Results 91 to 100 of about 7,812 (168)
BMC Cancer, 2008 Background The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dysplasia and malignancy.
Tu Zheng +6 more
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BMC Genetics, 2007 Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes.
DasSarma Shiladitya +2 more
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Structure and Function of Cdc6/Cdc18 [PDF]
Molecular Cell, 2000 Liu, Jinyu +5 more
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Screening and verification of hub genes in esophageal squamous cell carcinoma by integrated analysis
Scientific ReportsEsophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors. However, the mechanisms underlying ESCC tumorigenesis have not been fully elucidated. Thus, we aimed to determine the key genes involved in ESCC tumorigenesis.
Hongqiang Wu +3 more
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Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns
EMBO ReportsAcute protein knockdown is a powerful approach to dissecting protein function in dynamic cellular processes. We previously reported an improved auxin-inducible degron system, AID2, but recently noted that its ability to induce degradation of some ...
Yuki Hatoyama +5 more
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Zhongshan Daxue xuebao. Yixue kexue ban, 2011 【目的】 应用RNA干扰技术,靶向抑制舌癌细胞中Cdc6的表达,观察舌癌细胞增殖凋亡等改变,初步探讨下调Cdc6表达抑制舌癌细胞增殖的分子机制【方法】 实验分4组:空白对照组CON,阴性对照组NC,实验组KD1和KD2应用前期构建的Cdc6的慢病毒载体,转染舌癌CAL-27细胞,通过Real time RT-PCR和Western blot法检测Cdc6 mRNA及蛋白的表达;以MTT法测定活细胞数并绘制细胞生长曲线;利用流式细胞仪观察细胞凋亡【结果】 慢病毒载体转染CAL-27细胞后,Real ...
doaj
CDC6 is a possible biomarker for hepatocellular carcinoma.
International journal of clinical and experimental pathologyResearch has proven that the expression of CDC6 is tightly related to tumorigenesis and progression of various tumors. However, the effects of CDC6 in hepatocellular carcinoma remain uncertain. The main purpose of this research is to explore this relationship.We assessed the expression levels of CDC6 in a serious of cancers from GEPIA database.
De-Gang, Kong, Fu-Zhou, Yao
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Stranded short nascent strand sequencing reveals the topology of DNA replication origins in <i>Trypanosoma brucei</i>. [PDF]
ElifeStanojcic S +5 more
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