Results 81 to 90 of about 8,832 (194)
Thermoplasma acidophilum Cdc6 protein stimulates MCM helicase activity by regulating its ATPase activity [PDF]
, 2008 The minichromosome maintenance (MCM) proteins are thought to function as the replicative helicases in archaea. In most archaeal species studied, the interaction between MCM and the initiator protein, Cdc6, inhibits helicase activity.
Haugland, Gyri Teien +5 more
core +1 more source
Genetic and physical mapping of DNA replication origins in Haloferax volcanii. [PDF]
PLoS Genetics, 2007 The halophilic archaeon Haloferax volcanii has a multireplicon genome, consisting of a main chromosome, three secondary chromosomes, and a plasmid. Genes for the initiator protein Cdc6/Orc1, which are commonly located adjacent to archaeal origins of DNA ...
Cédric Norais +5 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 2, Page 409-427, February 2026.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source
Identification of the sequence responsible for the nuclear localization of human Cdc6
FEBS Letters, 1999 The Cdc6 is the essential protein for the initiation of DNA replication. Cdc6 is localized in the G1 nucleus, and abnormal nuclear localization of this protein induces irregular initiation of DNA replication. We identified here that amino acids K57 and R58 in the human Cdc6 protein play an important role in the nuclear localization of the protein.
Takei, Yoshinori +2 more
openaire +2 more sources
BMC Cancer, 2023 Background Endocrine-resistant breast cancers have elevated expression of XBP1, where it drives endocrine resistance by controlling the expression of its target genes.
David Barua +5 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 2, Page 428-446, February 2026.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
A yeast GSK-3 kinase Mck1 promotes Cdc6 degradation to inhibit DNA re-replication.
PLoS Genetics, 2012 Cdc6p is an essential component of the pre-replicative complex (pre-RC), which binds to DNA replication origins to promote initiation of DNA replication. Only once per cell cycle does DNA replication take place.
Amy E Ikui +3 more
doaj +1 more source
Sparstolonin B inhibits pro-angiogenic functions and blocks cell cycle progression in endothelial cells. [PDF]
PLoS ONE, 2013 Sparstolonin B (SsnB) is a novel bioactive compound isolated from Sparganium stoloniferum, an herb historically used in Traditional Chinese Medicine as an anti-tumor agent. Angiogenesis, the process of new capillary formation from existing blood vessels,
Henry R Bateman +4 more
doaj +1 more source
Molecular Oncology, Volume 20, Issue 2, Page 260-281, February 2026.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Cell division cycle 6 is an independent prognostic biomarker in breast cancer
Cell division cycle 6 (CDC6) is a cell cycle protein involved in cell cycle control, DNA replication and cancer cell apoptosis. This study investigated the prognostic value of CDC6 in breast cancer (BC) utilising large well-characterised cohorts of early-
Alsaleem, Mansour +6 more
core +1 more source