Results 21 to 30 of about 7,812 (168)
Role of TOP2A and CDC6 in liver cancer
Medicine, 2023 Hepatocellular carcinoma (HCC) is one of the most common malignant tumors with high mortality worldwide, which is characterized by aggressive growth and metastasis. However, the relationship between TOP2A and CDC6 and HCC remains unclear. GSE121248 and GSE101728 profiles for liver cancer were downloaded from the gene expression omnibus database ...
Jia, Wei, Liu, Xiang, Zhang, Zhilei
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LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway
Mediators of Inflammation, 2023 Background. Prostate cancer (PCa) harms the male reproductive system, and lncRNA may play an important role in it. Here, we report that the LINC01088/microRNA- (miRNA/miR-) 22/cell division cycle 6 (CDC6) axis regulated through the phosphatidylinositide ...
Jianwei Li +5 more
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Cdc6 requires anchorage for its expression [PDF]
Oncogene, 2002 Fibroblasts need anchorage to extracellular matrix to transit from G1 to S phase, but no longer after oncogenic transformation. Here we report that Cdc6 protein essential for the activation of replication origins requires anchorage or oncogenic stimulation for its execution.
Shigeki, Jinno +3 more
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Cell Division Cycle 6 Promotes Mitotic Slippage and Contributes to Drug Resistance in Paclitaxel-Treated Cancer Cells. [PDF]
PLoS ONE, 2016 Paclitaxel (PTX) is an antimitotic drug that possesses potent anticancer activity, but its therapeutic potential in the clinic has been hindered by drug resistance.
Yue He +5 more
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Caspase-3-mediated Cleavage of Cdc6 Induces Nuclear Localization of p49-truncated Cdc6 and Apoptosis [PDF]
Molecular Biology of the Cell, 2003 We show that Cdc6, an essential initiation factor for DNA replication, undergoes caspase-3–mediated cleavage in the early stages of apoptosis in HeLa cells and SK-HEP-1 cells induced by etoposide, paclitaxel, ginsenoside Rh2, or tumor necrosis factor-related apoptosis-inducing ligand.
Hyungshin, Yim +4 more
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Veterinary and Comparative Oncology, 2021 AbstractCirculating nucleic acids and extracellular vesicles (EV) represent novel biomarkers to diagnose cancer. The non‐invasive nature of these so‐called liquid biopsies provides an attractive alternative to tissue biopsy‐based cancer diagnostics. This study aimed to investigate if circulating cell cycle‐related E2F target transcripts can be used to ...
Anneloes Andriessen +10 more
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The Journal of Cell Biology, 2006 The replication initiation factor Cdc6 is cleaved during apoptosis, and expression of a cleavage product is sufficient to induce apoptosis in otherwise unstressed cells. On page 77, Yim et al. report that the cleavage products can act as dominant-negative inhibitors of replication and amplify pro-death signals.
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Autophosphorylation of Archaeal Cdc6 Homologues Is Regulated by DNA [PDF]
Journal of Bacteriology, 2001 ABSTRACTThe initiator protein Cdc6 (Cdc18 in fission yeast) plays an essential role in the initiation of eukaryotic DNA replication. In yeast the protein is expressed before initiation of DNA replication and is thought to be essential for loading of the helicase onto origin DNA.
B, Grabowski, Z, Kelman
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LncRNA NORAD engages in psoriasis by binding to miR-26a to regulate keratinocyte proliferation
Autoimmunity, 2021 Background Psoriasis is a chronic, inflammatory skin disease. It was reported that lncRNA Non-coding RNA-activated by DNA damage (NORAD) has potential regulatory effects on skin diseases.
Shuiqi Li +7 more
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Regulation of Minichromosome Maintenance Helicase Activity by Cdc6 [PDF]
Journal of Biological Chemistry, 2003 Genetic studies, together with amino acid and structural similarities to the clamp loaders of DNA polymerase sliding clamps, have suggested that the Cdc6 protein may function as a loader for the eukaryotic replicative helicase, the minichromosome maintenance (MCM) complex.
Jae-Ho, Shin +4 more
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