Results 1 to 10 of about 4,383 (155)
Mate and fuse: how yeast cells do it [PDF]
Open Biology, 2013 Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source.
Laura Merlini +2 more
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miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42 [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the role of microRNA-145 (miRNA-145) and microRNA-205 (miRNA-205) in proliferation and invasion of uveal melanoma (UM) cells. METHODS: The expression level of miRNA-145 and miRNA-205 from samples of UM patients were determined by ...
Yang Li +3 more
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Cells, 2020 Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control.
Bo Zhang +4 more
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Zhongguo shuxue zazhi, 2023 Objective To explore critical regulatory genes in the hemoglobin switch process by analyzing transcriptomic data from the GSE6236, GSE17639 and GSE35102 datasets.
Jinchao WANG, Genhao ZHANG
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Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. [PDF]
PLoS ONE, 2011 Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation.
Huzoor Akbar +7 more
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Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
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Cdc42 controls secretory granules morphology in rodent salivary glands in vivo
Communicative & Integrative Biology, 2020 We previously reported that the small GTPase Cdc42 negatively regulates endocytosis in the salivary gland of live mice. By using intravital subcellular microscopy, we showed that depletion of Cdc42 causes the mis-sorting of plasma membrane components ...
Akiko Shitara +2 more
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Cells, 2020 The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously ...
Iker Lamas +2 more
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Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β
Journal of Integrative Neuroscience, 2022 Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li +10 more
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Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
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