Results 121 to 130 of about 8,832 (194)
Mutations at the GSK-3 consensus site in Cdc6 play a role in Cdc6p stability.
, 2012 (A) GSK-3 and CDK consensus sites in the Cdc6 C-terminal region were shown as a red and blue line, respectively. (B) The pRS426 (control plasmid), CDC6 or CDC6T368A S372A in 2micron plasmids were transformed into ORC6-WT, ORC6-rxl, ORC6-ps or ORC6-rxl,ps
Satoshi Yoshida (112657) +3 more
core +1 more source
, 2022 Control of DNA replication is critical for progression of the cell cycle and genomic stability. Cyclin-dependent kinases (CDKs) coordinate numerous phosphorylation events to accomplish two biological tasks for all living organisms: DNA replication and ...
Philip, Jasmin
core
, 2012 The mutant allele of CDC6 that was identified in clinical isolate C and accompanied a small increase in echinocandin resistance, or a wild-type allele of CDC6 cloned from the early sensitive isolate A, was expressed on a plasmid under the control of its ...
Leah E. Cowen (108693) +9 more
core +1 more source
Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns
EMBO ReportsAcute protein knockdown is a powerful approach to dissecting protein function in dynamic cellular processes. We previously reported an improved auxin-inducible degron system, AID2, but recently noted that its ability to induce degradation of some ...
Yuki Hatoyama +5 more
doaj +1 more source
Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】 应用RNA干扰技术,靶向抑制舌癌细胞中Cdc6的表达,观察舌癌细胞增殖凋亡等改变,初步探讨下调Cdc6表达抑制舌癌细胞增殖的分子机制【方法】 实验分4组:空白对照组CON,阴性对照组NC,实验组KD1和KD2应用前期构建的Cdc6的慢病毒载体,转染舌癌CAL-27细胞,通过Real time RT-PCR和Western blot法检测Cdc6 mRNA及蛋白的表达;以MTT法测定活细胞数并绘制细胞生长曲线;利用流式细胞仪观察细胞凋亡【结果】 慢病毒载体转染CAL-27细胞后,Real ...
doaj
CDC6 is a possible biomarker for hepatocellular carcinoma.
International journal of clinical and experimental pathologyResearch has proven that the expression of CDC6 is tightly related to tumorigenesis and progression of various tumors. However, the effects of CDC6 in hepatocellular carcinoma remain uncertain. The main purpose of this research is to explore this relationship.We assessed the expression levels of CDC6 in a serious of cancers from GEPIA database.
De-Gang, Kong, Fu-Zhou, Yao
openaire +1 more source
Stranded short nascent strand sequencing reveals the topology of DNA replication origins in <i>Trypanosoma brucei</i>. [PDF]
ElifeStanojcic S +5 more
europepmc +1 more source
Integration of ploidy, Orc1/Cdc6 homolog function, and lysine acetylation with phosphate limitation and UV stress responses of Haloferax volcanii. [PDF]
ExtremophilesGal D +4 more
europepmc +1 more source