Results 171 to 180 of about 86,770 (308)

Design, Synthesis, In Vitro and In Vivo Characterization of CDC42 GTPase Interaction Inhibitors for the Treatment of Cancer

, 2023
Nicoletta Brindani, Linh M. Vuong, Isabella Maria Acquistapace, Maria Antonietta La Serra, José Antonio Ortega, Marina Veronesi, Sine Mandrup Bertozzi, Maria Summa, Stefania Girotto, Rosalia Bertorelli, Andrea Armirotti, Anand K. Ganesan, Marco De Vivo   +12 more
openalex   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Serum CDC42 level change during abiraterone plus prednisone treatment and its association with prognosis in metastatic castration-resistant prostate cancer patients

Discover Oncology
Objective Cell division cycle 42 (CDC42) regulates prostate cancer growth and metastasis. This study aimed to evaluate the change in serum CDC42 during treatment and its association with the clinical features and prognosis in abiraterone plus prednisone ...
Yong Ma, Zhihua Cao, Jiacheng Zhang, Xu Zhu, Zhonghao Zhao, Jinguo Xiong   +5 more
doaj   +1 more source

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Aging Cell, Volume 25, Issue 2, February 2026.
Hematopoietic aging arises from intrinsic stem‐cell decline and bone‐marrow niche dysfunction, leading to myeloid skewing, immunosenescence, and clonal hematopoiesis. These changes drive systemic inflammation and multi‐organ disease, which in turn further disrupt the bone‐marrow niche and hematopoietic stem cell (HSC) function, creating a vicious cycle
Masashi Miyawaki, Seiji Hashimoto, Sumito Ogawa, Yoshitaka Kase   +3 more
wiley   +1 more source

Mechanopharmacology of cellular microenvironment stiffness: Therapeutic strategies for age‐related diseases

British Journal of Pharmacology, Volume 183, Issue 4, Page 945-956, February 2026.
Ageing brings about various biochemical, structural and mechanical alterations within tissues, profoundly impacting cellular behaviour and function. One of the hallmark changes observed with ageing is an increase in cellular microenvironment stiffness, a biomechanical property influenced by intrinsic factors within the cell and extrinsic factors from ...
Wang HaiYang, Cheong Dorothy Hui Juan, Lee Zhao‐Yong, Tran Thai   +3 more
wiley   +1 more source

Une nouvelle protéine RhoGAP impliquée dans la régulation du complexe Arp2/3 au niveau de l’appareil de Golgi : Un relais entre les protéines G ARF1 et Cdc42 [PDF]

, 2005
Thierry Dubois, Philippe Chavrier
openalex   +1 more source

Microtubule Inhibitors Induce Cross‐Resistance to Osimertinib Through CaMKII Activation in EGFR‐Mutated NSCLC

Cancer Science, Volume 117, Issue 2, Page 418-428, February 2026.
Eighteen‐week treatment with microtubule inhibitors induces resistance to osimertinib in EGFR‐mutated NSCLC cells. Vinorelbine‐ and paclitaxel‐resistant cells showed activation of FZD7 and CaMKII and increased sensitivity to CaMKII inhibition, with additive or synergistic effects when combined with osimertinib.
Kento Kono, Ryosuke Tanino, Yukari Tsubata, Eshat Fahmida Haque, Takeshi Isobe, Tamio Okimoto   +5 more
wiley   +1 more source

Antagonistic Cross-talk between Rac and Cdc42 GTPases Regulates Generation of Reactive Oxygen Species [PDF]

, 2004
Becky A. Diebold, Bruce Fowler, Justine Lu, Mary C. Dinauer, Gary Bokoch   +4 more
openalex   +1 more source

miR-29a Negatively Affects Glucose-Stimulated Insulin Secretion and MIN6 Cell Proliferation via Cdc42/β-Catenin Signaling

International Journal of Endocrinology, 2019
Background. Diabetes is a progressive metabolic disease characterized by hyperglycemia. Functional impairment of islet β cells can occur to varying degrees.
Jing Duan, Xian-Ling Qian, Jun Li, Xing-Hua Xiao, Xiang-Tong Lu, Lin-Chen Lv, Qing-Yun Huang, Wen Ding, Hong-Yan Zhang, Li-Xia Xiong   +9 more
doaj   +1 more source

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

Cell, 1995
C. Nobes, A. Hall
semanticscholar   +1 more source