Results 111 to 120 of about 8,832 (194)

SCFCyclin F-dependent degradation of CDC6 suppresses DNA re-replication

, 2016
Maintenance of genome stability requires that DNA is replicated precisely once per cell cycle. This is believed to be achieved by limiting replication origin licensing and thereby restricting the firing of each replication origin to once per cell cycle ...
Hoffmann, S., Gorgoulis, V., Walter, D., Sørensen, C.S., Rappsilber, J., Komseli, E.-S.   +5 more
core  

Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.

, 2015
Cdc6 encodes a key protein for DNA replication, responsible for the recruitment of the MCM helicase to replication origins during the G1 phase of the cell division cycle.
Sotiropoulou, Panagiota A, Búa, Sabela S, Blanpain, Cédric, Borlado, Luis R, Domínguez, Orlando, Malumbres, Marcos, Méndez, Juan, Sgarlata, Cecilia, Eguren, Manuel, Ortega, Sagrario   +9 more
core   +1 more source

mRNA expression of the DNA replication-initiation proteins in epithelial dysplasia and squamous cell carcinoma of the tongue

BMC Cancer, 2008
Background The tongue squamous cell carcinomas (SCCs) are characterized by high mitotic activity, and early detection is desirable. Overexpression of the DNA replication-initiation proteins has been associated with dysplasia and malignancy.
Tu Zheng, Lu Yong-jun, Li Hui-jun, Feng Chong-jin, Li Jian-na, Liao Gui-qing, Liang Chun   +6 more
doaj   +1 more source

Essential and non-essential DNA replication genes in the model halophilic Archaeon, Halobacterium sp. NRC-1

BMC Genetics, 2007
Background Information transfer systems in Archaea, including many components of the DNA replication machinery, are similar to those found in eukaryotes.
DasSarma Shiladitya, DasSarma Priya, Berquist Brian R   +2 more
doaj   +1 more source

The differential role of CDC6 in normal and cancer cells

, 2018
Homeodynamics (Lloyd, Aon et al. 2001) is a fundamental feature of single and multi-cellular organisms that is maintained by convenient cellular counteractions to a plethora of deleterious intrinsic and extrinsic signals.
Komseli, Eirini-Stavroula, Κομσέλη, Ειρήνη-Σταυρούλα   +1 more
core   +1 more source

Structure and Function of Cdc6/Cdc18 [PDF]

Molecular Cell, 2000
Liu, Jinyu, Smith, Cheryl L., DeRyckere, Deborah, DeAngelis, Kristen, Martin, G.Steven, Berger, James M.   +5 more
openaire   +1 more source

Spatio-temporal regulation of the human licensing factor Cdc6 in replication and mitosis

, 2016
To maintain genome stability, the thousands of replication origins of mammalian genomes must only initiate replication once per cell cycle. This is achieved by a strict temporal separation of ongoing replication in S phase, and the formation of pre ...
René M Linka (775681), Christian Mielke (723798), Faiza M Kalfalah (775679), Fritz Boege (723797), Elke Berg (723794), Morten O Christensen (775680), Wilhelm G Dirks (775682)   +6 more
core   +1 more source

Cdc6 amd replication competence in xenopus oocytes

, 2002
The early division cycles of an embryo following fertilization rely on the oocyte's ability to replicate DNA. During meiosis, oocytes temporarily lose their ability to replicate DNA.
Dallas, Elizabeth Whitmire
core  

Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle

, 2016
Cdc6 encodes a key protein for DNA replication, responsible for the recruitment of the MCM helicase to replication origins during the G1 phase of the cell division cycle.
Sagrario Ortega (201434), Juan Méndez (839467), Sabela Búa (839461), Orlando Domínguez (161125), Peggy Sotiropoulou (839462), Marcos Malumbres (266420), Manuel Eguren (839465), Cecilia Sgarlata (839463), Cedric Blanpain (839466), Luis R Borlado (839464)   +9 more
core   +1 more source

Screening and verification of hub genes in esophageal squamous cell carcinoma by integrated analysis

Scientific Reports
Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors. However, the mechanisms underlying ESCC tumorigenesis have not been fully elucidated. Thus, we aimed to determine the key genes involved in ESCC tumorigenesis.
Hongqiang Wu, Peiyao Zhu, Peng Shu, Shuguang Zhang   +3 more
doaj   +1 more source