Results 41 to 50 of about 8,832 (194)

DNA replication licensing in somatic and germ cells [PDF]

, 2004
The DNA replication (or origin) licensing system ensures precise duplication of the genome in each cell cycle and is a powerful regulator of cell proliferation in metazoa.
Williams, C, Jung, Hyo-Il, Obermann, EC, Ellen C. Obermann, Kai Stoeber, Loddo, Marco, Kathryn Leigh Eward, Marco Loddo, Shreeram, S, Williams, GH, Obermann, Ellen C, Hyo-Il Jung, Williams, Craig, J. Julian Blow, Gareth H. Williams, Eward, Kathryn Leigh, Fanshawe, Thomas, Jung, HI, Shreeram, S., Prevost, Toby; id_orcid, Blow, J. Julian; id_orcid, A. Toby Prevost, Loddo, M, Williams, Gareth H., Thomas Fanshawe, Fanshawe, T, Obermann, Ellen C., Eward, KL, Williams, Gareth H, Jung, H-I, S. Shreeram, Blow, J Julian, Prevost, A. Toby, Stoeber, K, Stoeber, Kai, Blow, J. Julian, Prevost, AT, Blow, JJ, Craig Williams   +38 more
core   +1 more source

Regulation of Minichromosome Maintenance Helicase Activity by Cdc6 [PDF]

Journal of Biological Chemistry, 2003
Genetic studies, together with amino acid and structural similarities to the clamp loaders of DNA polymerase sliding clamps, have suggested that the Cdc6 protein may function as a loader for the eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex.
Jae-Ho, Shin, Beatrice, Grabowski, Rajesh, Kasiviswanathan, Stephen D, Bell, Zvi, Kelman   +4 more
openaire   +2 more sources

Cryo-EM structure of a helicase loading intermediate containing ORC-Cdc6-Cdt1-MCM2-7 bound to DNA [PDF]

, 2013
26.03.14 KB.
Cecile Evrin, Kawakami, H, Li, H, Riera, A, Alejandra Fernández-Cid, Jingchuan Sun, Riera, A., Stillman, B, Stillman, B., Stefan A Samel, Christian Speck, Hironori Kawakami, Speck, C., Samel, S. A., Fernandez-Cid, A., Samel, AS, Speck, C, Sun, J., Sun, J, Fernandez-Cid, A, Huilin Li, Evrin, C., Kawakami, H., Evrin, C, Li, H., Alberto Riera, Bruce Stillman   +26 more
core   +1 more source

A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer

Journal of Experimental & Clinical Cancer Research, 2023
Background Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen ...
Ioanna Mourkioti, Aikaterini Polyzou, Dimitris Veroutis, George Theocharous, Nefeli Lagopati, Emanuela Gentile, Vasiliki Stravokefalou, Dimitris-Foivos Thanos, Sophia Havaki, Dimitris Kletsas, Theocharis Panaretakis, Christopher J. Logothetis, Dimitris Stellas, Russell Petty, Giovanni Blandino, Angelos Papaspyropoulos, Vassilis G. Gorgoulis   +16 more
doaj   +1 more source

Linking mitosis with S-phase: Cdc6 at play [PDF]

Cell Cycle, 2008
In order to maintain genomic stability, cells must coordinate DNA replication such that every origin of replication fires once and only once per cell cycle. In addition, the order of replication and mitosis must be strictly controlled. To accomplish regulated origin firing, multicomponent pre-replicative complexes (pre-RCs) are assembled at origins of ...
Susanna, Boronat, Judith L, Campbell
openaire   +2 more sources

Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.

PLoS Genetics, 2021
DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs.
Amy E Ikui, Noriko Ueki, Kresti Pecani, Frederick R Cross   +3 more
doaj   +1 more source

The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin [PDF]

Current Biology, 1999
Replication licensing factor (RLF) is an essential initiation factor that can prevent re-replication of DNA in a single cell cycle [1] [2]. It is required for the initiation of DNA replication, binds to chromatin early in the cell cycle, is removed from chromatin as DNA replicates and is unable to re-bind replicated chromatin until the following ...
Tada, Shusuke, Chong, James P. J., Mahbubani, Hiro M., Blow, J. Julian   +3 more
openaire   +3 more sources

The Cdc6 Protein Is Ubiquitinated in Vivo for Proteolysis in Saccharomyces cerevisiae [PDF]

Journal of Biological Chemistry, 1999
The Saccharomyces cerevisiae Cdc6 protein is necessary for the formation of pre-replicative complexes that are required for firing DNA replication at origins at the beginning of S phase. Cdc6p protein levels oscillate during the cell cycle. In a normal cell cycle the presence of this protein is restricted to G1, partly because the CDC6 gene is ...
Sánchez, Mar, Calzada, Arturo, Bueno, Avelino   +2 more
openaire   +3 more sources

In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias

Cell Reports, 2017
Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA ...
Sergio Muñoz, Sabela Búa, Sara Rodríguez-Acebes, Diego Megías, Sagrario Ortega, Alba de Martino, Juan Méndez   +6 more
doaj   +1 more source

Cdc6 is required for meiotic spindle assembly in Xenopus oocytes [PDF]

Cell Cycle, 2012
During the maturation of Xenopus oocytes, Cdc6 expression is necessary to establish replication competence to support early embryonic DNA replication. However, Cdc6 is expressed before the completion of MI, at a time when its function as a replication factor is not required, suggesting additional roles for Cdc6 in meiosis.
Yadushyla, Narasimhachar, Daniel R, Webster, David L, Gard, Martine, Coué   +3 more
openaire   +2 more sources