A simple reaction-diffusion system as a possible model for the origin of chemotaxis [PDF]
arXiv, 2022 Chemotaxis is a directed cell movement in response to external chemical stimuli. In this paper, we propose a simple model for the origin of chemotaxis - namely how a directed movement in response to an external chemical signal may occur based on purely reaction-diffusion equations reflecting inner working of the cells. The model is inspired by the well-
arxiv
Spontaneous cell polarization: Feedback control of Cdc42 GTPase breaks cellular symmetry. [PDF]
, 2015 Spontaneous polarization without spatial cues, or symmetry breaking, is a fundamental problem of spatial organization in biological systems. This question has been extensively studied using yeast models, which revealed the central role of the small ...
Martin, S.G.
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Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42
Journal of Biological Chemistry, 2018 Inflammation is a major driver of tumor progression and metastasis, although the mechanisms by which proinflammatory cytokines drive metastatic invasion are unknown.
G. Razidlo, Kevin M Burton, M. McNiven
semanticscholar +1 more source
Cdc42 in oncogenic transformation, invasion, and tumorigenesis [PDF]
Cellular Signalling, 2011 The Rho family of GTPases represents a class of Ras-related signaling molecules often deregulated in cancer. Rho GTPases switch from a GDP-bound, inactive state to a GTP-bound, active state in response to extracellular stimuli such as mitogens and extracellular matrix.
Kristy R. Stengel, Yi Zheng
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Matrix rigidity regulates spatiotemporal dynamics of Cdc42 activity and vacuole formation kinetics of endothelial colony forming cells [PDF]
, 2014 Recent evidence has shown that endothelial colony forming cells (ECFCs) may serve as a cell therapy for improving blood vessel formation in subjects with vascular injury, largely due to their robust vasculogenic potential.
Cho, Eunhye +6 more
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Global well-posedness for volume-surface reaction-diffusion systems [PDF]
arXiv, 2021 We study the global existence of classical solutions to volume-surface reaction-diffusion systems with control of mass. Such systems appear naturally from modeling evolution of concentrations or densities appearing both in a volume domain and its surface, and therefore have attracted considerable attention.
arxiv
The Rho GDI Rdi1 regulates Rho GTPases by distinct mechanisms [PDF]
, 2008 © 2008 by The American Society for Cell Biology. Under the License and Publishing Agreement, authors grant to the general public, effective two months after publication of (i.e.,.
Ammerer G. +58 more
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IQGAP1 Is a Component of Cdc42 Signaling to the Cytoskeleton [PDF]
Journal of Biological Chemistry, 2002 The Ras-GAP related protein IQGAP1 binds several proteins, including actin, calmodulin, E-cadherin and the Rho family GTPase Cdc42. To gain insight into its in vivo function, IQGAP1 was overexpressed in mammalian cells. Transfection of IQGAP1 significantly increased the levels of active, GTP-bound Cdc42, resulting in the formation of peripheral actin ...
David B. Sacks +2 more
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Rho Family GTPases in Fission Yeast Cytokinesis
Communicative & Integrative Biology, 2019 During cytokinesis, actomyosin ring constriction drives furrow formation. In animal cells, Rho GTPases drive this process through the positioning and assembly of the actomyosin ring, and through extracellular matrix remodeling within the furrow.
Brian Hercyk, Maitreyi Das
doaj +1 more source
Self-organization principles of intracellular pattern formation [PDF]
, 2018 Dynamic patterning of specific proteins is essential for the spatiotemporal regulation of many important intracellular processes in procaryotes, eucaryotes, and multicellular organisms. The emergence of patterns generated by interactions of diffusing proteins is a paradigmatic example for self-organization. In this article we review quantitative models
arxiv +1 more source