Results 181 to 190 of about 38,210 (217)
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Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
Nature Chemical Biology, 2005Inspired by the usefulness of small molecules to study membrane traffic, we used high-throughput synthesis and phenotypic screening to discover secramine, a molecule that inhibits membrane traffic out of the Golgi apparatus by an unknown mechanism. We report here that secramine inhibits activation of the Rho GTPase Cdc42, a protein involved in membrane
Henry E, Pelish +9 more
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Regulation of anoikis by Cdc42 and Rac1
Experimental Cell Research, 2004Ras family small GTPases play a critical role in malignant transformation, and Rho subfamily members contribute significantly to this process. Anchorage-independent growth and the ability to avoid detachment-induced apoptosis (anoikis) are hallmarks of transformed epithelial cells.
Tzu-Ling, Cheng +2 more
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1999
Rac and Cdc42, like all members of the Ras superfamily, act as molecular switches, cycling between an inactive GDP-bound state and an active GTPbound state. Until recently, members of the Rho-subfamily were believed to be primarily involved in the regulation of cytoskeletal organization in response to extracellular growth factors. However, studies from
B, Boettner, L, Van Aelst
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Rac and Cdc42, like all members of the Ras superfamily, act as molecular switches, cycling between an inactive GDP-bound state and an active GTPbound state. Until recently, members of the Rho-subfamily were believed to be primarily involved in the regulation of cytoskeletal organization in response to extracellular growth factors. However, studies from
B, Boettner, L, Van Aelst
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Biochemistry, 1999
Most of the putative effectors for the Rho-family small GTPases Cdc42 and Rac share a common sequence motif referred to as the Cdc42/Rac interactive binding (CRIB) motif. This sequence, with a consensus of I-S-x-P-(x)2-4-F-x-H-x-x-H-V-G [Burbelo, P. D., et al. (1995) J. Biol. Chem.
Stevens, W K +5 more
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Most of the putative effectors for the Rho-family small GTPases Cdc42 and Rac share a common sequence motif referred to as the Cdc42/Rac interactive binding (CRIB) motif. This sequence, with a consensus of I-S-x-P-(x)2-4-F-x-H-x-x-H-V-G [Burbelo, P. D., et al. (1995) J. Biol. Chem.
Stevens, W K +5 more
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Analysis of a Mitotic Role of Cdc42
2006Rho GTPases including Rho, Rac, and Cdc42 determine the cell shape by regulating the actin and microtubule dynamics. Through these actions on cytoskeleton, Rho GTPases also regulate cell cycle progression. Specifically, Rho, Rac, and Cdc42 regulate G1-S progression, and Rho regulates cytokinesis.
Shingo, Yasuda, Shuh, Narumiya
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Cdc42: An important regulator of neuronal morphology
The International Journal of Biochemistry & Cell Biology, 2012Regulation of neuronal morphology and activity-dependent synaptic modifications involves reorganization of the actin cytoskeleton. Dynamic changes of the actin cytoskeleton in many cell types are controlled by small GTPases of the Rho family, such as RhoA, Rac1 and Cdc42.
Chen, Chen +2 more
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Trends in Cell Biology, 2004
The roles of Cdc42 in stimulating changes in the actin cytoskeleton and in the establishment of cell polarity have been known for some time. However, evidence implicating Cdc42 in intracellular trafficking and in the regulation of cell growth have continued to surface.
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The roles of Cdc42 in stimulating changes in the actin cytoskeleton and in the establishment of cell polarity have been known for some time. However, evidence implicating Cdc42 in intracellular trafficking and in the regulation of cell growth have continued to surface.
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Expressions of Rac1, Tiam1 and Cdc42 in retinoblastoma
Experimental Eye Research, 2006The Rho GTPases are the molecular regulators of the cell motility processes and are involved in cell cycle progression and gene transcription. We studied the expression of Rho-like GTPases molecules, particularly Rac, Tiam1 and cdc42, in retinoblastoma and correlated these with clinicopathological parameters of the tumors.
Mohan, Adithi +4 more
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Trends in Microbiology, 1999
Phagocytosis is a major host defense mechanism that is mediated by at least two receptors in macrophages: complement receptor 3 (CR3) and the Fc γ receptors (Fc γRs). Caron and Hall have dissected the involvement of Rho, Rac and Cdc42 in FcγR- and CR3-mediated phagocytosis1xIdentification of two distinct mechanisms of phagocytosis controlled by ...
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Phagocytosis is a major host defense mechanism that is mediated by at least two receptors in macrophages: complement receptor 3 (CR3) and the Fc γ receptors (Fc γRs). Caron and Hall have dissected the involvement of Rho, Rac and Cdc42 in FcγR- and CR3-mediated phagocytosis1xIdentification of two distinct mechanisms of phagocytosis controlled by ...
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The p21Rac/Cdc42-activated kinases (PAKs)
The International Journal of Biochemistry & Cell Biology, 1998The p21-activated kinases (PAKs) are mammalian Rac/Cdc42-associated serine/threonine protein kinases. They contain diverse structural regulatory elements that allow them not only to participate as effectors in signaling processes initiated by activated GTPases but also in signal transduction events mediated by Src3 homology domains (SH3) or caspase ...
U G, Knaus, G M, Bokoch
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