Results 171 to 180 of about 8,832 (194)
Some of the next articles are maybe not open access.
Journal of Cellular Physiology, 2013
AbstractPhosphorylation‐dependent cytoplasmic translocation of human Cdc6 during S phase is sufficient to control its activity after origin firing. Export from the nucleus also serves as a mechanism for preventing re‐replication in mammalian cells. Phosphorylation of the CDK consensus serine residues 54, 74, and 106 has been suggested to be involved in
Hyungshin, Yim +6 more
openaire +2 more sources
AbstractPhosphorylation‐dependent cytoplasmic translocation of human Cdc6 during S phase is sufficient to control its activity after origin firing. Export from the nucleus also serves as a mechanism for preventing re‐replication in mammalian cells. Phosphorylation of the CDK consensus serine residues 54, 74, and 106 has been suggested to be involved in
Hyungshin, Yim +6 more
openaire +2 more sources
Molecular and General Genetics MGG, 1995
When diploid cells of Saccharomyces cerevisiae homozygous for the temperature-sensitive cell division cycle mutation cdc6-1 are grown at a semipermissive temperature they exhibit elevated genomic instability, as indicated by enhanced mitotic gene conversion, mitotic intergenic recombination, chromosomal loss, chromosomal gain, and chromosomal ...
C V, Bruschi +3 more
openaire +2 more sources
When diploid cells of Saccharomyces cerevisiae homozygous for the temperature-sensitive cell division cycle mutation cdc6-1 are grown at a semipermissive temperature they exhibit elevated genomic instability, as indicated by enhanced mitotic gene conversion, mitotic intergenic recombination, chromosomal loss, chromosomal gain, and chromosomal ...
C V, Bruschi +3 more
openaire +2 more sources
Journal of Cellular Physiology, 2018
AbstractRapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA–cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast ...
Xiaoli Kong +8 more
openaire +2 more sources
AbstractRapid proliferation and metastasis of breast cancers resulted in poor prognosis in clinic. Recent studies have proved that long noncoding RNAs (lncRNAs) were involved in tumor progression. In this study, we aimed to determine the roles and mechanisms of lncRNA–cell division cycle 6 (CDC6) in regulating proliferation and metastasis of breast ...
Xiaoli Kong +8 more
openaire +2 more sources
2012
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by
openaire +2 more sources
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by
openaire +2 more sources
Down to the origin: Cdc6 protein and the competence to replicate
Trends in Cell Biology, 2003In eukaryotes, DNA replication requires the regulated assembly of pre-replicative complexes (pre-RCs) onto DNA during G1 phase. Pre-RCs render the chromatin competent to replicate, yet it is only at the G1-S phase transition that protein-kinase complexes trigger the transition to DNA replication.
openaire +2 more sources
Cdc6 and DNA replication: Limited to humble origins
BioEssays, 1996AbstractThe budding yeast Cdc6 protein is important for regulating DNA replication intiation. Cdc6p acts at replication origins, and cdc6‐1 mutants arrest with unreplicated DNA and show elevated minichromosome loss rates. Overexpression of the related Cdc 18 protein in fission yeast results in DNA rereplication; however, Cdc6p overexpression does not ...
openaire +2 more sources
Exploring Bioinformatics Tools to Analyze the Role of CDC6 in the Progression of Polycystic Ovary Syndrome to Endometrial Cancer by Promoting Immune Infiltration [PDF]
International Journal of Molecular SciencesYuhang Zhang, Yizhou Zou, Yao Li
exaly +2 more sources
Cdc6 expression as a marker of proliferative activity in brain tumors
Oncology Reports, 2001Antibodies against human proteins that regulate DNA replication such as Cdc6 and Mcm5 became available as a new marker of proliferation. We performed immunohistochemical analysis with MIB-1 and antibody against Cdc6 on 35 brain tumors, including tumors of neuroepithelial tissue, vestibular schwannomas, meningiomas, and pituitary adenomas.
S, Ohta +5 more
openaire +2 more sources
Cdc6 synthesis regulates replication competence in Xenopus oocytes
Nature, 2002The early division cycles of an embryo rely on the oocyte's ability to replicate DNA. During meiosis, oocytes temporarily lose this ability. After a single round of pre-meiotic S-phase, oocytes enter meiosis and rapidly arrest at prophase of meiosis I (G2).
Elizabeth, Whitmire +2 more
openaire +2 more sources
The role of the replication licensing factor CDC6 in oncogenesis
2022Η ομοιόσταση συνιστά θεμελιώδη ιδιότητα των οργανισμών και εξασφαλίζεται μέσω πληθώρας κυτταρικών αποπκρίσεων έναντι ενδογενών και εξωγενών παραγόντων. Η διαταραχή των μηχανισμών που ελέγχουν τις διαδικασίες αυτές οδηγεί στη συσσώρευση βλαβών και γενικά στην απορρύθμιση της κυτταρικής λειτουργίας με επακόλουθο την εμφάνιση νόσων, όπως ο καρκίνος. Στους
openaire +1 more source