Results 111 to 120 of about 86,770 (308)

Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. [PDF]

PLoS Pathogens, 2012
Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), a human malignancy notorious for its highly metastatic nature. Among EBV-encoded genes, latent membrane protein 1 (LMP1) is expressed in most NPC tissues and exerts ...
Hao-Ping Liu, Chia-Chun Chen, Chih-Ching Wu, Yi-Chuan Huang, Shu-Chen Liu, Ying Liang, Kai-Ping Chang, Yu-Sun Chang   +7 more
doaj   +1 more source

Regulation of plasma membrane expansion during axon formation [PDF]

, 2018
Here, will review current evidence regarding the signaling pathways and mechanisms underlying membrane addition at sites of active growth during axon formation.Fil: Quiroga, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas.
Bisbal, Mariano, Caceres, Alfredo Oscar, Quiroga, Santiago   +2 more
core   +1 more source

miR-148b-3p inhibits gastric cancer metastasis by inhibiting the Dock6/Rac1/Cdc42 axis

Journal of experimental & clinical cancer research : CR, 2018
BackgroundOur previous work showed that some Rho GTPases, including Rho, Rac1 and Cdc42, play critical roles in gastric cancer (GC); however, how they are regulated in GC remains largely unknown.
Xiaowei Li, M. Jiang, Di Chen, Bing Xu, Rui Wang, Y. Chu, Weijie Wang, Lin Zhou, Zhijie Lei, Y. Nie, D. Fan, Y. Shang, Kaichun Wu, Jie Liang   +13 more
semanticscholar   +1 more source

Cdc42 in oncogenic transformation, invasion, and tumorigenesis [PDF]

Cellular Signalling, 2011
The Rho family of GTPases represents a class of Ras-related signaling molecules often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP-bound, active state in response to extracellular stimuli such as mitogens and extracellular matrix.
Kristy, Stengel, Yi, Zheng
openaire   +2 more sources

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. [PDF]

PLoS ONE, 2011
Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific.
Fukun Guo, Shuangmin Zhang, Pulak Tripathi, Jochen Mattner, James Phelan, Alyssa Sproles, Jun Mo, Marsha Wills-Karp, H Leighton Grimes, David Hildeman, Yi Zheng   +10 more
doaj   +1 more source

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization [PDF]

, 2010
The modeling and remodeling of bone requires activation and polarization of osteoclasts, achieved by reorganization of the cytoskeleton. Members of the Rho subfamily of small GTPases, including Cdc42, are known regulators of cytoskeletal components, but ...
Barfod, F. Patrick Ross, Faccio, Gnesutta, Haibo Zhao, Ikeda, James F. Johnson, Jean Chappel, Steven L. Teitelbaum, Vaananen, Wei Zou, Yi Zheng, Yuji Ito, Zhang, Zhou   +14 more
core   +3 more sources

Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion

Molecular Biology of the Cell, 2018
The anisotropic organization of plasma membrane constituents is indicative of mechanisms that drive the membrane away from equilibrium. However, defining these mechanisms is challenging due to the short spatiotemporal scales at which diffusion operates ...
Elodie Sartorel, Caner Ünlü, Mini Jose, A. Massoni-Laporte, Julien Meca, J. Sibarita, Derek McCusker   +6 more
semanticscholar   +1 more source

Single‐Cell Morphomechanics of Prostate Cancer‐Associated Fibroblasts Identifies Distinct Features Associated with Patient Outcome

Advanced Science, EarlyView.
Cancer‐associated fibroblasts (CAFs) in prostate tumors exhibit distinct morphomechanical traits vs normal fibroblasts, including greater stiffness and volume, more elongated stress fibres, and larger and more elongated nuclei. These features, quantified through imaging and real‐time deformability cytometry, correlate with patient outcomes and can be ...
Antje Garside, Angela Jacobi, Shivakumar Keerthikumar, Vaibhav Mahajan, Michelle Richards, Birunthi Niranjan, Linda Teng, Nicholas Choo, Johannes Low Jun Wei, Gail P Risbridger, Mitchell G Lawrence, Anna V. Taubenberger   +11 more
wiley   +1 more source

Merlin Phosphorylation by p21-activated Kinase 2 and Effects of Phosphorylation on Merlin Localization [PDF]

, 2002
The Nf2 tumor suppressor gene product merlin is related to the membrane-cytoskeleton linker proteins of the band 4.1 superfamily, including ezrin, radixin, and moesin (ERMs). Merlin is regulated by phosphorylation in a Rac/cdc42-dependent fashion.
Eckman, Matthew S., Jacks, Tyler, Johnson, Kristen C., Kissil, Joseph L.   +3 more
core   +1 more source