Results 101 to 110 of about 8,832 (194)

Using Mathematical Modeling of Tumor Metabolism to Predict the Magnitude, Composition, and Hypoxic Interactions of Microenvironment Acidosis

BioEssays, Volume 48, Issue 1, January 2026.
Mathematical model of a perfused cylindrical tumor predicts venous‐end extracellular [O2], pH, [CO2], and [HCO3−] in the case of either fermentative or respiratory metabolism, illustrating the relationship between hypoxia and acidosis and the chemical composition of acidosis in the tumor microenvironment. ABSTRACT In well‐perfused tissues, interstitial
Alzbeta Hulikova, Pawel Swietach
wiley   +1 more source

Cloning and characterization of theSaccharomyces cerevisiaeCDC6 gene

Nucleic Acids Research, 1988
The yeast cell division cycle gene CDC6 was isolated by complementation of a temperature-sensitive cdc6 mutant with a genomic library. The amino acid sequence of the 48 kDalton CDC6 gene product, as deduced from DNA sequence data, includes the three consensus peptide motifs involved in guanine nucleotide binding and GTPase activity, a target site for ...
J, Lisziewicz, A, Godany, D V, Agoston, H, Küntzel   +3 more
openaire   +3 more sources

Trypanosome Prereplication Machinery Contains a Single Functional Orc1/Cdc6 Protein, Which Is Typical of Archaea

, 2009
In unicellular eukaryotes, such as Saccharomyces cerevisiae, and in multicellular organisms, the replication origin is recognized by the heterohexamer origin recognition complex (ORC) containing six proteins, Orc1 to Orc6, while in members of the domain ...
SCHENKMAN, Sergio, PAES, Lisvane S., SILBER, Ariel M., Melo Godoy, Patricia Diogo de, GODOY, Patricia Diogo de Melo, MARTINS, Rafael Miyazawa, Cornejo, Alberto [UNIFESP], Martins, Rafael Miyazawa [UNIFESP], CORNEJO, Alberto, NOGUEIRA-JUNIOR, Luis Antonio, ELIAS, M. Carolina, Schenkman, Sergio [UNIFESP]   +11 more
core   +1 more source

Genome-wide Analysis Reveals Extensive Functional Interaction between DNA Replication Initiation and Transcription in the Genome of Trypanosoma brucei

Cell Reports, 2012
Identification of replication initiation sites, termed origins, is a crucial step in understanding genome transmission in any organism. Transcription of the Trypanosoma brucei genome is highly unusual, with each chromosome comprising a few discrete ...
Calvin Tiengwe, Lucio Marcello, Helen Farr, Nicholas Dickens, Steven Kelly, Michal Swiderski, Diane Vaughan, Keith Gull, J. David Barry, Stephen D. Bell, Richard McCulloch   +10 more
doaj   +1 more source

CDC6 mRNA Expression Is Associated with the Aggressiveness of Prostate Cancer

Journal of Korean Medical Science, 2018
Cell division cycle 6 (CDC6) is an essential regulator of DNA replication and plays important roles in the activation and maintenance of the checkpoint mechanisms in the cell cycle. CDC6 has been associated with oncogenic activities in human cancers; however, the clinical significance of CDC6 in prostate cancer (PCa) remains unclear.
Ye-Hwan Kim, Young Joon Byun, Won Tae Kim, Pildu Jeong, Chunri Yan, Ho Won Kang, Yong-June Kim, Sang-Cheol Lee, Sung-Kwon Moon, Yung-Hyun Choi, Seok Joong Yun, Wun-Jae Kim   +11 more
openaire   +2 more sources

H. utahensis primary contig and ORC/Cdc6 genes.

, 2013
Circular display of the largest contig of the H. utahensis genome sequence. The contig begins at the top and wraps clockwise. The red bars illustrate the location of ORC/Cdc6 orthologs. The ORC/Cdc6 gene numbered 3 lies near the origin of replication, at
Nick Carney (371732), Max Win (371749), Jay McNair (371743), Samantha Simpson (49727), Will DeLoache (371734), Matt Lotz (371741), Pallavi Penumetcha (371745), Peter Bakke (371731), Laurie J. Heyer (371750), A. Malcolm Campbell (56164), Mary Gearing (371736), Kjeld Ingvorsen (371739), Laura Voss (371747)   +12 more
core   +1 more source

Cdc6 Stability Is Regulated by the Huwe1 Ubiquitin Ligase after DNA Damage

, 2007
The Cdc6 protein is an essential component of pre-replication complexes (preRCs), which assemble at origins of DNA replication during the G1 phase of the cell cycle.
Cook, Jeanette Gowen, Zhong, Qing, Luce, K. Scott, Nevis, Kathleen R., Kow, Evelyn, Lu, Chiajung Karen, Hall, Jonathan R.   +6 more
core   +1 more source

The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activation [PDF]

, 2004
Before S phase, cells license replication origins for initiation by loading them with Mcm2-7 heterohexamers. This process is dependent on Cdc6, which is recruited to unlicensed origins.
Blow, J. Julian; id_orcid, Oehlmann, Maren, Alan J. Score, J. Julian Blow, Score, Alan J., Blow, J. Julian, Maren Oehlmann   +6 more
core   +1 more source

Karakterizacija monoklonskog protutijela protiv bjelančevine Cdc6

, 2016
Ciklus stanične diobe omogućuje povećanje mase i volumena stanice. Pogreške koje nastaju zbog poremećaja mehanizama koji reguliraju rast stanice dovode do patoloških stanja koja uključuju metaboličke poremećaje, upalne procese i zloćudnu preobrazbu ...
Barišić, Lalita
core  

SCF^{Cyclin F}-dependent degradation of CDC6 suppresses DNA re-replication [PDF]

, 2016
Maintenance of genome stability requires that DNA is replicated precisely once per cell cycle. This is believed to be achieved by limiting replication origin licensing and thereby restricting the firing of each replication origin to once per cell cycle ...
Komseli, Eirini-Stavroula, Sørensen, Claus Storgaard, Rappsilber, Juri, Gorgoulis, Vassilis, Komseli, Eirini Stavroula, Walter, David, Hoffmann, Saskia   +6 more
core   +1 more source