Results 1 to 10 of about 422 (143)

Discovering new hub genes of dilated cardiomyopathy [PDF]

ESC Heart Failure
Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
doaj   +3 more sources

Integrated transcriptomics unveils mitochondrial oxidative phosphorylation dysfunction as a shared mechanism in sarcopenia and obesity [PDF]

Scientific Reports
Sarcopenia and obesity, two prevalent metabolic disorders in aging populations, often coexist and share overlapping pathophysiological mechanisms, yet the molecular mechanisms underlying their comorbidity remain elusive.
Ruixuan Yu, Lei Miao, Jinchao Wang, Dingding Wang, Yajun Liu, Ling Wang, Renxian Wang   +6 more
doaj   +2 more sources

Integrative analysis identifies shared therapeutic pathways in thyroid eye disease and diabetes mellitus [PDF]

Scientific Reports
Thyroid eye disease (TED) and diabetes mellitus (DM) cause vision loss, with DM aggravating TED. In this study, we aimed to explore the mechanisms of this interaction, and therefore, analyzed gene expression data from representative TED and DM datasets ...
Yifei Wang, Hui Li
doaj   +2 more sources

Integrative bioinformatics and deep learning to identify common genetic pathways in Crohn’s disease and ischemic cardiomyopathy [PDF]

Journal of Genetic Engineering and Biotechnology
Crohn’s disease (CD) and ischemic cardiomyopathy (ICM) share inflammatory characteristics, yet their common genetic underpinnings remain underexplored.
Reza Maddah, Zahra Sadat Aghili, Fahimeh Ghanbari, Amirhossein Hajialiasgary Najafabadi, Sedigheh Asgary   +4 more
doaj   +2 more sources

Identification and validation of hub differential genes in pulmonary sarcoidosis [PDF]

Frontiers in Immunology
A total of 138 cDEGs were screened from mediastinal lymph nodes and peripheral whole blood. Among them, 6 hub cDEGs including CTSS, CYBB, FPR2, MNDA, TLR1 and TLR8 with elevated degree and betweenness levels were illustrated in protein-protein ...
Qian Yao, Qian Yao, Keting Min, Mengmeng Zhao, Xianqiu Chen, Dong Weng, Ying Zhou, Ying Zhou   +7 more
doaj   +2 more sources

Exploring common genomic biomarkers to disclose common drugs for the treatment of colorectal cancer and hepatocellular carcinoma with type-2 diabetes through transcriptomics analysis. [PDF]

PLoS ONE
Type 2 diabetes (T2D) is a crucial risk factor for both colorectal cancer (CRC) and hepatocellular carcinoma (HCC). However, so far, there was no study that has investigated common drugs against HCC and CRC during their co-occurrence with T2D patients ...
Sabkat Mahmud, Alvira Ajadee, Arnob Sarker, Reaz Ahmmed, Tasfia Noor, Md Al Amin Pappu, Md Saiful Islam, Md Nurul Haque Mollah   +7 more
doaj   +2 more sources

RETRACTED ARTICLE: Decoding core genes and intercellular communication in osteosarcoma: bioinformatic investigation and immune cell profiling for diagnostic and therapeutic insights

Discover Oncology
The study focusing on developing an artificial neural network (ANN) model in accordance with genetic characteristics of osteosarcoma (OS) to accurately speculate OS cases.
Kuan Rong, Haoming Kuang, Liang Ou, Rui Fang, Jianjun Kuang, Hui Yang   +5 more
doaj   +2 more sources

In-Silico discovery of Pediatric Acute-Myeloid-Leukemia (pAML) causing druggable molecular signatures highlighting their pathogenetic processes and therapeutic agents through single-cell RNA-Seq profile analysis. [PDF]

PLoS ONE
Pediatric acute-myeloid-leukemia (pAML) is an aggressive malignancy and the second most common blood cancer in children. In spite of significant advances in the frontline therapeutic approaches, approximately 50% of pAML patients show poor prognosis and ...
Md Foysal Ahmed, Md Al Noman, Md Feroj Ahmed, Md Abdul Latif, Md Al Amin Pappu, Md Shariful Islam, Md Sanoar Hossain, Md Bayazid Hossen, Md Fahim Faysal, Md Mehedi Hasan, Md Nurul Haque Mollah   +10 more
doaj   +2 more sources

Screening of common genomic biomarkers to explore common drugs for the treatment of pancreatic and kidney cancers with type-2 diabetes through bioinformatics analysis [PDF]

Scientific Reports
Type 2 diabetes (T2D) is a crucial risk factor for both pancreatic cancer (PC) and kidney cancer (KC). However, effective common drugs for treating PC and/or KC patients who are also suffering from T2D are currently lacking, despite the probability of ...
Alvira Ajadee, Sabkat Mahmud, Arnob Sarkar, Tasfia Noor, Reaz Ahmmed, Md. Nurul Haque Mollah   +5 more
doaj   +2 more sources

The Potential Difference Characteristics between Two Points on Grounding Grid of Substation

Zhongguo dianli, 2021
With the intelligentization upgrade of power substations, a large number of secondary equipment are deployed dispersedly nearby the high-voltage primary equipment. The enclosures of these secondary devices are electrically connected to the grounding grid
Yonghong WANG, Chongqing JIAO, Bing XIAO, Anqi GUO, Guizhong QIU, Lipeng BI, Keqiang XU   +6 more
doaj   +1 more source