Results 11 to 20 of about 393 (141)

Discovering new hub genes of dilated cardiomyopathy. [PDF]

ESC Heart Fail
Abstract Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of DCM by mining the human DCM databases and further by experimental validation.
Zhu JY, Han Y, Yang JY, Wang DP, Gao LJ, Sun T, Feng YL, He ZM, Zhou B, Cao JM.   +9 more
europepmc   +3 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease. [PDF]

Adv Sci (Weinh)
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Lu H, Zhu Y, Wang X, Wu Z, Xu Z, Chen R, Guo Y.   +6 more
europepmc   +2 more sources

Integrated transcriptomics unveils mitochondrial oxidative phosphorylation dysfunction as a shared mechanism in sarcopenia and obesity. [PDF]

Sci Rep
Sarcopenia and obesity, two prevalent metabolic disorders in aging populations, often coexist and share overlapping pathophysiological mechanisms, yet the molecular mechanisms underlying their comorbidity remain elusive.
Yu R, Miao L, Wang J, Wang D, Liu Y, Wang L, Wang R.   +6 more
europepmc   +2 more sources

Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development. [PDF]

Int J Genomics
Prostate cancer (PCa) is a major malignancy affecting men and is a significant contributor to global male mortality. Over the past decade, several new treatments for advanced PCa have been approved; however, opportunities remain for the development of novel therapeutic strategies.
Arman MAU, Reza MS, Alamin MH, Maya TA, Hossain MT.   +4 more
europepmc   +2 more sources

Integrative analysis identifies shared therapeutic pathways in thyroid eye disease and diabetes mellitus. [PDF]

Sci Rep
Thyroid eye disease (TED) and diabetes mellitus (DM) cause vision loss, with DM aggravating TED. In this study, we aimed to explore the mechanisms of this interaction, and therefore, analyzed gene expression data from representative TED and DM datasets ...
Wang Y, Li H.
europepmc   +2 more sources

Integrative bioinformatics and deep learning to identify common genetic pathways in Crohn's disease and ischemic cardiomyopathy. [PDF]

J Genet Eng Biotechnol
Crohn’s disease (CD) and ischemic cardiomyopathy (ICM) share inflammatory characteristics, yet their common genetic underpinnings remain underexplored.
Maddah R, Aghili ZS, Ghanbari F, Najafabadi AH, Asgary S.   +4 more
europepmc   +2 more sources

The Potential Difference Characteristics between Two Points on Grounding Grid of Substation

Zhongguo dianli, 2021
With the intelligentization upgrade of power substations, a large number of secondary equipment are deployed dispersedly nearby the high-voltage primary equipment. The enclosures of these secondary devices are electrically connected to the grounding grid
Yonghong WANG, Chongqing JIAO, Bing XIAO, Anqi GUO, Guizhong QIU, Lipeng BI, Keqiang XU   +6 more
doaj   +1 more source

Effect of grounding grid of power transmission line on buried pipeline under short circuit fault

You-qi chuyun, 2021
In order to study the electromagnetic interference of the short-circuit current of grounding point when power transmission line is in fault operation, a model for grounding grid of transmission line towers and buried pipelines was established with the ...
Shaojie WANG, Yuanchao HU, Wenlong ZHAO, Xun LI, Dong JING   +4 more
doaj   +1 more source

Exploring common genomic biomarkers to disclose common drugs for the treatment of colorectal cancer and hepatocellular carcinoma with type-2 diabetes through transcriptomics analysis. [PDF]

PLoS One
Type 2 diabetes (T2D) is a crucial risk factor for both colorectal cancer (CRC) and hepatocellular carcinoma (HCC). However, so far, there was no study that has investigated common drugs against HCC and CRC during their co-occurrence with T2D patients ...
Mahmud S, Ajadee A, Sarker A, Ahmmed R, Noor T, Pappu MAA, Islam MS, Mollah MNH.   +7 more
europepmc   +2 more sources

Identification of Differentially Expressed Genes Reveal Conserved Mechanisms in the Rice-Magnaporthe oryzae Interaction

Frontiers in Plant Science, 2022
Magnaporthe oryzae causes rice blast disease and is responsible for major losses in rice production worldwide. Although numerous studies have focused on the interactions between Oryza sativa and M. oryzae, to date, the conserved mechanisms remain in part
Dong Liang, Zhongqiang Qi, Yan Du, Junjie Yu, Mina Yu, Rongsheng Zhang, Huijuan Cao, Xiayan Pan, Junqing Qiao, Tianqiao Song, Youzhou Liu, Zhiyi Chen, Yongfeng Liu   +12 more
doaj   +1 more source