Functions of p120ctn isoforms in cell-cell adhesion and intracellular signaling [PDF]
, 2012 The functions of many organs depend on the generation of an epithelium. The transition from a set of loosely connected nonpolarized cells to organized sheets of closely associated polarized epithelial cells requires the assembly of specialized cell ...
Pieters, Tim +2 more
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KIF4A drives gliomas growth by transcriptional repression of Rac1/Cdc42 to induce cytoskeletal remodeling in glioma cells [PDF]
, 2022 Hui Zhang +6 more
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Regulation of Cdc42 for polarized growth in budding yeast
Microbial Cell, 2020 The Rho GTPase Cdc42 is a central regulator of cell polarity in diverse cell types. The activity of Cdc42 is dynamically controlled in time and space to enable distinct polarization events, which generally occur along a single axis in response to spatial
Kristi E. Miller +2 more
doaj +1 more source
CDC42 and Rac1 control different actin-dependent processes in the Drosophila wing disc epithelium. [PDF]
, 1995 Cdc42 and Rac1 are members of the rho family of small guanosinetriphosphatases and are required for a diverse set of cytoskeleton-membrane interactions in different cell types.
Auvinen, P +4 more
core
Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells [PDF]
, 2014 Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity,
Alonso, Daniel Fernando +7 more
core +2 more sources
Diabetes, Metabolic Syndrome and Obesity, 2019 Xing-Hua Xiao,* Qi-Yuan Huang,* Xian-Ling Qian,* Jing Duan, Xue-Qiao Jiao, Long-Yuan Wu, Qing-Yun Huang, Jun Li, Xing-Ning Lai, Yu-Bo Shi, Li-Xia Xiong Department of Pathophysiology, Medical College, Nanchang University, Nanchang 330006, People’s ...
Xiao XH +10 more
doaj
Spontaneous Cdc42 polarization independent of GDI-mediated extraction and actin-based trafficking.
PLoS Biology, 2015 The small Rho-family GTPase Cdc42 is critical for cell polarization and polarizes spontaneously in absence of upstream spatial cues. Spontaneous polarization is thought to require dynamic Cdc42 recycling through Guanine nucleotide Dissociation Inhibitor (
Felipe O Bendezú +5 more
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JCI Insight, 2020 The regulatory mechanisms enabling the intestinal epithelium to maintain a high degree of regenerative capacity during mucosal injury remain unclear. Ex vivo survival and clonogenicity of intestinal stem cells (ISCs) strictly required growth response ...
Xiao Zhang +18 more
doaj +1 more source
Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. [PDF]
, 2014 The exocyst serves to tether secretory vesicles to cortical sites specified by polarity determinants, in preparation for fusion with the plasma membrane.
Liu, Dongmei, Novick, Peter
core +1 more source
Stress-dependent inhibition of cell polarity through unbalancing the GEF/GAP regulation of Cdc42 [PDF]
, 2021 Clàudia Salat-Canela +5 more
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