Results 31 to 40 of about 7,812 (168)
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer
Journal of Experimental & Clinical Cancer Research, 2023 Background Prostate cancer is a major cause of cancer morbidity and mortality in men worldwide. Androgen deprivation therapy (ADT) has proven effective in early-stage androgen-sensitive disease, but prostate cancer gradually develops into an androgen ...
Ioanna Mourkioti +16 more
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Control of pre-replicative complex during the division cycle in Chlamydomonas reinhardtii.
PLoS Genetics, 2021 DNA replication is fundamental to all living organisms. In yeast and animals, it is triggered by an assembly of pre-replicative complex including ORC, CDC6 and MCMs.
Amy E Ikui +3 more
doaj +1 more source
Linking mitosis with S-phase: Cdc6 at play [PDF]
Cell Cycle, 2008 In order to maintain genomic stability, cells must coordinate DNA replication such that every origin of replication fires once and only once per cell cycle. In addition, the order of replication and mitosis must be strictly controlled. To accomplish regulated origin firing, multicomponent pre-replicative complexes (pre-RCs) are assembled at origins of ...
Susanna, Boronat, Judith L, Campbell
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Expression and Stability of Arabidopsis CDC6 Are Associated with Endoreplication [PDF]
The Plant Cell, 2001 Studies on the CDC6 protein, which is crucial to the control of DNA replication in yeast and animal cells, are lacking in plants. We have isolated an Arabidopsis cDNA encoding the AtCDC6 protein and studied its possible connection to the occurrence of developmentally regulated endoreplication cycles.
M M, Castellano +4 more
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Cell Reports, 2017 Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 expression is increased during prostate cancer (PCa) progression and positively correlates with AR in PCa ...
Styliani Karanika +18 more
doaj +1 more source
The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin [PDF]
Current Biology, 1999 Replication licensing factor (RLF) is an essential initiation factor that can prevent re-replication of DNA in a single cell cycle [1] [2]. It is required for the initiation of DNA replication, binds to chromatin early in the cell cycle, is removed from chromatin as DNA replicates and is unable to re-bind replicated chromatin until the following ...
Tada, Shusuke +3 more
openaire +3 more sources
In Vivo DNA Re-replication Elicits Lethal Tissue Dysplasias
Cell Reports, 2017 Summary: Mammalian DNA replication origins are “licensed” by the loading of DNA helicases, a reaction that is mediated by CDC6 and CDT1 proteins. After initiation of DNA synthesis, CDC6 and CDT1 are inhibited to prevent origin reactivation and DNA ...
Sergio Muñoz +6 more
doaj +1 more source
The Cdc6 Protein Is Ubiquitinated in Vivo for Proteolysis in Saccharomyces cerevisiae [PDF]
Journal of Biological Chemistry, 1999 The Saccharomyces cerevisiae Cdc6 protein is necessary for the formation of pre-replicative complexes that are required for firing DNA replication at origins at the beginning of S phase. Cdc6p protein levels oscillate during the cell cycle. In a normal cell cycle the presence of this protein is restricted to G1, partly because the CDC6 gene is ...
Sánchez, Mar +2 more
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Cdc6 is required for meiotic spindle assembly in Xenopus oocytes [PDF]
Cell Cycle, 2012 During the maturation of Xenopus oocytes, Cdc6 expression is necessary to establish replication competence to support early embryonic DNA replication. However, Cdc6 is expressed before the completion of MI, at a time when its function as a replication factor is not required, suggesting additional roles for Cdc6 in meiosis.
Yadushyla, Narasimhachar +3 more
openaire +2 more sources
Archives of Medical Science, 2019 Introduction Gastric cancer is one of the most common cancers of the digestive system and is associated with high morbidity and mortality. The aim of this study was to investigate whether miR-26b is involved in the proliferation and resistance to ...
Bochao Zhao +4 more
doaj +1 more source