British Journal of Pharmacology, EarlyView.Ageing brings about various biochemical, structural and mechanical alterations within tissues, profoundly impacting cellular behaviour and function. One of the hallmark changes observed with ageing is an increase in cellular microenvironment stiffness, a biomechanical property influenced by intrinsic factors within the cell and extrinsic factors from ...
Wang HaiYang +3 more
wiley +1 more source
Tumour Cell Size Control and Its Impact on Tumour Cell Function
Cell Proliferation, EarlyView.The regulatory mechanism of the size of tumour cells and its impact on the functions of tumour cells, as well as a summary of potential therapeutic targets for the corresponding mechanisms. ABSTRACT Cell size is an important component of cell morphological characteristics.
Min Zhou, Mei Zhou, Yang Jin
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Turnover and bypass of p21-activated kinase during Cdc42-dependent MAPK signaling in yeast [PDF]
, 2023 Beatriz González +6 more
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Decoding the Role of Caveolin‐1 in Morphological Diversity and Self‐Renewal of Breast Cancer Cells
Cell Proliferation, EarlyView.The silence of caveolin‐1 (Cav‐1) reproduced the morphological evolutionary behaviour of cancer cells, which is similar to the epithelial‐mesenchymal transition process. And Cav‐1 dependent morphological changes could affect cancer cell self‐renewal capacity through maintaining the morphological stability.
Shun Li +14 more
wiley +1 more source
Focus on Cdc42 in Breast Cancer: New Insights, Target Therapy Development and Non-Coding RNAs
Cells, 2019 Breast cancer is the most common malignant tumors in females. Although the conventional treatment has demonstrated a certain effect, some limitations still exist.
Yu Zhang +5 more
doaj +1 more source
Involvement of Cdc42 Signaling in ApoA-I-induced Cholesterol Efflux [PDF]
, 2003 Jerzy–Roch Nofer +5 more
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CDC42—a promising target of glioma treatment related to Treg cell proliferation [PDF]
, 2023 Tao Jiang +3 more
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Tks5 interactome reveals endoplasmic‐reticulum‐associated translation machinery in invadosomes
The FEBS Journal, EarlyView.Invadosomes—dynamic structures enabling matrix invasion—include rosettes, dots, and linear forms, depending on cell type and context. Using the invadosome marker Tks5 (SH3PXD2A), we identified shared molecular features across cell types. Mass spectrometry revealed components of the translation machinery, notably EIF4B, and ER‐associated proteins within
Léa Normand +11 more
wiley +1 more source
Differential GAP requirement for Cdc42-GTP polarization during proliferation and sexual reproduction [PDF]
, 2018 Daniela Gallo Castro, Sophie G. Martin
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A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source