Results 11 to 20 of about 39,671 (187)
Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
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Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β
Journal of Integrative Neuroscience, 2022 Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li +10 more
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Cdc42 controls secretory granules morphology in rodent salivary glands in vivo
Communicative & Integrative Biology, 2020 We previously reported that the small GTPase Cdc42 negatively regulates endocytosis in the salivary gland of live mice. By using intravital subcellular microscopy, we showed that depletion of Cdc42 causes the mis-sorting of plasma membrane components ...
Akiko Shitara +2 more
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Mechanisms involved in the regulation of neuropeptide-mediated neurite outgrowth: a minireview
Endocrine Regulations, 2016 The present knowledge, regarding the neuronal growth and neurite extension, includes neuropeptide action in the central nervous system. Research reports have brought much information about the multiple intracellular signaling pathways of neuropeptides ...
Lestanova Z., Bacova Z., Bakos Jan
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Frontiers in Microbiology, 2021 Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan +10 more
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Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting. [PDF]
PLoS ONE, 2012 The ras proto-oncogene is one of the most frequently mutated genes in human cancer. However, given the prevalence of activating mutations in Ras and its association with aggressive forms of cancer, attempts to therapeutically target aberrant Ras ...
Kristy R Stengel, Yi Zheng
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Rho Family GTPases in Fission Yeast Cytokinesis
Communicative & Integrative Biology, 2019 During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow.
Brian Hercyk, Maitreyi Das
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Mitosis can drive cell cannibalism through entosis
eLife, 2017 Entosis is a form of epithelial cell cannibalism that is prevalent in human cancer, typically triggered by loss of matrix adhesion. Here, we report an alternative mechanism for entosis in human epithelial cells, driven by mitosis.
Joanne Durgan +7 more
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Stem Cell Research & Therapy, 2023 Background CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development.
Tao Zhou +6 more
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Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. [PDF]
PLoS ONE, 2010 Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42.
Wenyu Bu +5 more
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