Results 61 to 70 of about 8,832 (194)
Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer
Molecular & Cellular Oncology, 2017 A key step during onset of most cases of non-small cell lung cancer (NSCLC) is the loss of the tumor suppressor p16INK4a (best known as p16), commonly due to promoter hypermethylation.
C. Gamell +4 more
doaj +1 more source
High throughput sequencing revealed enhanced cell cycle signaling in SLE patients
Scientific Reports, 2023 The multi-system involvement and high heterogeneity of systemic lupus erythematosus (SLE) pose great challenges to its diagnosis and treatment. The purpose of the current study is to identify genes and pathways involved in the pathogenesis of SLE.
Mingyue Yang +6 more
doaj +1 more source
Advanced Science, EarlyView.This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang +16 more
wiley +1 more source
eLife, 2021 The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using an
Hsiang-Chen Chou +12 more
doaj +1 more source
The FEBS Journal, EarlyView.Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar +3 more
wiley +1 more source
Biology, 2023 Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika +3 more
doaj +1 more source
Circulating Tumor Cells in Multiple Myeloma: From Peripheral Clues to Central Insights
American Journal of Hematology, Volume 101, Issue 7, Page 1575-1588, July 2026.CTC offer a minimally invasive widow into systemic myeloma biology, overcoming the sampling bias of bone marrow biopsies. Their prognostic value at diagnosis, potential role in MRD monitoring, and ability to capture clonal evolution highlight them as actionable biomarkers for future precision medicine.
Benjamin Podvin +3 more
wiley +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.TRF enriches Ruminococcus, a bacterial genus producing SCFAs, and activates the epithelial HIF‐1α signaling pathway. This mechanism protects the colonic mucosa from inflammatory insults in colitis models. Mechanistically, gut lactate production during starvation and refeeding mediates H4K12la, which increases SLC9A3 expression and creates an acidic gut
Linwen Huang +17 more
wiley +1 more source
The 3 Rs of Cdc6: Recruitment, Regulation, and Replication [PDF]
Current Biology, 2002 What is it? The cell division cycle genes CDC6 and CDC18 encode budding and fission yeast orthologs identified in a series of elegant screens for regulators of cell cycle progression performed independently by Leland Hartwell and Paul Nurse in the 1970s.
openaire +2 more sources
BMI1 interacts with CDC6 and is required for CDC6 repressing function.
, 2013 A) Western Blot analysis of Myc-CDC6 Wild type and Bmi1 mutant transduced cells. The antibodies used are indicated. GAPDH antibody is used as a loading control. Ab) quantitative PCR experiment showing p16INK4a and p19ARF expression in Myc-CDC6 transduced
Lionel Chasson (118754) +5 more
core +1 more source