cosentino   +2 more
wiley   +1 more source

The Hsp90β Isoform: An Attractive Target for Drug Development

Medicinal Research Reviews, Volume 45, Issue 5, Page 1452-1465, September 2025.
ABSTRACT The beta isoform of 90 kDa heat shock protein (Hsp90β) plays a critical role in maintaining cellular proteostasis by assisting in the folding and refolding of proteins, which is essential for both normal cellular function and stress response.
Subhabrata Chaudhury, Terin D'Amico, Brian S. J. Blagg   +2 more
wiley   +1 more source

Hsp90-dependent activation of protein kinases is regulated by chaperone-targeted dephosphorylation of Cdc37

, 2008
Activation of protein kinase clients by the Hsp90 system is mediated by the cochaperone protein Cdc37. Cdc37 requires phosphorylation at Ser13, but little is known about the regulation of this essential posttranslational modification.
Andrew Truman (5282144), Prodromou, Chrisostomos, Clarke, P.A., Hu, Bin, Paul Workman (54973), Workman, P., Truman, Andrew W., Chrisostomos Prodromou (4463035), Panaretou, B., Piper, P.W., Cara K Vaughan (16058129), Smith, J.R., Truman, A.W., Mollapour, Mehdi, Good, Valerie M., Mehdi Mollapour (14913998), Workman, Paul, Pearl, Laurence H., Mollapour, M., Neckers, L., Peter W Piper (16058132), Pearl, L.H., Piper, Peter W., Len Neckers (87881), Valerie M Good (16083335), Prodromou, C., Neckers, Len, Truman, Andrew, Prodrornou, Chrisostolmos, Hu, B., Clarke, Paul A., Smith, Jennifer R., Laurence Pearl (4462603), Jennifer R Smith (16083332), Paul A Clarke (16083338), Good, V.M., Vaughan, Cara K., Panaretou, Barry, Barry Panaretou (3956054), Bin Hu (122268)   +39 more
core   +1 more source