Results 171 to 180 of about 81,267 (316)

Phenotypic Expansion of Knobloch Syndrome Type 2 in an Individual With a De Novo PAK2 Variant

American Journal of Medical Genetics Part A, Volume 197, Issue 6, June 2025.
ABSTRACT P21‐activated kinase 2 (PAK2) is a serine/threonine kinase essential for a variety of cellular processes including signal transduction, cellular survival, proliferation, and migration. A recent report proposed monoallelic PAK2 variants cause Knobloch syndrome type 2 (KNO2)—a developmental disorder primarily characterized by ocular anomalies ...
Elizabeth A. Werren, Louisa Kalsner, Jessica M. Ewald, Michael Peracchio, Cameron King, Purva Vats, Peter A. Audano, Peter N. Robinson, Mark D. Adams, Melissa A. Kelly, Adam P. Matson   +10 more
wiley   +1 more source

A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.

PLoS ONE, 2018
The conserved Rho-family GTPase Cdc42 is a master regulator of polarity establishment in many cell types. Cdc42 becomes activated and concentrated in a region of the cell cortex, and recruits a variety of effector proteins to that site.
Christine N Daniels, Trevin R Zyla, Daniel J Lew   +2 more
doaj   +1 more source

Endometriosis risk alleles at 1p36.12 act through inverse regulation of CDC42 and LINC00339.

Human Molecular Genetics, 2016
Genome-wide association studies (GWAS) have identified markers within the WNT4 region on chromosome 1p36.12 showing consistent and strong association with increasing endometriosis risk.
J. Powell, J. Fung, K. Shakhbazov, Y. Sapkota, N. Cloonan, G. Hemani, Kristine M Hillman, Susanne Kaufmann, H. Luong, L. Bowdler, J. Painter, S. Holdsworth-Carson, P. Visscher, M. Dinger, M. Healey, D. Nyholt, J. French, S. Edwards, P. Rogers, G. Montgomery   +19 more
semanticscholar   +1 more source

Plac1+ Tumor Cell‐Treg Interplay Supports Tumorigenesis and Progression of Head and Neck Cancer

Advanced Science, Volume 12, Issue 17, May 8, 2025.
Meng et al. screen genes in the CTAs family and find Plac1 is specifically expressed in head and neck squamous cell carcinoma (HNSCC) cells. They reveal that Plac1 expression promotes HNSCC progression directly by activating PI3K/AKT signaling pathway.
Xiaoyan Meng, Zhonglong Liu, Lu Zhao, Ran Li, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +8 more
wiley   +1 more source

CDC42 and CDC43, two additional genes involved in budding and the establishment of cell polarity in the yeast Saccharomyces cerevisiae. [PDF]

, 1990
A.E. Adams, Douglas I. Johnson, Richard Longnecker, Barbara Furin Sloat, John R. Pringle   +4 more
openalex   +1 more source

Identification of the Micro‐Ribonucleic Acid Profiles of Plant‐Derived Extracellular Vesicles and their Potential Crosskingdom Regulation

Advanced NanoBiomed Research, Volume 5, Issue 5, May 2025.
The present study employs small RNA sequencing to identify the types and content of microRNAs (miRNAs) in four widely utilized plant‐derived extracellular vesicles (pEVs). The functional annotation reveals that the pEV miRNAs are involved in regulating the progression of human cancer and viral infection, thereby demonstrating the crosskingdom ...
Fei Wang, Junyao Deng, Shushan Mo, Jiacong Ai, Yingxian Xiao, Xiaohan Zhou, Zhenhua Li, Lanya Li   +7 more
wiley   +1 more source

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation.

Blood, 2017
As a central regulator of cell polarity, the activity of CDC42 GTPase is tightly controlled in maintaining normal hematopoietic stem and progenitor cell (HSC/P) functions.
B. Mizukawa, Eric O'Brien, Daniel C. Moreira, M. Wunderlich, Cindy L. Hochstetler, X. Duan, Wei Liu, Emily Orr, H. Grimes, J. Mulloy, Yi Zheng   +10 more
semanticscholar   +1 more source

Expression and Purification of Cdc42 and PBD46

The FASEB Journal, 2012
The Ras superfamily consists of low molecular weight G‐proteins that are heavily involved in cellular signaling, leading to various downstream responses. Like other Ras proteins, Cdc42 acts as a molecular switch interchanging from its active (GTP‐bound) and inactive (GDP‐bound) state through the utilization of GAP (GTPase‐activating proteins) and GEF ...
Edward J Evans, Paul D. Adams
openaire   +1 more source

F‐actin in the cuticular plate and junctions of auditory hair cells is regulated by ADF and cofilin to allow for normal stereocilia bundle patterning and maintenance

Cytoskeleton, Volume 82, Issue 5, Page 302-310, May 2025.
Abstract Auditory hair cells, which convert sound‐induced vibrations in the inner ear into neural signals, depend on multiple actin populations for normal function. Stereocilia are mechanosensory protrusions formed around a core of linear, crosslinked F‐actin.
Jamis McGrath, Katelin Hawbaker, Benjamin J. Perrin   +2 more
wiley   +1 more source

Molecular Cloning and Expression of a G25K cDNA, the Human Homolog of the Yeast Cell Cycle Gene CDC42 [PDF]

, 1990
S Munemitsu, Michael A. Innis, Robin Clark, Frank McCormick, Axel Ullrich, Paul Polakis   +5 more
openalex   +1 more source