Results 71 to 80 of about 86,770 (308)
Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
Journal of Biological Chemistry, 2018 Inflammation is a major driver of tumor progression and metastasis, although the mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown.
G. Razidlo, Kevin M Burton, M. McNiven
semanticscholar +1 more source
Cdc42 Regulates Microtubule-Dependent Golgi Positioning [PDF]
Traffic, 2010 The molecular mechanisms underlying cytoskeleton-dependent Golgi positioning are poorly understood. In mammalian cells, the Golgi apparatus is localized near the juxtanuclear centrosome via dynein-mediated motility along microtubules. Previous studies implicate Cdc42 in regulating dynein-dependent motility.
Heidi, Hehnly +3 more
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Effects of cdc42 gene knockout by CRISPR/Cas9 technology on osteochondral development in zebrafish
陆军军医大学学报Objective To knock out cdc42 gene in zebrafish using CRISPR/Cas9 technology, and investigate the effect of cdc42 on early osteochondral development.
YANG Yunfei, LI Yi, SUN Xianding
doaj +1 more source
Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry. [PDF]
, 2015 Spontaneous polarization without spatial cues, or symmetry breaking, is a fundamental problem of spatial organization in biological systems. This question has been extensively studied using yeast models, which revealed the central role of the small ...
Martin, S.G.
core +2 more sources
Optogenetic dissection of Rac1 and Cdc42 gradient shaping
Nature Communications, 2018 During cell migration, Rho GTPases spontaneously form spatial gradients that define the front and back of cells. At the front, active Cdc42 forms a steep gradient whereas active Rac1 forms a more extended pattern peaking a few microns away.
Simon de Beco +7 more
semanticscholar +1 more source
The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential
Aging and Cancer, EarlyView.As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley +1 more source
NNVA: Neural Network Assisted Visual Analysis of Yeast Cell Polarization Simulation
, 2019 Complex computational models are often designed to simulate real-world physical phenomena in many scientific disciplines. However, these simulation models tend to be computationally very expensive and involve a large number of simulation input parameters
Chou, Ching-Shan +4 more
core +1 more source
Cancer Biology & Therapy, 2019 Cdc42 is a member of the Rho family of small GTPases that are at the crossroads of major oncogenic signaling pathways involved in both lung and prostate cancers.
Byron J. Aguilar +5 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu +4 more
wiley +1 more source