Results 11 to 20 of about 7,812 (168)

Cdc6 ATPase activity disengages Cdc6 from the pre-replicative complex to promote DNA replication

eLife, 2015
To initiate DNA replication, cells first load an MCM helicase double hexamer at origins in a reaction requiring ORC, Cdc6, and Cdt1, also called pre-replicative complex (pre-RC) assembly.
FuJung Chang, Alberto Riera, Cecile Evrin, Jingchuan Sun, Huilin Li, Christian Speck, Michael Weinreich   +6 more
doaj   +4 more sources

The structure of ORC–Cdc6 on an origin DNA reveals the mechanism of ORC activation by the replication initiator Cdc6 [PDF]

Nature Communications, 2021
Eukaryotic DNA replication is mediated by many proteins which are tightly regulated for an efficient firing of replication at each cell cycle. Here the authors report a cryo-EM structure of the yeast ORC–Cdc6 bound to an 85-bp ARS1 origin DNA revealing ...
Xiang Feng, Yasunori Noguchi, Marta Barbon, Bruce Stillman, Christian Speck, Huilin Li   +5 more
doaj   +4 more sources

CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma

Molecular Cancer, 2022
Background Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. However, it’s role in glioma, which is ranked as one of the common primary malignant tumor in the central nervous ...
Feng Wang, Fen Zhao, Li Zhang, Lai Xiong, Qing Mao, Yanhui Liu, Xiaoguang Qiu, Xiang Wang, Lin Shui, Xi Chen, Kexing Ren, Pixian Shui, Qiongwen Zhang, Yifei Deng, Weimin Li, Xiaoqi Xie, Dengbin Wu, Tao Li, Jinyi Lang, Lei Liu, Huaying Chen, Jianguo Xu, Sen Bai, Zhiping Li, Qiang Yue, Ni Chen, Bingwen Zhou, Cheng Yi, Yuquan Wei, Yuchuan Fu, Yong Luo, Qiheng Gou, Lunxu Liu, Yuanzhao Liu, Jingbo Kang, Junjie Wang, Dongcun Jing, Fuquan Zhang, Xiaoyan Yang, Xianfeng Li, Tao Jiang, Zongcun Zhang, Yizhi Zhou, Junlin Yi   +43 more
doaj   +3 more sources

The prognostic significance of Cdc6 and Cdt1 in breast cancer [PDF]

Scientific Reports, 2017
DNA replication is a critical step in cell proliferation. Overexpression of MCM2-7 genes correlated with poor prognosis in breast cancer patients. However, the roles of Cdc6 and Cdt1, which work with MCMs to regulate DNA replication, in breast cancers ...
Ravikiran Mahadevappa, Henrique Neves, Shun Ming Yuen, Yuchen Bai, Cian M. McCrudden, Hiu Fung Yuen, Qing Wen, Shu Dong Zhang, Hang Fai Kwok   +8 more
doaj   +5 more sources

LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis

Cell Death and Disease, 2022
Long non-coding RNAs (lncRNAs) is known to play vital roles in modulating tumorigenesis. We previously reported that LCAT1, a novel lncRNA, promotes the growth and metastasis of lung cancer cells both in vitro and in vivo.
Juze Yang, Xinyi Qian, Qiongzi Qiu, Lingling Xu, Meidie Pan, Jia Li, Jiayi Ren, Bingjian Lu, Ting Qiu, Enguo Chen, Kejing Ying, Honghe Zhang, Yan Lu, Pengyuan Liu   +13 more
doaj   +3 more sources

Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance

Molecular Cancer
Background CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 ...
Jianfeng Cui, Xiaochen Liu, Qinghong Shang, Shuna Sun, Shouzhen Chen, Jianping Dong, Yaofeng Zhu, Lei Liu, Yangyang Xia, Yong Wang, Lu Xiang, Bowen Fan, Jiafeng Zhan, Yadi Zhou, Pengxiang Chen, Renchang Zhao, Xiaofei Liu, Nianzeng Xing, Dalei Wu, Benkang Shi, Yongxin Zou   +20 more
doaj   +3 more sources

Increased CDC6 Expression Associates With Poor Prognosis in Patients With Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundCDC6 (Cell division control protein 6), located at chromosome 17q21.3, plays an important role in the early stage of DNA replication and has unique functions in various malignant tumors.
Yicong Yao, Yicong Yao, Yi Wang, Denglong Wu, Baoying Hu   +4 more
doaj   +1 more source

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

eLife, 2022
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S
Jasmin Philip, Mihkel Örd, Andriele Silva, Shaneen Singh, John FX Diffley, Dirk Remus, Mart Loog, Amy E Ikui   +7 more
doaj   +1 more source

CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphoma

BMC Cancer, 2023
Background Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative complexes at origins of replication. The role of CDC6 in the pathogenesis of in diffuse larger B-cell lymphoma (DLBCL) remains unknown.
Mingfang Shen, Yunfeng Zhang, Lun Tang, Qinyan Fu, Jiawei Zhang, Yang Xu, Hui Zeng, Yuan Li   +7 more
doaj   +1 more source

Cdc6: Skin in the carcinogenesis game [PDF]

Cell Cycle, 2016
Initiation of DNA duplication occurs through the assembly of multiple protein complexes onto replication origins (ORIs).
Leonardo K, Teixeira, Steven I, Reed
openaire   +2 more sources