Results 11 to 20 of about 8,832 (194)

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae

eLife, 2022
Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In Saccharomyces cerevisiae, Cdk1 phosphorylates Cdc6-T7 to recruit Cks1, the Cdk1 phospho-adaptor in S
Jasmin Philip, Mihkel Örd, Andriele Silva, Shaneen Singh, John FX Diffley, Dirk Remus, Mart Loog, Amy E Ikui   +7 more
doaj   +2 more sources

CDC6/THBS1 accelerates pancreatic cancer progression via AKT-mediated glycolytic reprogramming [PDF]

Cell Death and Disease
Pancreatic cancer remains one of the most aggressive malignancies, characterized by early metastatic spread and intrinsic resistance to chemotherapy, which ultimately results in poor treatment outcomes.
Mengqiu Yin, Xi Chen, Ziyu Liu, Chongyu Wang, Tianyu Chen, Jinhui Zhu   +5 more
doaj   +2 more sources

LINC01088/miR-22/CDC6 Axis Regulates Prostate Cancer Progression by Activating the PI3K/AKT Pathway

Mediators of Inflammation, 2023
Background. Prostate cancer (PCa) harms the male reproductive system, and lncRNA may play an important role in it. Here, we report that the LINC01088/microRNA- (miRNA/miR-) 22/cell division cycle 6 (CDC6) axis regulated through the phosphatidylinositide ...
Jianwei Li, Xinghua Huang, Haodong Chen, Caifu Gu, Binyu Ni, Jianhua Zhou   +5 more
doaj   +2 more sources

Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. [PDF]

PLoS ONE, 2012
DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe, Lucio Marcello, Helen Farr, Catarina Gadelha, Richard Burchmore, J David Barry, Stephen D Bell, Richard McCulloch   +7 more
doaj   +2 more sources

PRDM1 restricts bladder cancer progression and enhances chemosensitivity by suppressing OTUD6A-mediated deubiquitination of CDC6 [PDF]

Cell Death and Disease
PR domain zinc finger protein 1 (PRDM1) functions as a critical transcriptional repressor. The role of PRDM1 in various tumors is controversial, and its specific mechanism in bladder cancer (BCa) remains unclear.
Jianfeng Cui, Shouzhen Chen, Xiaochen Liu, Xuewen Jiang, Guangzhou Cheng, Zhifeng Liu, Hui Zhao, Yaofeng Zhu, Benkang Shi, Yongxin Zou   +9 more
doaj   +2 more sources

CDC6 Inhibits CDK1 Activity in MII-Arrested Oocyte Cell-Free Extract [PDF]

Int J Mol Sci
The control of cyclin-dependent kinase 1 (CDK1) kinase activity is crucial for cell cycle progression. Cell division cycle 6 (CDC6) inhibits this activity in embryonic mitoses, and thus regulates the timing of cell division progression.
Piprek, Rafal, P., Klaudia Porębska, Jean-Pierre Tassan, Piprek, Rafał, Kubiak, Jacek Z., Louis Dillac, Dillac, Louis, Tassan, Jean-Pierre, Porębska, Klaudia, Malgorzata Kloc, Rafal P. Piprek, Jacek Z. Kubiak, Kloc, Malgorzata   +12 more
core   +2 more sources

Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage [PDF]

Journal of Biological Chemistry, 2008
The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein.
Jonathan R, Hall, Hyun O, Lee, Brandon D, Bunker, Elizabeth S, Dorn, Greg C, Rogers, Robert J, Duronio, Jeanette Gowen, Cook   +6 more
openaire   +4 more sources

CDC6 as a pan-cancer immunological and prognostic biomarker and its role in suppressing melanoma malignancy [PDF]

BMC Cancer
Background Cell division cycle 6 (CDC6) is a key licensing factor for DNA replication in the G1 and S phases. Besides initiating replication, CDC6 also helps establish and maintain the S-M checkpoint, ensuring genomic stability.
Lijun Mo, Min Jia, Qian Wu, Qingqing Xu, Zhida Mai, Bo Fu, Zhengqiang He, Mingchang Huang, Yinyuan Lan, Qiaozhen Xu, Zhenmou Xie, Xiaoni He, Yaohua Xue   +12 more
doaj   +2 more sources

Interaction between CDC6 and Tmod3 accelerates resistance to paclitaxel through focal adhesion assembly [PDF]

Signal Transduction and Targeted Therapy
The widespread clinical application of paclitaxel (PTX) in cancer treatment has been significantly limited by the emergence of drug resistance and the presence of drug-tolerant persister cells. To systematically identify key regulators of this resistance,
Yue Liu, Huirui Wang, Jie Zhan, Jiabo Sun, Yan Sun, Xiaojie Fu, Dongxue Lv, Xiuyun Li, Ting Dong, Hongxiang Lou   +9 more
doaj   +2 more sources

Therapeutic efficacy monitoring in canine lymphoma patients via quantifying CDC6 plasma levels [PDF]

BMC Veterinary Research
Background Liquid biopsies have gained increasing recognition as minimally invasive ways to monitor treatment response in cancer patients. They carry circulating DNA, RNA, and proteins in and outside of extracellular vesicles (EVs).
Anne Seijger, Alice Musi, Maurice M. J. M. Zandvliet, Marije E. Kuipers, Nathalie S. M. Lak, Francine E. M. M. van der Steen, Valentina Rinaldi, Laurien R. Feenstra, Godelieve A. M. Tytgat, Esther N. M. Nolte-’t Hoen, Laura Bongiovanni, Alain de Bruin   +11 more
doaj   +2 more sources