Results 31 to 40 of about 8,832 (194)
Cdc6: Skin in the carcinogenesis game [PDF]
Cell Cycle, 2016 Initiation of DNA duplication occurs through the assembly of multiple protein complexes onto replication origins (ORIs).
Leonardo K, Teixeira, Steven I, Reed
openaire +2 more sources
Role of TOP2A and CDC6 in liver cancer
Medicine, 2023 Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high mortality worldwide, which is characterized by aggressive growth and metastasis. However, the relationship between TOP2A and CDC6 and HCC remains unclear. GSE121248 and GSE101728 profiles for liver cancer were downloaded from the gene expression omnibus database ...
Jia, Wei, Liu, Xiang, Zhang, Zhilei
openaire +2 more sources
Veterinary and Comparative Oncology, 2021 AbstractCirculating nucleic acids and extracellular vesicles (EV) represent novel biomarkers to diagnose cancer. The non‐invasive nature of these so‐called liquid biopsies provides an attractive alternative to tissue biopsy‐based cancer diagnostics. This study aimed to investigate if circulating cell cycle‐related E2F target transcripts can be used to ...
Anneloes Andriessen +10 more
openaire +5 more sources
Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells. [PDF]
PLoS ONE, 2016 Paclitaxel (PTX) is an antimitotic drug that possesses potent anticancer activity, but its therapeutic potential in the clinic has been hindered by drug resistance.
Yue He +5 more
doaj +1 more source
Cdc6 requires anchorage for its expression [PDF]
Oncogene, 2002 Fibroblasts need anchorage to extracellular matrix to transit from G1 to S phase, but no longer after oncogenic transformation. Here we report that Cdc6 protein essential for the activation of replication origins requires anchorage or oncogenic stimulation for its execution.
Shigeki, Jinno +3 more
openaire +2 more sources
Caspase-3-mediated Cleavage of Cdc6 Induces Nuclear Localization of p49-truncated Cdc6 and Apoptosis [PDF]
Molecular Biology of the Cell, 2003 We show that Cdc6, an essential initiation factor for DNA replication, undergoes caspase-3–mediated cleavage in the early stages of apoptosis in HeLa cells and SK-HEP-1 cells induced by etoposide, paclitaxel, ginsenoside Rh2, or tumor necrosis factor-related apoptosis-inducing ligand.
Hyungshin, Yim +4 more
openaire +2 more sources
LncRNA NORAD engages in psoriasis by binding to miR-26a to regulate keratinocyte proliferation
Autoimmunity, 2021 Background Psoriasis is a chronic, inflammatory skin disease. It was reported that lncRNA Non-coding RNA-activated by DNA damage (NORAD) has potential regulatory effects on skin diseases.
Shuiqi Li +7 more
doaj +1 more source
The Journal of Cell Biology, 2006 The replication initiation factor Cdc6 is cleaved during apoptosis, and expression of a cleavage product is sufficient to induce apoptosis in otherwise unstressed cells. On page 77, Yim et al. report that the cleavage products can act as dominant-negative inhibitors of replication and amplify pro-death signals.
openaire +1 more source
Expression and Stability of Arabidopsis CDC6 Are Associated with Endoreplication [PDF]
The Plant Cell, 2001 Studies on the CDC6 protein, which is crucial to the control of DNA replication in yeast and animal cells, are lacking in plants. We have isolated an Arabidopsis cDNA encoding the AtCDC6 protein and studied its possible connection to the occurrence of developmentally regulated endoreplication cycles.
M M, Castellano +4 more
openaire +4 more sources
Autophosphorylation of Archaeal Cdc6 Homologues Is Regulated by DNA [PDF]
Journal of Bacteriology, 2001 ABSTRACTThe initiator protein Cdc6 (Cdc18 in fission yeast) plays an essential role in the initiation of eukaryotic DNA replication. In yeast the protein is expressed before initiation of DNA replication and is thought to be essential for loading of the helicase onto origin DNA.
B, Grabowski, Z, Kelman
openaire +2 more sources