Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast [PDF]
Cells, 2020 The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously ...
Iker Lamas +2 more
doaj +2 more sources
Targeting Rac and Cdc42 GEFs in Metastatic Cancer
Frontiers in Cell and Developmental Biology, 2020 The Rho family GTPases Rho, Rac, and Cdc42 have emerged as key players in cancer metastasis, due to their essential roles in regulating cell division and actin cytoskeletal rearrangements; and thus, cell growth, migration/invasion, polarity, and adhesion.
Maria del Mar Maldonado +3 more
doaj +2 more sources
Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction [PDF]
bioRxiv, 2018 The formation of a local zone of Cdc42 GTPase activity, which governs cell polarization in many cell types, requires not only local activation but also switch-off mechanisms.
Daniela Gallo Castro, Sophie G. Martin
semanticscholar +2 more sources
KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration. [PDF]
PLoS GeneticsThe small GTPase CDC42 promotes axon growth through actin filament polymerization and this growth is driven by axonal localization of the mRNA encoding the prenylated CDC42 isoform (Prenyl-Cdc42).
Matthew D Zdradzinski +13 more
doaj +2 more sources
Subcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration [PDF]
Molecular Biology of the Cell, 2016 Migratory immune cells use intracellular signaling networks to generate and orient spatially polarized responses to extracellular cues. The monomeric G protein Cdc42 is believed to play an important role in controlling the polarized responses, but it has
Gautam, N. +2 more
core +3 more sources
Regulation of Cdc42 for polarized growth in budding yeast
Microbial Cell, 2020 The Rho GTPase Cdc42 is a central regulator of cell polarity in diverse cell types. The activity of Cdc42 is dynamically controlled in time and space to enable distinct polarization events, which generally occur along a single axis in response to spatial
Kristi E. Miller +2 more
doaj +2 more sources
A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. [PDF]
PLoS ONE, 2018 The conserved Rho-family GTPase Cdc42 is a master regulator of polarity establishment in many cell types. Cdc42 becomes activated and concentrated in a region of the cell cortex, and recruits a variety of effector proteins to that site.
Christine N Daniels +2 more
doaj +2 more sources
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs
Cells, 2019 Breast cancer is the most common malignant tumors in females. Although the conventional treatment has demonstrated a certain effect, some limitations still exist.
Yu Zhang +5 more
doaj +2 more sources
Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis [PDF]
, 2015 © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 26 (2015): 3520-3534, doi:10.1091/mbc.E15-02-0095.Active Cdc42 GTPase ...
Buchwald, Peter +8 more
core +3 more sources
CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis [PDF]
EMBO ReportsCDC42 is a member of Rho GTPase family that regulates various biological processes and its activity can be hijacked by invading pathogens. Here, we discovered that the level of active CDC42 in hepatocytes positively correlates with the entry capacity of ...
Shuzhi Cui +6 more
doaj +2 more sources