Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC [PDF]
Translational OncologyBackground: Cell division cycle 6 (CDC6) is a member of the AAA+ ATPase family and has chaperone-like activity. Many studies have shown that CDC6 plays an important role in cancer development and progression.
Chenxuan Li, Zhong Zeng, Hanfei Huang
exaly +5 more sources
Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication [PDF]
eLife, 2015 To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
FuJung Chang +6 more
doaj +7 more sources
The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6 [PDF]
Nature Communications, 2021 Eukaryotic DNA replication is mediated by many proteins which are tightly regulated for an efficient firing of replication at each cell cycle. Here the authors report a cryo-EM structure of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA revealing ...
Xiang Feng +5 more
doaj +6 more sources
The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]
Scientific Reports, 2017 DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Ravikiran Mahadevappa +8 more
doaj +7 more sources
Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation
International Journal of Cancer, 2020 Cdc6 is a key replication licencing factor with a pivotal role in regulating the process of DNA replication, rendering it an important investigatory focus in tumourigenesis. Indeed, Cdc6 overexpression has been found to be a feature in certain tumours and has been associated as an early event in malignancies.
Nicholas Lim, Paul A Townsend
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Increased CDC6 Expression Associates With Poor Prognosis in Patients With Clear Cell Renal Cell Carcinoma [PDF]
Frontiers in Oncology, 2021 BackgroundCDC6 (Cell division control protein 6), located at chromosome 17q21.3, plays an important role in the early stage of DNA replication and has unique functions in various malignant tumors.
Yicong Yao +4 more
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CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma
Molecular Cancer, 2022 Background Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it’s role in glioma, which is ranked as one of the common primary malignant tumor in the central nervous ...
Feng Wang +43 more
doaj +3 more sources
Cell Reports, 2017 Cell division cycle 6 (CDC6), an androgen receptor (AR) target gene, is implicated in regulating DNA replication and checkpoint mechanisms. CDC6 expression is increased during prostate cancer (PCa) progression and positively correlates with AR in PCa ...
Styliani Karanika +2 more
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Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance
Molecular CancerBackground CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 ...
Jianfeng Cui +20 more
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LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis
Cell Death and Disease, 2022 Long non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro and in vivo.
Juze Yang +13 more
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