Results 71 to 80 of about 37,980 (212)

Epstein-Barr virus-encoded LMP1 interacts with FGD4 to activate Cdc42 and thereby promote migration of nasopharyngeal carcinoma cells. [PDF]

PLoS Pathogens, 2012
Epstein-Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC), a human malignancy notorious for its highly metastatic nature. Among EBV-encoded genes, latent membrane protein 1 (LMP1) is expressed in most NPC tissues and exerts ...
Hao-Ping Liu, Chia-Chun Chen, Chih-Ching Wu, Yi-Chuan Huang, Shu-Chen Liu, Ying Liang, Kai-Ping Chang, Yu-Sun Chang   +7 more
doaj   +1 more source

SPECs, Small Binding Proteins for Cdc42 [PDF]

Journal of Biological Chemistry, 2000
The Rho GTPase, Cdc42, regulates a wide variety of cellular activities including actin polymerization, focal complex assembly, and kinase signaling. We have identified a new family of very small Cdc42-binding proteins, designated SPECs (for Small Protein Effector of Cdc42), that modulates these regulatory activities.
D M, Pirone, S, Fukuhara, J S, Gutkind, P D, Burbelo   +3 more
openaire   +2 more sources

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Relation of CDC42, Th1, Th2, and Th17 cells with cognitive function decline in Alzheimer's disease

Annals of Clinical and Translational Neurology, 2022
Objective Cell division cycle 42 (CDC42) regulates neurite outgrowth, neurotransmitter, and T help (Th) cell‐mediated neuroinflammation, while its clinical implication in Alzheimer's disease (AD) is not clear.
Yi Zhang, Chenglin Niu
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia

Genes and Diseases
CDC42 controls intestinal epithelial (IEC) stem cell (IESC) division. How aberrant CDC42 initiates intestinal inflammation or neoplasia is unclear. We utilized models of inflammatory bowel diseases (IBD), colorectal cancer, aging, and IESC injury to ...
Dongsheng Zhang, Wenjuan Tang, Haitao Niu, William Tse, Hai-Bin Ruan, Helmut Dolznig, Thomas Knösel, Friedrich Karl-Heinz, Madeleine Themanns, Jiang Wang, Mingquan Song, Lee Denson, Lukas Kenner, Richard Moriggl, Yi Zheng, Xiaonan Han   +15 more
doaj   +1 more source

Cdc42 and aging of hematopoietic stem cells [PDF]

Current Opinion in Hematology, 2013
Hematopoietic stem cells (HSCs) continuously provide mature blood cells during the lifespan of a mammal. The functional decline in hematopoiesis in the elderly, which involves a progressive reduction in the immune response and an increased incidence of myeloid malignancy, is partly linked to HSC aging.
Hartmut, Geiger, Yi, Zheng
openaire   +2 more sources

The RNA‐Binding Protein PARN Remodeled 3′ UTR Structure Defines Poly(A)‐Loading Sites to Mediate Immunoglobulin Homeostasis

Advanced Science, EarlyView.
ABSTRACT Class Switch Recombination (CSR) is essential for generating high‐affinity antibody isotypes from IgM during adaptive humoral responses. Despite well‐established roles for various transcription factors, whether CSR is subject to dedicated post‐transcriptional control represents a significant gap in knowledge.
Siyuan Sun, Chen Yang, Xiaoyu Wang, Naijing Hu, Shengyao Zhang, Xinchun Li, Yu Chen, Jianan Zhai, Xiangfeng Tang, Wei Lu, Chenxu Lu, Changchang Cao, Weiru Yu, Wenhao Wu, Xiaonan Nie, Fengchao Wang, Bing Fang, Fazheng Ren, Yixuan Li, Juan Chen   +19 more
wiley   +1 more source

Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. [PDF]

PLoS ONE, 2011
Cdc42 of the Rho GTPase family has been implicated in cell actin organization, proliferation, survival, and migration but its physiological role is likely cell-type specific.
Fukun Guo, Shuangmin Zhang, Pulak Tripathi, Jochen Mattner, James Phelan, Alyssa Sproles, Jun Mo, Marsha Wills-Karp, H Leighton Grimes, David Hildeman, Yi Zheng   +10 more
doaj   +1 more source

Vav2 Is an Activator of Cdc42, Rac1, and RhoA [PDF]

Journal of Biological Chemistry, 2000
Vav and Vav2 are members of the Dbl family of proteins that act as guanine nucleotide exchange factors (GEFs) for Rho family proteins. Whereas Vav expression is restricted to cells of hematopoietic origin, Vav2 is widely expressed. Although Vav and Vav2 share highly related structural similarities and high sequence identity in their Dbl homology ...
K, Abe, K L, Rossman, B, Liu, K D, Ritola, D, Chiang, S L, Campbell, K, Burridge, C J, Der   +7 more
openaire   +2 more sources