Results 51 to 60 of about 8,832 (194)
Study of ORC1/CDC6 from Trypanosoma cruzi
, 2023 A replicação do material genético é essencial para a manutenção e propagação da vida. No caso do DNA em eucariotos, esse processo se inicia pelo Complexo Pré- Replicação (pre-RC). Para sua formação, ocorre o reconhecimento de Origens de Replicação (ORIs)
Pereira, Murilo Leão
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Scientific Reports, 2023 Circular RNAs (circRNA) are known to function as competing endogenous RNA (ceRNA) in various cancers by regulating microRNAs (miRNA). However, in colorectal cancer (CRC), the precise pathological role of circ000240/miRNA/mRNA remains indeterminate.
Ghanbar Mahmoodi Chalbatani +10 more
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Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells [PDF]
, 1998 Cdc6 has a critical regulatory role in the initiation of DNA replication in yeasts, but its function in mammalian cells has not been characterized. We show here that Cdc6 is expressed selectively in proliferating but not quiescent mammalian cells, both ...
Stillman, B. +6 more
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Cdc6 licenses tumor growth [PDF]
Journal of Cell Biology, 2011 ![Figure][1] Unlike control cells (left), cells that overexpress Cdc6 (right) lose E-cadherin (green) from the plasma membrane. Aprotein that permits cells to replicate their DNA also shuts down a tumor suppressor gene, [Sideridou et al.][2] report.
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Multiple Mechanisms Regulate Subcellular Localization of Human CDC6 [PDF]
Journal of Biological Chemistry, 2001 CDC6 is a protein essential for DNA replication, the expression and abundance of which are cell cycle-regulated in Saccharomyces cerevisiae. We have demonstrated previously that the subcellular localization of the human CDC6 homolog, HsCDC6, is cell cycle-dependent: nuclear during G(1) phase and cytoplasmic during S phase.
L M, Delmolino, P, Saha, A, Dutta
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, 2008 BACKGROUND: The human TTC4 protein is a TPR (tetratricopeptide repeat) motif-containing protein. The gene was originally identified as being localized in a genomic region linked to breast cancer and subsequent studies on melanoma cell lines revealed ...
Bennett, D +8 more
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Archives of Medical Science, 2019 Introduction Gastric cancer is one of the most common cancers of the digestive system and is associated with high morbidity and mortality. The aim of this study was to investigate whether miR-26b is involved in the proliferation and resistance to ...
Bochao Zhao +4 more
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BMC Research Notes, 2019 Objective Sulfodiicoccus acidiphilus HS-1T is the type species of the genus Sulfodiicoccus, a thermoacidophilic archaeon belonging to the order Sulfolobales (class Thermoprotei; phylum Crenarchaeota). While S.
Hiroyuki D. Sakai, Norio Kurosawa
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Analysis of Cdc6 function in the assembly of mammalian prereplication complexes [PDF]
Proceedings of the National Academy of Sciences, 2002 Eukaryotic DNA replication requires the previous formation of a prereplication complex containing the ATPase Cdc6 and the minichromosome maintenance (Mcm) complex. Although considerable insight has been gained from in vitro studies and yeast genetics, the functional analysis of replication proteins in intact ...
Jeanette Gowen, Cook +6 more
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Regulation of mammalian CDC6 by CDK phosphorylation and proteasome dependent degradation. [PDF]
, 1999 The mammalian cell cycle is regulated by periodic gene transcription, kinase activities and protein degradation. A human cDNA encoding a protein homologous to S. cerevisiae Cdc6p and S. pombe Cdc18 was identified.
Petersen, Birgit Otzen
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