Results 141 to 150 of about 8,832 (194)

PIK75 effectively reverses PI3K‒AKT activation caused by palbociclib resistance and synergistically inhibits the progression of esophageal squamous cell carcinoma. [PDF]

Sci Rep
Zhao Y, Li L, Jiang Y, Sun Y, Xu Y, Ye X, Zhang F, Zhu F, Pan Y, Ma S.   +9 more
europepmc   +1 more source

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics. [PDF]

Nat Commun
Sosenko Piscitello A, Nilsson AS, Hawgood M, Sayyid AH, Dionellis VS, Giglio G, Urién B, Bajgain P, Ntallis SG, Bartek J, Halazonetis TD, Lemmens B.   +11 more
europepmc   +1 more source

Geminin inhibits DNA replication licensing by sterically blocking CDT1-MCM2 interactions. [PDF]

Nat Commun
Tomkins J, Edwardes LV, Faull SV, Peach M, Gillespie PJ, Leber V, Schmidt A, Bounoua H, Sim N, Camarillo R, Blow JJ, Barr AR, Barnard A, Speck C.   +13 more
europepmc   +1 more source

The DNA replication machinery transmits dual signals to prevent unscheduled licensing and execution of centrosome duplication. [PDF]

Nat Commun
Matsuhashi K, Ito KK, Nagai K, Sanada A, Watanabe K, Takumi K, Toyoda A, Fukuyama M, Yamamoto S, Chinen T, Stewart GS, Hata S, Kitagawa D.   +12 more
europepmc   +1 more source

SETDB1 is critically required for uveal melanoma growth and represents a promising therapeutic target. [PDF]

Cell Death Dis
Krossa I, Pisibon C, Cheli Y, Bille K, Dalmasso M, Hamadat S, Husser C, Irondelle M, Cherfils-Vicini J, Soysouvanh F, Nahon-Esteve S, Martel A, Lassalle S, Caujolle JP, Maschi C, Baillif S, Hasson D, Carcamo S, Aplin AE, Davidson I, Bernstein E, Naim V, Ballotti R, Bertolotto C, Strub T.   +24 more
europepmc   +1 more source

The GGH/HuR Complex Binds and Stabilizes mRNAs to Maintain Tumor Cell Cycle and DNA Replication. [PDF]

Adv Sci (Weinh)
Li Y, Li X, Du Y, Chen S, He X, Xie Z, Zhou Z, Zhao H, Zeng X, Chen G.   +9 more
europepmc   +1 more source

Aneuploidy alleviates the cell proliferation defect caused by mutations affecting origin licensing in Saccharomyces cerevisiae. [PDF]

PLoS Genet
de La Roche Saint-André C.
europepmc   +1 more source

Integrated machine learning and single-cell analysis identify chromatin-remodeling gene signature for diagnosis and prognosis in nasopharyngeal carcinoma. [PDF]

Clin Exp Med
Chang Y, Qin W, Chen W, Yan Z, Xu Y, Ma S, Zhu X.   +6 more
europepmc   +1 more source

Transcriptome profiling of human dermal MDPL fibroblasts reveals a characteristic molecular signature providing insights into pathogenic mechanisms. [PDF]

J Mol Med (Berl)
Murdocca M, Pepe G, Maccaroni S, Spitalieri P, Helmer-Citterich M, Novelli G, Sangiuolo F.   +6 more
europepmc   +1 more source

BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex function. [PDF]

Proc Natl Acad Sci U S A
Pappas K, Ferrari M, Smith P, Nandakumar S, Khan Z, Young SB, LaClair J, Russo MV, Huang-Hobbs E, Schultz N, Abida W, Karthaus W, Jasin M, L Sawyers C.   +13 more
europepmc   +1 more source