Results 121 to 130 of about 75,568 (261)
Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]
, 2015 The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P. +7 more
core +2 more sources
Cdc42-driven podosome formation in endothelial cells
European Journal of Cell Biology, 2006 Ectopic expression of a constitutive active mutant of the GTPase Cdc42 (V12Cdc42) in vascular endothelial cells triggers the dissolution of stress fibres and focal adhesion contacts and causes the repolymerisation of actin into dots. Each punctate structure consists of an F-actin core surrounded by a vinculin ring, consistent with the definition of ...
Violaine, Moreau +5 more
openaire +2 more sources
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
Cdc42 mobility and membrane flows regulate fission yeast cell shape and survival
Nature CommunicationsPolarized exocytosis induced by local Cdc42 GTPase activity results in membrane flows that deplete low-mobility membrane-associated proteins. A reaction-diffusion particle model comprising Cdc42 positive feedback activation, hydrolysis by GTPase ...
David M. Rutkowski +3 more
doaj +1 more source
Impact of organic pollutants on phenotype and gene expression in human breast cancer cells
Journal of Applied Toxicology, Volume 46, Issue 5, Page 1487-1505, May 2026.ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin +7 more
wiley +1 more source
Cellular and Molecular Life SciencesCell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in cell cycle division, cytoskeleton arrangement, cell polarization, membrane trafficking and signal transduction.
Ke Wen +15 more
doaj +1 more source
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs
Cells, 2019 Breast cancer is the most common malignant tumors in females. Although the conventional treatment has demonstrated a certain effect, some limitations still exist.
Yu Zhang +5 more
doaj +1 more source
Supplementary 4: Optimal conditions for Cdc42 siRNA mediated knockdown.
, 2022 Alyssa Biondo, Patricio Meneses
openalex +1 more source
Cancer Medicine, Volume 15, Issue 4, April 2026.Expression of RHO GTPases in myeloid malignancies. Gene expression analysis of ten RHO GTPases revealed RHOBTB2, RND2, and RHOQ as differently expressed in patients with MDS and/or AML. RHOBTB2 was identified as a promising prognostic indicator. BM, bone marrow. MDS, myelodysplastic neoplasm. AML, acute myeloid leukemia.
Beatriz de Almeida Rodrigues +5 more
wiley +1 more source
Systems Analysis Implicates WAVE2 Complex in the Pathogenesis of Developmental Left-Sided Obstructive Heart Defects. [PDF]
, 2020 Genetic variants are the primary driver of congenital heart disease (CHD) pathogenesis. However, our ability to identify causative variants is limited.
Bernstein, Daniel +25 more
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