Results 11 to 20 of about 800 (186)

Discovering new hub genes of dilated cardiomyopathy [PDF]

ESC Heart Failure
Aims Dilated cardiomyopathy (DCM) has a poor prognosis and exhibits a complex and diverse aetiology and genetic profile. The genes responsible for the pathogenesis of DCM have not been fully identified. The present study aimed to explore new hub genes of
Jun‐Yan Zhu, Yu Han, Jing‐Yu Yang, De‐Ping Wang, Li‐Juan Gao, Teng Sun, Yan‐Lin Feng, Zhong‐Mei He, Bin Zhou, Ji‐Min Cao   +9 more
doaj   +3 more sources

Analyzing the pathogenesis of systemic lupus erythematosus complicated by atherosclerosis using transcriptome data [PDF]

Frontiers in Immunology, 2022
BackgroundAccumulating evidence supports the predisposition of systemic lupus erythematosus (SLE) to atherosclerosis (AS). However, the common pathogenesis of these two diseases remains unclear.
Yimin Wang, Wenge Su, Yunlun Li, Jie Yuan, Minghao Yao, Xiaoyi Su, Yifei Wang   +6 more
doaj   +3 more sources

RETRACTED ARTICLE: Decoding core genes and intercellular communication in osteosarcoma: bioinformatic investigation and immune cell profiling for diagnostic and therapeutic insights

Discover Oncology
The study focusing on developing an artificial neural network (ANN) model in accordance with genetic characteristics of osteosarcoma (OS) to accurately speculate OS cases.
Kuan Rong, Haoming Kuang, Liang Ou, Rui Fang, Jianjun Kuang, Hui Yang   +5 more
doaj   +2 more sources

In-Silico discovery of Pediatric Acute-Myeloid-Leukemia (pAML) causing druggable molecular signatures highlighting their pathogenetic processes and therapeutic agents through single-cell RNA-Seq profile analysis. [PDF]

PLoS ONE
Pediatric acute-myeloid-leukemia (pAML) is an aggressive malignancy and the second most common blood cancer in children. In spite of significant advances in the frontline therapeutic approaches, approximately 50% of pAML patients show poor prognosis and ...
Md Foysal Ahmed, Md Al Noman, Md Feroj Ahmed, Md Abdul Latif, Md Al Amin Pappu, Md Shariful Islam, Md Sanoar Hossain, Md Bayazid Hossen, Md Fahim Faysal, Md Mehedi Hasan, Md Nurul Haque Mollah   +10 more
doaj   +2 more sources

Research on the Effects of DC Grounding Electrode of Yanmenguan Converter Station on the Earthing Network of Substation and Windfarm Based on CDEGS Software

Journal of Physics: Conference Series, 2021
Abstract It is of importance to assess the electromagnetic influcence of HVDC converter station on buried metal facilities of AC substations, fossil-fuel plants, windfarms and pipelines. Electromagnetic interference model was established based on the experimental measurement of soil resistivity and actual physical location.
XinJing Cai
exaly   +2 more sources

Screening of common genomic biomarkers to explore common drugs for the treatment of pancreatic and kidney cancers with type-2 diabetes through bioinformatics analysis [PDF]

Scientific Reports
Type 2 diabetes (T2D) is a crucial risk factor for both pancreatic cancer (PC) and kidney cancer (KC). However, effective common drugs for treating PC and/or KC patients who are also suffering from T2D are currently lacking, despite the probability of ...
Alvira Ajadee, Sabkat Mahmud, Arnob Sarkar, Tasfia Noor, Reaz Ahmmed, Md. Nurul Haque Mollah   +5 more
doaj   +2 more sources

Insights into cucumber (Cucumis sativus) genetics: Genome-wide discovery and computational analysis of the Calreticulin Domain-Encoding gene (CDEG) family. [PDF]

Saudi J Biol Sci
Cucumber is an essential vegetable crop throughout the world. Cucumber development is vital for accomplishing both quality and productivity requirements. Meanwhile, numerous factors have resulted in substantial cucumber losses. However, the calreticulin domain-encoding genes (CDEGs) in cucumber were not well-characterized and had little function.
Alam P, Albalawi T.
europepmc   +3 more sources

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease. [PDF]

Adv Sci (Weinh)
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Lu H, Zhu Y, Wang X, Wu Z, Xu Z, Chen R, Guo Y.   +6 more
europepmc   +2 more sources

Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development. [PDF]

Int J Genomics
Prostate cancer (PCa) is a major malignancy affecting men and is a significant contributor to global male mortality. Over the past decade, several new treatments for advanced PCa have been approved; however, opportunities remain for the development of novel therapeutic strategies.
Arman MAU, Reza MS, Alamin MH, Maya TA, Hossain MT.   +4 more
europepmc   +2 more sources

The Potential Difference Characteristics between Two Points on Grounding Grid of Substation

Zhongguo dianli, 2021
With the intelligentization upgrade of power substations, a large number of secondary equipment are deployed dispersedly nearby the high-voltage primary equipment. The enclosures of these secondary devices are electrically connected to the grounding grid
Yonghong WANG, Chongqing JIAO, Bing XIAO, Anqi GUO, Guizhong QIU, Lipeng BI, Keqiang XU   +6 more
doaj   +1 more source