Results 171 to 180 of about 37,980 (212)

The Novel ROCK Inhibitor Fasudil Derivative Fasudil-D-6h Prevents Tumour Progression by Regulating the Adherens Junction Signalling Pathway in Triple-Negative Breast Cancer. [PDF]

Breast Cancer (Dove Med Press)
Liang J, Tang M, Wang L.
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Spatially distinct FRL and Ena dependent actin networks coordinate nuclear positioning in Drosophila nurse cells. [PDF]

PLoS Genet
Gombos R, Farkas D, Vedelek B, Szikora S, Mihály J.   +4 more
europepmc   +1 more source

Targeting the neuro-immune crosstalk in breast cancer brain metastases. [PDF]

J Immunother Cancer
Zou Y, Wu J, Yuan Z, He X, Tang H.
europepmc   +1 more source

Mettl3-Mediated m6A Modification Represents a Novel Therapeutic Target for FSGS. [PDF]

Adv Sci (Weinh)
Zhu F, Li H, Li X, Du C, Wang T, Zhou X, Xie X, Shao Y, Huang Y, Hu Y, Guo X, Zhu B, Yu S, Zhang X, Zhao B.   +14 more
europepmc   +1 more source

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Cdc42: Role in Cancer Management

Chemical Biology & Drug Design, 2015
Contribution of Cdc42, a member of Rho family, has been characterized for the beginning of variety of cellular responses including cellular transformation, cell division, cell invasion, migration, invadopodia formation, enzyme activity, filopodia formation, and cell polarity in cells. Deregulation of Cdc42 can alter the normal functioning of the cells,
Muhammad Imran, Qadir, Amna, Parveen, Muhammad, Ali   +2 more
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NMR assignment of Cdc42(T35A), an active Switch I mutant of Cdc42

Biomolecular NMR Assignments, 2007
Cdc42(T35A) is an active construct of Cdc42, a Ras GTPase involved in signal transduction, containing a single-point mutation in an important effector-binding region. We determined the backbone and side chain resonance assignments of (13)C,(15)N-labelled Cdc42(T35A) from E. coli.
Adams, Paul D., Oswald, Robert E.
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Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro

Nature Chemical Biology, 2005
Inspired by the usefulness of small molecules to study membrane traffic, we used high-throughput synthesis and phenotypic screening to discover secramine, a molecule that inhibits membrane traffic out of the Golgi apparatus by an unknown mechanism. We report here that secramine inhibits activation of the Rho GTPase Cdc42, a protein involved in membrane
Henry E, Pelish, Jeffrey R, Peterson, Susana B, Salvarezza, Enrique, Rodriguez-Boulan, Ji-Long, Chen, Mark, Stamnes, Eric, Macia, Yan, Feng, Matthew D, Shair, Tomas, Kirchhausen   +9 more
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Regulation of anoikis by Cdc42 and Rac1

Experimental Cell Research, 2004
Ras family small GTPases play a critical role in malignant transformation, and Rho subfamily members contribute significantly to this process. Anchorage-independent growth and the ability to avoid detachment-induced apoptosis (anoikis) are hallmarks of transformed epithelial cells.
Tzu-Ling, Cheng, Marc, Symons, Tzuu-Shuh, Jou   +2 more
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Rac and Cdc42 Effectors

1999
Rac and Cdc42, like all members of the Ras superfamily, act as molecular switches, cycling between an inactive GDP-bound state and an active GTPbound state. Until recently, members of the Rho-subfamily were believed to be primarily involved in the regulation of cytoskeletal organization in response to extracellular growth factors. However, studies from
B, Boettner, L, Van Aelst
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Conformation of a Cdc42/Rac Interactive Binding Peptide in Complex with Cdc42 and Analysis of the Binding Interface

Biochemistry, 1999
Most of the putative effectors for the Rho-family small GTPases Cdc42 and Rac share a common sequence motif referred to as the Cdc42/Rac interactive binding (CRIB) motif. This sequence, with a consensus of I-S-x-P-(x)2-4-F-x-H-x-x-H-V-G [Burbelo, P. D., et al. (1995) J. Biol. Chem.
Stevens, W K, Vranken, W, Goudreau, N, Xiang, H, Xu, P, Ni, F   +5 more
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