Results 161 to 170 of about 8,832 (194)

Cell cycle regulation has shaped replication origins in budding yeast. [PDF]

Nat Struct Mol Biol
Lim CT, Miller TCR, Tan KW, Talele S, Early A, East P, Sánchez H, Dekker NH, Costa A, Diffley JFX.   +9 more
europepmc   +1 more source

MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis. [PDF]

Nat Commun
Faull SV, Barbon M, Mossler A, Yuan Z, Bai L, Reuter LM, Riera A, Winkler C, Magdalou I, Peach M, Li H, Speck C.   +11 more
europepmc   +1 more source

How similar are the molecular mechanisms of yeast and metazoan genome replication initiation? [PDF]

Biochem Soc Trans
Palm G, Costa A.
europepmc   +1 more source

Compact Origins and Where to Find Them: ORC's Guide to Genome-Wide Licensing. [PDF]

Bioessays
Speck C, Reuter LM.
europepmc   +1 more source

The Anti-Apoptotic Protein Lifeguard Is Expressed in Osteosarcoma, Chondrosarcoma, and Soft Tissue Sarcoma.

Oncology
Senger S, Schlottmann F, Strauß S, Vogt PM, Bucan V.   +4 more
europepmc   +1 more source

Regulation of the localization and stability of Cdc6 in living yeast cells

Biochemical and Biophysical Research Communications, 2003
The Cdc6 protein is an essential regulator for initiation of DNA replication. Following the G1/S transition, Cdc6 is degraded through a ubiquitin-mediated proteolysis pathway. In this study, we tagged Cdc6 with green fluorescent protein (GFP) and used site-specific mutations to study the regulation of Cdc6 localization and degradation in living yeast ...
Kathy Qian Luo, Donald C Chang, Judith L Campbell   +2 more
exaly   +5 more sources

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Cdc6 knockdown inhibits human neuroblastoma cell proliferation

Molecular and Cellular Biochemistry, 2008
The cell division controller Cdc6 plays a central role in the initiation of DNA replication. It was found that elevated levels of Cdc6 were present in many of human cancer cells, and the accumulation of Cdc6 is required for cell proliferation. In this study, we have investigated the control of Cdc6 expression and its effect on cell proliferation and ...
Robert C Seeger, Nino Keshelava, Ambrose Jong   +2 more
exaly   +3 more sources

Multiple, short protein binding motifs in ORC1 and CDC6 control the initiation of DNA replication

Molecular Cell, 2021
The initiation of DNA replication involves cell cycle-dependent assembly and disassembly of protein complexes, including the origin recognition complex (ORC) and CDC6 AAA+ ATPases.
Manzar Hossain, Kuhulika Bhalla, Bruce Stillman   +2 more
exaly   +4 more sources

Interaction trap experiment with CDC6

Pflügers Archiv - European Journal of Physiology, 2000
CDC6 is an essential gene of yeast Saccharomyces cerevisiae. Although DNA sequence of the gene is available for a long time, biochemical function of Cdc6 protein in the cell cycle remains unclear. Using the interaction trap experiment we were looking for proteins interacting specifically with Cdc6. Four gene products interacting with Cdc6 were detected.
P B, Zavec, A, Comino, P, Watt, R, Komel
openaire   +3 more sources