Results 111 to 120 of about 81,267 (316)
Negative regulation of CDC42 expression and cell cycle progression by miR-29a in breast cancer
Open Medicine, 2016 The inhibitory role of microRNA-29a (miR-29a) has been assessed in breast cancer cells. Herein, we analyze the underlying mechanisms of its role in cell cycle progression in breast cancer cells.
Zhang Mingliang +3 more
doaj +1 more source
Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. [PDF]
PLoS ONE, 2011 Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific.
Fukun Guo +10 more
doaj +1 more source
Clinical relevance of the transcriptional signature regulated by CDC42 in colorectal cancer [PDF]
, 2017 CDC42 is an oncogenic Rho GTPase overexpressed in colorectal cancer (CRC). Although CDC42 has been shown to regulate gene transcription, the specific molecular mechanisms regulating the oncogenic ability of CDC42 remain unknown.
Bandrés, Eva +9 more
core +3 more sources
Cdc42 and aging of hematopoietic stem cells [PDF]
Current Opinion in Hematology, 2013 Hematopoietic stem cells (HSCs) continuously provide mature blood cells during the lifespan of a mammal. The functional decline in hematopoiesis in the elderly, which involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, is partly linked to HSC aging.
Hartmut Geiger, Yi Zheng
openaire +2 more sources
BioEssays, EarlyView.Cell shape changes underlie animal development, physiology, and disease. The cell surface is mechanosensitive to the microenvironment and cytoskeleton activities, which generate plasma membrane topographies recognized and affected by Arp2/3 actin network induction pathways to remodel cell shape during immune cell migration, neural progenitor cell ...
Tony J. C. Harris
wiley +1 more source
Cloning and differential expression analyses of Cdc42 from sheep
Journal of Veterinary Research, 2018 Serological diagnosis of brucellosis is still a great challenge due to the infeasibility of discriminating infected animals from vaccinated ones, so it is necessary to search for diagnostic biomarkers for differential diagnosis of brucellosis.
Yang Yong-Jie +10 more
doaj +1 more source
miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis
Journal of experimental & clinical cancer research : CR, 2018 BackgroundOur previous work showed that some Rho GTPases, including Rho, Rac1 and Cdc42, play critical roles in gastric cancer (GC); however, how they are regulated in GC remains largely unknown.
Xiaowei Li +13 more
semanticscholar +1 more source
Cytoskeleton, EarlyView.Abstract Tissue tension encompasses the mechanical forces exerted on solid tissues within animal bodies, originating from various sources such as cellular contractility, interactions with neighboring cells and the extracellular matrix. Emerging evidence indicates that an imbalance in such forces can influence structural organization, homeostasis, and ...
Wan J. Gan +7 more
wiley +1 more source
FLIM FRET Visualization of Cdc42 Activation by Netrin-1 in Embryonic Spinal Commissural Neuron Growth Cones. [PDF]
PLoS ONE, 2016 Netrin-1 is an essential extracellular chemoattractant that signals through its receptor DCC to guide commissural axon extension in the embryonic spinal cord.
Benjamin Rappaz +4 more
doaj +1 more source
Frontiers in Endocrinology, 2022 ObjectivesThe progressive impairment of β-cell function results in prolonged deterioration in patients with type 2 diabetes mellitus (T2DM). Interestingly, the finding on pancreatitis secondary to renal injury suggests that potential communication exists
Shan Jiang +15 more
doaj +1 more source