Results 51 to 60 of about 81,267 (316)

Cdc42 - the centre of polarity [PDF]

Journal of Cell Science, 2004
All cell types polarize, at least transiently, during division or to generate specialized shapes and functions. This capacity extends from yeast to mammals, and it is now clear that many features of the molecular mechanisms controlling polarization are conserved in all eukaryotic cells.
openaire   +3 more sources

Infantile Myelofibrosis and Myeloproliferation with CDC42 Dysfunction [PDF]

Journal of Clinical Immunology, 2020
AbstractStudies of genetic blood disorders have advanced our understanding of the intrinsic regulation of hematopoiesis. However, such genetic studies have only yielded limited insights into how interactions between hematopoietic cells and their microenvironment are regulated.
Inga Hofmann, Inga Hofmann, Alan B. Cantor, Genevieve M. Crane, Mitsutoshi Nakamura, Thomas E. Akie, Nour J. Abdulhay, Nour J. Abdulhay, Haydar Frangoul, Dilnar Mahmut, Dilnar Mahmut, Susan M. Parkhurst, Meghan E. Kapp, Vijay G. Sankaran, Vijay G. Sankaran, Namrata Gupta, Satish K. Nandakumar, Satish K. Nandakumar, Stacey Gabriel, David A. Williams, Jeffrey M. Verboon, Jeffrey M. Verboon, Daryl E. Klein, Becky Manes, Amy E. Geddis, Ah Ram Kim, Ah Ram Kim   +26 more
openaire   +3 more sources

Vascular endothelial growth factor‐C in activating vascular endothelial growth factor receptor‐3 and chemokine receptor‐4 in melanoma adhesion

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5743-5754, December 2022., 2022
Abstract Vascular endothelial growth factor‐C (VEGF‐C) binds to receptor vascular endothelial growth factor receptor‐3 (VEGFR‐3) expressed on lymphatic endothelial and melanoma cells. Binding of VEGF‐C to VEGFR‐3 enhances receptor phosphorylation that activates mitogen‐activated protein kinase (MAP‐K) and phosphatidylinositol‐3‐kinase (PI3K).
Yvette N. Hlophe, Anna M. Joubert
wiley   +1 more source

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]

, 2017
PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson, Anthony, Barnes, Boehm, Boisvert, Bos, Campbell, Cantley, Capes-Davis, Caserta, Clevers, Corbalán-García, Crossman, Deevi, Deevi, Dubois, Dubois, Durgan, Décaillot, Eisenmann, Enslen, Eroglu, Furia, Ge, Glover, Hanahan, Hao, Hietakangas, Irazoqui, Jaffe, Jagan, Jagan, Jia, Johnston, Klompstra, Kovacs, Kumari, Lee, Lee, Leslie, Li, Lima-Fernandes, Lima-Fernandes, Liu Tj, Luttrell, Ma, Magudia, Maier, Martin-Belmonte, Meitinger, Meuillet, Misticone, Morin, Nagasaki, Naguib, Naguib, Narbonne, Noda, Ogg, Oh, Pertz, Pálmer, Raftopoulou, Raftopoulou, Rahdar, Rock, Rouault, Salmena, Sanchez, Sato, Shukla, Slorach, Smith, Song, Song, Söderberg, Tait, Torres, Ueda, Urs, Walker, Weng, Yun   +82 more
core   +3 more sources

The first buds of Cdc42 [PDF]

Journal of Cell Biology, 2015
In 1990, John Pringle and colleagues identified the small GTPase and demonstrated its role in yeast cell polarization.
openaire   +3 more sources

The PI3K inhibitor pictilisib and the multikinase inhibitors pazopanib and sorafenib have an impact on Rac1 level and migration of medulloblastoma in vitro

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5832-5845, December 2022., 2022
Abstract Metastatic disease is the leading cause of death in children suffering from medulloblastoma and a major treatment challenge. The evidence of leptomeningeal dissemination defines the most aggressive tumours and is associated with increased mortality; thus, inhibition of migration as a factor involved in the process of metastatic disease is ...
Leonie F. Schoen, Rogerio B. Craveiro, Torsten Pietsch, Thomas Moritz, Anja Troeger, Silvia Jordans, Dagmar Dilloo   +6 more
wiley   +1 more source

Novel regulation of mitotic exit by the Cdc42 effectors Gic1 and Gic2 [PDF]

, 2004
Copyright @ The Rockefeller University PressThe guanine nucleotide exchange factor Cdc24, the GTPase Cdc42, and the Cdc42 effectors Cla4 and Ste20, two p21-activated kinases, form a signal transduction cascade that promotes mitotic exit in yeast.
Höfken, T, Schiebel, E
core   +2 more sources

Identification of the Region in Cdc42 That Confers the Binding Specificity to Activated Cdc42-associated Kinase [PDF]

Journal of Biological Chemistry, 2004
The Rho family small G-protein Cdc42 has been implicated in a diversity of biological functions. Multiple downstream effectors have been identified. How Cdc42 discriminates the interaction with its multiple downstream effectors is not known. Activated Cdc42-associated tyrosine kinase (ACK) is a very specific effector of Cdc42.
Wannian Yang, Yan Gu, Qiong Lin, Chandra Childress   +3 more
openaire   +3 more sources

Somatic mutations of activating signalling, transcription factor, and tumour suppressor are a precondition for leukaemia transformation in myelodysplastic syndromes

Journal of Cellular and Molecular Medicine, Volume 26, Issue 23, Page 5901-5916, December 2022., 2022
Abstract The transformation biology of secondary acute myeloid leukaemia (AML) from myelodysplastic syndromes (MDSs) is still not fully understood. We performed paired self‐controlled sequencing, including targeted, whole exome, and single‐cell RNA sequencing, in a cohort of MDS patients to search for AML transformation‐related mutations (TRMs). Thirty‐
Feng Xu, Lin‐Yun Wu, Juan Guo, Qi He, Zheng Zhang, Xiao Li   +5 more
wiley   +1 more source

Energetic constraints on filament mediated cell polarization [PDF]

, 2021
Cell polarization underlies many cellular processes, such as differentiation, migration, and budding. Many living cells, such as budding yeast and fission yeast, use cytoskeletal structures to actively transport proteins to one location on the membrane and create a high density spot of membrane-bound proteins.
arxiv   +1 more source