Results 41 to 50 of about 7,812 (168)
Scientific Reports, 2023 Circular RNAs (circRNA) are known to function as competing endogenous RNA (ceRNA) in various cancers by regulating microRNAs (miRNA). However, in colorectal cancer (CRC), the precise pathological role of circ000240/miRNA/mRNA remains indeterminate.
Ghanbar Mahmoodi Chalbatani +10 more
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Cdc6 licenses tumor growth [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Unlike control cells (left), cells that overexpress Cdc6 (right) lose E-cadherin (green) from the plasma membrane. Aprotein that permits cells to replicate their DNA also shuts down a tumor suppressor gene, [Sideridou et al.][2] report.
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Multiple Mechanisms Regulate Subcellular Localization of Human CDC6 [PDF]
Journal of Biological Chemistry, 2001 CDC6 is a protein essential for DNA replication, the expression and abundance of which are cell cycle-regulated in Saccharomyces cerevisiae. We have demonstrated previously that the subcellular localization of the human CDC6 homolog, HsCDC6, is cell cycle-dependent: nuclear during G(1) phase and cytoplasmic during S phase.
L M, Delmolino, P, Saha, A, Dutta
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BMC Research Notes, 2019 Objective Sulfodiicoccus acidiphilus HS-1T is the type species of the genus Sulfodiicoccus, a thermoacidophilic archaeon belonging to the order Sulfolobales (class Thermoprotei; phylum Crenarchaeota). While S.
Hiroyuki D. Sakai, Norio Kurosawa
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The FEBS Journal, EarlyView.Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar +3 more
wiley +1 more source
Analysis of Cdc6 function in the assembly of mammalian prereplication complexes [PDF]
Proceedings of the National Academy of Sciences, 2002 Eukaryotic DNA replication requires the previous formation of a prereplication complex containing the ATPase Cdc6 and the minichromosome maintenance (Mcm) complex. Although considerable insight has been gained from in vitro studies and yeast genetics, the functional analysis of replication ...
Jeanette Gowen, Cook +6 more
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Exploring Bioinformatics Tools to Analyze the Role of CDC6 in the Progression of Polycystic Ovary Syndrome to Endometrial Cancer by Promoting Immune Infiltration [PDF]
International Journal of Molecular SciencesYizhou Zou, Yao Li, Zou Yizhou
exaly +2 more sources
Estrogen-induced upregulation and 3′-UTR shortening of CDC6 [PDF]
Nucleic Acids Research, 2012 3'-Untranslated region (UTR) shortening of mRNAs via alternative polyadenylation (APA) has important ramifications for gene expression. By using proximal APA sites and switching to shorter 3'-UTRs, proliferating cells avoid miRNA-mediated repression. Such APA and 3'-UTR shortening events may explain the basis of some of the proto-oncogene activation ...
Begum H. Akman +2 more
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eLife, 2021 The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using an
Hsiang-Chen Chou +12 more
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Ploidy‐dependent modulation of DNA replication kinetics in Xenopus
The FEBS Journal, EarlyView.Using an interspecies replication system with Xenopus frog species of different ploidy levels, we investigated how DNA replication adapts to polyploidization. While replication was slower in tetraploid than in diploid nuclei, dodecaploid nuclei unexpectedly replicated faster than tetraploid nuclei. Our findings show that increasing genome size does not
Hemalatha Narassimprakash +4 more
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