A Rho family GTPase controls actin dynamics and tip growth via two counteracting downstream pathways in pollen tubes. [PDF]
, 2005 Tip growth in neuronal cells, plant cells, and fungal hyphae is known to require tip-localized Rho GTPase, calcium, and filamentous actin (F-actin), but how they interact with each other is unclear.
Dowd, Peter +6 more
core +3 more sources
Regulation of neurogenesis by Fgf8a requires Cdc42 signaling and a novel Cdc42 effector protein
Developmental Biology, 2013 Fibroblast growth factor (FGF) signaling is required for numerous aspects of neural development, including neural induction, CNS patterning and neurogenesis. The ability of FGFs to activate Ras/MAPK signaling is thought to be critical for these functions.
Hulstrand, Alissa M. +1 more
openaire +2 more sources
Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD
Developmental Dynamics, EarlyView.Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim +4 more
wiley +1 more source
Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall
eLife, 2014 Cdc42 is a signaling protein important for reorganization of actin cytoskeleton and morphogenesis of cells. However, the functional role of Cdc42 in synaptic plasticity and in behaviors such as learning and memory are not well understood.
Il Hwan Kim +3 more
doaj +1 more source
Deciphering interplay between Salmonella invasion effectors [PDF]
, 2007 Bacterial pathogens have evolved a specialized type III secretion system (T3SS) to translocate virulence effector proteins directly into eukaryotic target cells.
AL Rozelle +45 more
core +5 more sources
The role of Rho GTPases in facial morphogenesis
Developmental Dynamics, EarlyView.The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley +1 more source
Opposing Expressions of Nidogen-1 and Cdc42 Genes in the Development of Liver Cirrhosis in Patients with Non-Alcoholic Fatty Liver Disease [PDF]
پزشکی بالینی ابن سیناBackground and Objective: The roles of Nidogen-1 and Cdc42 genes as significant factors in the metabolism of the extracellular matrix have been demonstrated in the fibrosis of various tissues. This study investigates the gene expressions of Nidogen-1 and
Zahra Ali +2 more
doaj
Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]
, 2012 The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
core +3 more sources
Journal of Biological Chemistry, 2018 IQ motif–containing GTPase-activating proteins (IQGAPs) are scaffolding proteins playing central roles in cell–cell adhesion, polarity, and motility. The Rho GTPases Cdc42 and Rac1, in their GTP-bound active forms, interact with all three human IQGAPs ...
E. Ozdemir +7 more
semanticscholar +1 more source
Stress-dependent inhibition of cell polarity through unbalancing the GEF/GAP regulation of Cdc42 [PDF]
, 2021 Clàudia Salat-Canela +5 more
openalex +1 more source