Results 51 to 60 of about 7,812 (168)

High throughput sequencing revealed enhanced cell cycle signaling in SLE patients

Scientific Reports, 2023
The multi-system involvement and high heterogeneity of systemic lupus erythematosus (SLE) pose great challenges to its diagnosis and treatment. The purpose of the current study is to identify genes and pathways involved in the pathogenesis of SLE.
Mingyue Yang, Peisong Wang, Tao Liu, Xiaojuan Zou, Ying Xia, Chenxu Li, Xiaosong Wang   +6 more
doaj   +1 more source

Executive Function and Epigenetic Markers in Youth Exposed to Family and Community Violence in Childhood

Developmental Psychobiology, Volume 68, Issue 5, September 2026.
ABSTRACT Although exposure to violence has been linked to executive functioning impairments, the biological mechanisms underlying this association remain unclear. This study examined CpG sites associated with executive functions in 78 young adults and their links to family (psychological and physical) and community violence during childhood. The scales
Renata Queiroz Ramos, Cosme Marcelo Furtado Passos da Silva, Adriane Feijó Evangelista, Fernanda Serpeloni, Natasha Reis Lacerda, Joviana Quintes Avanci, Simone Gonçalves de Assis   +6 more
wiley   +1 more source

Uncovering a novel pathway for p16 silencing: Therapeutic implications for lung cancer

Molecular & Cellular Oncology, 2017
A key step during onset of most cases of non-small cell lung cancer (NSCLC) is the loss of the tumor suppressor p16INK4a (best known as p16), commonly due to promoter hypermethylation.
C. Gamell, T. Gulati, B. Solomon, S. Haupt, Y. Haupt   +4 more
doaj   +1 more source

CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression

Biology, 2023
Timely mitosis is critically important for early embryo development. It is regulated by the activity of the conserved protein kinase CDK1. The dynamics of CDK1 activation must be precisely controlled to assure physiologic and timely entry into mitosis ...
Mohammed El Dika, Damian Dudka, Malgorzata Kloc, Jacek Z. Kubiak   +3 more
doaj   +1 more source

Presurgical miR‐675‐5p Associates With the Inflammatory Response Following Surgery and Increases Inflammatory Gene Expression In Vitro

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background A loss of muscle mass and strength is a marker of poor outcomes following surgery. Changes in muscle gene expression following surgery are likely to contribute to postsurgical muscle loss, but the mechanisms controlling these changes are not known. We have previously shown that miRNAs associate with muscle loss in disease, including
Narmin Akhundova, Richard Paul, Benjamin Fletcher, Martin Connolly, Mark J. Griffiths, Paul R. Kemp   +5 more
wiley   +1 more source

Dendritic cell‐specific hypoxia‐inducible factor‐1α deficiency protects mice from recurrent retroviral infection

Experimental Physiology, Volume 111, Issue 8, Page 3843-3856, 1 August 2026.
Abstract Antigen‐processing and ‐presenting cells play a pivotal role in initiation of the antiviral immune response. The cellular adaption of dendritic cells to reduced oxygen and nutrition levels at the site of infection is regulated predominantly by the transcription factor complex hypoxia‐inducible factor‐1 (HIF‐1).
Timm Schreiber, Yvonne Hüsecken, Claudia Lodewick, Simone Schimmer, Gennadiy Zelinskyy, Ulf Dittmer, Kathrin Sutter, Joachim Fandrey, Sandra Winning   +8 more
wiley   +1 more source

Phase Evolution Kinetics in Additive‐Free 19.75% Organic Photovoltaics Empowered by Solvent Vapor Annealing

Advanced Functional Materials, Volume 36, Issue 55, 9 July 2026.
Solvent vapor annealing enables kinetic control of additive‐free morphology in organic solar cells. Selective plasticization of acceptor forms an optimal fibrillar network, boosting efficiency to 19.06% (binary) and 19.75% (ternary), with ultrafast exciton dissociation and reduced recombination.
Jie Lv, Jieni Chen, Cenqi Yan, Patrick W. K. Fong, Jingjing Zhao, Daming Zheng, DingQin Hu, Xiaoman Ding, Xiaokang Sun, Chuanlin Gao, Guangye Zhang, Qianguang Yang, Can Zhu, Pei Cheng, Shirong Lu, Zhipeng Kan, Zhiwei Ren, Guangliu Ran, Wenkai Zhang, Hanlin Hu, Gang Li   +20 more
wiley   +1 more source

The 3 Rs of Cdc6: Recruitment, Regulation, and Replication [PDF]

Current Biology, 2002
What is it? The cell division cycle genes CDC6 and CDC18 encode budding and fission yeast orthologs identified in a series of elegant screens for regulators of cell cycle progression performed independently by Leland Hartwell and Paul Nurse in the 1970s.
openaire   +2 more sources

Cdt1 and Cdc6 Are Destabilized by Rereplication-induced DNA Damage [PDF]

Journal of Biological Chemistry, 2008
The replication factors Cdt1 and Cdc6 are essential for origin licensing, a prerequisite for DNA replication initiation. Mechanisms to ensure that metazoan origins initiate once per cell cycle include degradation of Cdt1 during S phase and inhibition of Cdt1 by the geminin protein.
Jonathan R, Hall, Hyun O, Lee, Brandon D, Bunker, Elizabeth S, Dorn, Greg C, Rogers, Robert J, Duronio, Jeanette Gowen, Cook   +6 more
openaire   +2 more sources

GATA4‐Driven Transcription of HtrA1 Promotes Cellular Senescence in Ménière's Disease and Age‐Related Audio‐Vestibular Dysfunction

Advanced Science, Volume 13, Issue 39, 13 July 2026.
This study identifies the HDAC6/GATA4/HtrA1 axis as a critical driver of cellular senescence in the inner ear. GATA4 nuclear translocation, facilitated by HDAC6 downregulation, transcriptionally activates HtrA1, promoting hair cell senescence, SASP, and audio‐vestibular dysfunction in models of Ménière's disease and age‐related audio‐vestibular ...
Na Zhang, Na Li, Yan Wang, Jing Zhang, Jiahui Liu, Lei Chen, Yongdong Song, Yurong Mu, Yuechen Han, Yafeng Lyu, Xiaofei Li, Hanyue Wang, Jing Wang, Yao Lu, Zhaomin Fan, Daogong Zhang, Haibo Wang   +16 more
wiley   +1 more source