Results 21 to 30 of about 4,383 (155)
Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5901-5916, December 2022., 2022 Abstract The transformation biology of secondary acute myeloid leukaemia (AML) from myelodysplastic syndromes (MDSs) is still not fully understood. We performed paired self‐controlled sequencing, including targeted, whole exome, and single‐cell RNA sequencing, in a cohort of MDS patients to search for AML transformation‐related mutations (TRMs). Thirty‐
Feng Xu +5 more
wiley +1 more source
Frontiers in Microbiology, 2021 Hepatitis E Virus (HEV) causes viral hepatitis in humans worldwide, while a subset of HEV species, avian HEV, causes hepatitis-splenomegaly syndrome in chickens.
Mengnan Fan +10 more
doaj +1 more source
Molecular Microbiology, Volume 118, Issue 6, Page 623-636, December 2022., 2022 In host‐pathogen interactions, actin‐cytoskeletal dynamics play a crucial role in successful adherence, invasion, and intracellular motility by many intruding microbes. To achieve this goal, bacterial pathogens target major host regulators, one of which is the key actin‐binding protein and class‐II actin nucleation‐promoting factor cortactin.
Irshad Sharafutdinov +4 more
wiley +1 more source
Spots, strips, and spiral waves in models for static and motile cells [PDF]
J. Math. Biol. 82, 28 (2021), 2019 The polarization and motility of eukaryotic cells depends on assembly and contraction of the actin cytoskeleton and its regulation by proteins called GTPases. The activity of GTPases causes assembly of filamentous actin (by GTPases Cdc42, Rac), resulting in protrusion of the cell edge.
arxiv +1 more source
Essential role of Cdc42 in Ras-induced transformation revealed by gene targeting. [PDF]
PLoS ONE, 2012 The ras proto-oncogene is one of the most frequently mutated genes in human cancer. However, given the prevalence of activating mutations in Ras and its association with aggressive forms of cancer, attempts to therapeutically target aberrant Ras ...
Kristy R Stengel, Yi Zheng
doaj +1 more source
Cell-cell and cell-matrix adhesion in survival and metastasis: Stat3 versus Akt
Biomolecular Concepts, 2015 Both cell-cell and cell-matrix adhesion are important for epithelial cell differentiation and function. Classical cadherins mediate cell to cell interactions and are potent activators of the signal transducer and activator of transcription (Stat3 ...
Niit Maximilian +6 more
doaj +1 more source
Stem Cell Research & Therapy, 2023 Background CDC42 is a member of Rho GTPase family, acting as a molecular switch to regulate cytoskeleton organization and junction maturation of epithelium in organ development.
Tao Zhou +6 more
doaj +1 more source
Rho GTPases and their downstream effectors in megakaryocyte biology
Platelets, 2019 Megakaryocytes differentiate from hematopoietic stem cells in the bone marrow. The transition of megakaryocytes to platelets is a complex process. Thereby, megakaryocytes extend proplatelets into sinusoidal blood vessels, where the proplatelets undergo ...
Irina Pleines +2 more
doaj +1 more source
Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. [PDF]
PLoS ONE, 2010 Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42.
Wenyu Bu +5 more
doaj +1 more source
A simple reaction-diffusion system as a possible model for the origin of chemotaxis [PDF]
arXiv, 2022 Chemotaxis is a directed cell movement in response to external chemical stimuli. In this paper, we propose a simple model for the origin of chemotaxis - namely how a directed movement in response to an external chemical signal may occur based on purely reaction-diffusion equations reflecting inner working of the cells. The model is inspired by the well-
arxiv