Results 71 to 80 of about 81,267 (316)

Cdc42 interaction with N-WASP and Toca-1 regulates membrane tubulation, vesicle formation and vesicle motility: implications for endocytosis. [PDF]

PLoS ONE, 2010
Transducer of Cdc42-dependent actin assembly (Toca-1) consists of an F-BAR domain, a Cdc42 binding site and an SH3 domain. Toca-1 interacts with N-WASP, an activator of actin nucleation that binds Cdc42.
Wenyu Bu, Kim Buay Lim, Yuan Hong Yu, Ai Mei Chou, Thankiah Sudhaharan, Sohail Ahmed   +5 more
doaj   +1 more source

Inhibition of Cdc42 during mitotic exit is required for cytokinesis [PDF]

, 2014
The role of Cdc42 and its regulation during cytokinesis is not well understood. Using biochemical and imaging approaches in budding yeast, we demonstrate that Cdc42 activation peaks during the G1/S transition and during anaphase but drops during mitotic ...
Atkins, Benjamin D., Lew, Daniel J., Pellman, David, Saito, Koji, Wu, Chi-Fang, Yoshida, Satoshi   +5 more
core   +1 more source

Cdc42: A Novel Regulator of Insulin Secretion and Diabetes-Associated Diseases

International Journal of Molecular Sciences, 2019
Cdc42, a member of the Rho GTPases family, is involved in the regulation of several cellular functions including cell cycle progression, survival, transcription, actin cytoskeleton organization and membrane trafficking.
Qi-Yuan Huang, Xing-Ning Lai, X. Qian, Lin-Chen Lv, Jun Li, Jing Duan, Xing-Hua Xiao, Li-Xia Xiong   +7 more
semanticscholar   +1 more source

RhoG Signals in Parallel with Rac1 and Cdc42 [PDF]

Journal of Biological Chemistry, 2002
RhoG is a member of the Rho family of small GTPases and shares high sequence identity with Rac1 and Cdc42. Previous studies suggested that RhoG mediates its effects through activation of Rac1 and Cdc42. To further understand the mechanism of RhoG signaling, we studied its potential activation pathways, downstream signaling properties, and functional ...
Keith Burridge, Krister Wennerberg, Antoine E. Karnoub, Channing J. Der, Rong Yu Liu, Shawn M. Ellerbroek   +5 more
openaire   +2 more sources

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

Optogenetics reveals Cdc42 local activation by scaffold-mediated positive feedback and Ras GTPase

bioRxiv, 2019
The small GTPase Cdc42 is critical for cell polarization. Scaffold-mediated positive feedback regulation was proposed to mediate symmetry-breaking to a single active zone in budding yeast cells. In rod-shaped fission yeast S.
Iker Lamas, L. Merlini, Aleksandar Vještica, Vincent Vincenzetti, Sophie G. Martin   +4 more
semanticscholar   +1 more source

Pattern localization to a domain edge [PDF]

Phys. Rev. E 101, 022414 (2020), 2019
The formation of protein patterns inside cells is generically described by reaction-diffusion models. The study of such systems goes back to Turing, who showed how patterns can emerge from a homogenous steady state when two reactive components have different diffusivities (e.g. membrane-bound and cytosolic states). However, in nature, systems typically
arxiv   +1 more source

Regulation of polarised growth in fungi [PDF]

, 2008
Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo, Adamo, Adams, Akashi, Ayad-Durieux, Bachewich, Bartnicki-Garcia, Bartnicki-Garcia, Bassilana, Bassilana, Bassilana, Behrens, Berman, Bidlingmaier, Bose, Boyce, Boyce, Boyce, Boyd, Brown, Caviston, Chant, Chapa y Lazo, Collinge, Colman-Lerner, Court, Crampin, Cvrckova, Dong, Drgonova, Dunkler, Feng, Finger, France, Gao, Girbardt, Gladfelter, Goehring, Gorovits, Gulli, Guo, Harris, Harris, Hartwell, Hergovich, Hou, Hou, Irazoqui, Jin, Karnoub, Knechtle, Kohno, Konzack, Kron, Leberer, Leberer, Leberer, Leonhard, Lew, Li, Liu, Loeb, Loeb, Longtine, Mahlert, Mata, McCollum, McCusker, Medkova, Mehta, Mendenhall, Nelson, Nonaka, Novick, Pan, Park, Pearson, Peter, Peter E. Sudbery, Philippsen, Punt, Qadota, Racki, Read, Santangelo, Schmidt, Seiler, Seiler, Sinha, Smith, Soll, Stevenson, Sudbery, Sudbery, Sudbery, Tamaskovic, Tanaka, Tcheperegine, Trinci, Verde, Versele, Virag, Virag, Walton, Walworth, Wedlich-Soldner, Wedlich-Soldner, Wendland, Wu, Yarden, Zhang, Zheng, Zheng   +112 more
core   +1 more source

Clinical significance of serum CDC42 in the prediction of uremic vascular calcification incidence and progression

Libyan Journal of Medicine, 2023
Vascular calcification (VC) is prevalent in uremia patients, lacking effective molecular biomarkers. This study was conducted to explore the role of serum cell division cycle 42 (CDC42) in the diagnosis of uremic VC incidence and progression. We enrolled
Mingzhi Xu, Mingjiao Pan, Na An, Ruman Chen, Yafei Bai, Jiqing He, Chunli Wang, Yonghui Qi   +7 more
doaj   +1 more source

Dynamics of membranes driven by actin polymerization [PDF]

, 2005
A motile cell, when stimulated, shows a dramatic increase in the activity of its membrane, manifested by the appearance of dynamic membrane structures such as lamellipodia, filopodia and membrane ruffles. The external stimulus turns on membrane bound activators, like Cdc42 and PIP2, which cause increased branching and polymerization of the actin ...
arxiv   +1 more source