A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature. [PDF]
PLoS ONE, 2018 The conserved Rho-family GTPase Cdc42 is a master regulator of polarity establishment in many cell types. Cdc42 becomes activated and concentrated in a region of the cell cortex, and recruits a variety of effector proteins to that site.
Christine N Daniels +2 more
doaj +2 more sources
Activation of Cdc42 GTPase upon CRY2-Induced Cortical Recruitment Is Antagonized by GAPs in Fission Yeast [PDF]
Cells, 2020 The small GTPase Cdc42 is critical for cell polarization in eukaryotic cells. In rod-shaped fission yeast Schizosaccharomyces pombe cells, active GTP-bound Cdc42 promotes polarized growth at cell poles, while inactive Cdc42-GDP localizes ubiquitously ...
Iker Lamas +2 more
doaj +2 more sources
Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. [PDF]
PLoS ONE, 2010 Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42.
Wenyu Bu +5 more
doaj +3 more sources
KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration. [PDF]
PLoS GeneticsThe small GTPase CDC42 promotes axon growth through actin filament polymerization and this growth is driven by axonal localization of the mRNA encoding the prenylated CDC42 isoform (Prenyl-Cdc42).
Matthew D Zdradzinski +13 more
doaj +2 more sources
Cdc42 interacts with chaperone Ydj1 to enhance its stability and partitioning during asymmetric cell division and aging in yeast. [PDF]
PLoS BiologyCdc42, a small GTPase essential for cell polarity, often becomes hyperactive with age and promotes senescence in yeast and animal cells. Yet, the mechanisms driving its age-related upregulation remain unclear.
Pil Jung Kang +3 more
doaj +2 more sources
Phosphorylation-dependent inhibition of Cdc42 GEF Gef1 by 14-3-3 protein Rad24 spatially regulates Cdc42 GTPase activity and oscillatory dynamics during cell morphogenesis [PDF]
, 2015 © The Author(s), 2015. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Molecular Biology of the Cell 26 (2015): 3520-3534, doi:10.1091/mbc.E15-02-0095.Active Cdc42 GTPase ...
Buchwald, Peter +8 more
core +3 more sources
CDC42 supports HBV entry by NTCP translocation to the plasma membrane and macropinocytosis [PDF]
EMBO ReportsCDC42 is a member of Rho GTPase family that regulates various biological processes and its activity can be hijacked by invading pathogens. Here, we discovered that the level of active CDC42 in hepatocytes positively correlates with the entry capacity of ...
Shuzhi Cui +6 more
doaj +2 more sources
miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42 [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the role of microRNA-145 (miRNA-145) and microRNA-205 (miRNA-205) in proliferation and invasion of uveal melanoma (UM) cells. METHODS: The expression level of miRNA-145 and miRNA-205 from samples of UM patients were determined by ...
Yang Li +3 more
doaj +1 more source
CDC42 regulates PYRIN inflammasome assembly [PDF]
Cell Reports, 2022 The PYRIN inflammasome pathway is part of the innate immune response against invading pathogens. Unprovoked continuous activation of the PYRIN inflammasome drives autoinflammation and underlies several autoinflammatory diseases, including familial Mediterranean fever (FMF) syndrome.
Lotte Spel +5 more
openaire +2 more sources
Mate and fuse: how yeast cells do it [PDF]
Open Biology, 2013 Many cells are able to orient themselves in a non-uniform environment by responding to localized cues. This leads to a polarized cellular response, where the cell can either grow or move towards the cue source.
Laura Merlini +2 more
doaj +1 more source