Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC [PDF]
Translational OncologyBackground: Cell division cycle 6 (CDC6) is a member of the AAA+ ATPase family and has chaperone-like activity. Many studies have shown that CDC6 plays an important role in cancer development and progression.
Zhong Zeng, Chenxuan Li
exaly +4 more sources
CDC6/THBS1 accelerates pancreatic cancer progression via AKT-mediated glycolytic reprogramming [PDF]
Cell Death and DiseasePancreatic cancer remains one of the most aggressive malignancies, characterized by early metastatic spread and intrinsic resistance to chemotherapy, which ultimately results in poor treatment outcomes.
Mengqiu Yin +5 more
doaj +2 more sources
PRDM1 restricts bladder cancer progression and enhances chemosensitivity by suppressing OTUD6A-mediated deubiquitination of CDC6 [PDF]
Cell Death and DiseasePR domain zinc finger protein 1 (PRDM1) functions as a critical transcriptional repressor. The role of PRDM1 in various tumors is controversial, and its specific mechanism in bladder cancer (BCa) remains unclear.
Jianfeng Cui +9 more
doaj +2 more sources
CDC6 as a pan-cancer immunological and prognostic biomarker and its role in suppressing melanoma malignancy [PDF]
BMC CancerBackground Cell division cycle 6 (CDC6) is a key licensing factor for DNA replication in the G1 and S phases. Besides initiating replication, CDC6 also helps establish and maintain the S-M checkpoint, ensuring genomic stability.
Lijun Mo +12 more
doaj +2 more sources
Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [PDF]
Signal Transduction and Targeted TherapyThe widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance,
Yue Liu +9 more
doaj +2 more sources
Therapeutic efficacy monitoring in canine lymphoma patients via quantifying CDC6 plasma levels [PDF]
BMC Veterinary ResearchBackground Liquid biopsies have gained increasing recognition as minimally invasive ways to monitor treatment response in cancer patients. They carry circulating DNA, RNA, and proteins in and outside of extracellular vesicles (EVs).
Anne Seijger +11 more
doaj +2 more sources
Putrescine functions as a metabolic checkpoint in replication stress-induced senescence [PDF]
Cellular and Molecular Life SciencesCellular senescence represents a fundamental biological response to replication stress and other genotoxic insults, acting as both a barrier to malignant transformation and a driver of age-related tissue dysfunction.
Theodora Vasilogiannakopoulou +8 more
doaj +2 more sources
RPL28 mediates sorafenib resistance in hepatocellular carcinoma by downregulating CDC6 expression [PDF]
Frontiers in OncologyAimSorafenib is a milestone targeted therapy for advanced hepatocellular carcinoma (HCC), yet resistance to this agent severely limits its clinical efficacy. The molecular mechanisms underlying sorafenib resistance are incompletely understood.
Yi Shi +5 more
doaj +2 more sources
CDC6 as early biomarker for myocardial infarction with acute cellular senescence and repair mechanisms [PDF]
Scientific ReportsWe aimed to the exploration of genes related to the cell cycle and the mechanisms of cardiac cell repair and senescence post-MI. The sequencing dataset of myocardial infarction in mice (GSE161427) was downloaded from the Gene Expression Omnibus (GEO ...
Yun Wen +5 more
doaj +2 more sources
Unidirectional MCM translocation away from ORC drives origin licensing [PDF]
Nature CommunicationsThe MCM motor of the eukaryotic replicative helicase is loaded as a double hexamer onto DNA by the Origin Recognition Complex (ORC), Cdc6, and Cdt1. ATP binding supports formation of the ORC-Cdc6-Cdt1-MCM (OCCM) helicase-recruitment complex where ORC ...
Agata Butryn +2 more
doaj +2 more sources