Targeting Rac and Cdc42 GTPases in Cancer. [PDF]
Cancer Research, 2018 Rac and Cdc42 are small GTPases that have been linked to multiple human cancers and are implicated in epithelial to mesenchymal transition, cell-cycle progression, migration/invasion, tumor growth, angiogenesis, and oncogenic transformation.
María del Mar Maldonado +1 more
semanticscholar +3 more sources
Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. [PDF]
PLoS ONE, 2010 Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42.
Wenyu Bu +5 more
doaj +3 more sources
Cell division cycle protein 42-driven activation of the MKK3/6-p38 signaling pathway participates in cardiac remodeling in mice [PDF]
Cellular and Molecular Life SciencesCell division cycle protein 42 (Cdc42) is a member of the Rho GTPase subfamily that serves as a signal mediating factor in cell cycle division, cytoskeleton arrangement, cell polarization, membrane trafficking and signal transduction.
Ke Wen +15 more
doaj +2 more sources
Control of stress-activated Cdc42 dynamics by the MAP kinase Sty1—NDR kinase Orb6 regulatory axis [PDF]
iScienceSummary: Cdc42 is a Rho-family GTPase that controls cell polarization from yeast to human cells. In fission yeast, under normal growth conditions, Cdc42-GTP oscillates between cell tips to promote polarized growth.
Laura P. Doyle +4 more
doaj +2 more sources
Aging of human hematopoietic stem cells is linked to changes in Cdc42 activity
Haematologica, 2021 In this study, we characterize age-related phenotypes of human hematopoietic stem cells (HSC). We report increased frequencies of HSC, hematopoietic progenitor cells and lineage negative cells in the elderly but a decreased frequency of multi-lymphoid ...
Amanda Amoah +11 more
semanticscholar +1 more source
CDC42 regulates PYRIN inflammasome assembly [PDF]
Cell Reports, 2022 The PYRIN inflammasome pathway is part of the innate immune response against invading pathogens. Unprovoked continuous activation of the PYRIN inflammasome drives autoinflammation and underlies several autoinflammatory diseases, including familial Mediterranean fever (FMF) syndrome.
Lotte Spel +5 more
openaire +2 more sources
miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42 [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the role of microRNA-145 (miRNA-145) and microRNA-205 (miRNA-205) in proliferation and invasion of uveal melanoma (UM) cells. METHODS: The expression level of miRNA-145 and miRNA-205 from samples of UM patients were determined by ...
Yang Li +3 more
doaj +1 more source
Progress in the therapeutic inhibition of Cdc42 signalling
Biochemical Society Transactions, 2021 Cdc42 is a member of the Rho family of small GTPases and a key regulator of the actin cytoskeleton, controlling cell motility, polarity and cell cycle progression. It signals downstream of the master regulator Ras and is essential for cell transformation
N. P. Murphy, H. Mott, D. Owen
semanticscholar +1 more source
Cells, 2020 Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control.
Bo Zhang +4 more
doaj +1 more source
Mate and fuse: how yeast cells do it [PDF]
Open Biology, 2013 Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source.
Laura Merlini +2 more
doaj +1 more source