Cells, 2020 Rho GTPases, including Rho, Cdc42, Rac and ROP subfamilies, are key signaling molecules in RNA polymerase II (Pol II) transcriptional control.
Bo Zhang +4 more
doaj +1 more source
Zhongguo shuxue zazhi, 2023 Objective To explore critical regulatory genes in the hemoglobin switch process by analyzing transcriptomic data from the GSE6236, GSE17639 and GSE35102 datasets.
Jinchao WANG, Genhao ZHANG
doaj +1 more source
Targeting Cdc42 in cancer [PDF]
Expert Opinion on Therapeutic Targets, 2013 The Rho GTPases are a family of proteins that control fundamental cellular processes in response to extracellular stimuli and internal programs. Rho GTPases function as molecular switches in which the GTP-bound proteins are active and GDP-bound proteins are inactive.
Luis E, Arias-Romero, Jonathan, Chernoff
openaire +2 more sources
Cdc42 controls secretory granules morphology in rodent salivary glands in vivo
Communicative & Integrative Biology, 2020 We previously reported that the small GTPase Cdc42 negatively regulates endocytosis in the salivary gland of live mice. By using intravital subcellular microscopy, we showed that depletion of Cdc42 causes the mis-sorting of plasma membrane components ...
Akiko Shitara +2 more
doaj +1 more source
Gene targeting implicates Cdc42 GTPase in GPVI and non-GPVI mediated platelet filopodia formation, secretion and aggregation. [PDF]
PLoS ONE, 2011 Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation.
Huzoor Akbar +7 more
doaj +1 more source
Cdc42 is not essential for filopodium formation, directed migration, cell polarization, and mitosis in fibroblastoid cells [PDF]
, 2005 Udgivelsesdato: 2005-OctCdc42 is a small GTPase involved in the regulation of the cytoskeleton and cell polarity. To test whether Cdc42 has an essential role in the formation of filopodia or directed cell migration, we generated Cdc42-deficient ...
CZUCHRA, A +7 more
core +1 more source
Regulation of cell protrusions by small GTPases during fusion of the neural folds
eLife, 2016 Epithelial fusion is a crucial process in embryonic development, and its failure underlies several clinically important birth defects. For example, failure of neural fold fusion during neurulation leads to open neural tube defects including spina bifida.
Ana Rolo +8 more
doaj +1 more source
Cdc42 Promotes Axonogenesis of Primary Hippocampal Neurons by Inhibiting Glycogen Synthase Kinase-3β
Journal of Integrative Neuroscience, 2022 Background: Progressive axon degeneration is a common pathological feature of neurodegenerative diseases. Cdc42 is a member of the Rho GTPase family that participates in axonogenesis.
Yu-Ting Li +10 more
doaj +1 more source
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]
, 2017 PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson +82 more
core +3 more sources
Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
Frontiers in Physiology, 2023 The protein cell division cycle 42 (Cdc42) is a small GTPase of the Rho family regulating a plethora of physiological functions in a tissue, cell and subcellular-specific manner via participating in multiple signaling pathways.
Alexander Wirth, Evgeni Ponimaskin
doaj +1 more source