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Single-cell RNA sequencing of shoot apex reveals the mechanism of cyclin regulating cell division via auxin signaling pathway in <i>Populus alba</i>. [PDF]

Front Plant Sci
Liang JH, Wu ZQ, Zhang YX, Yang YB, Wang SY, Gai MY, Wang YW, Zhang XX, Xue J, Duan BH, Yang HL.   +10 more
europepmc   +1 more source

Real-Life Efficacy of Palbociclib and Ribociclib in Advanced Breast Cancer. [PDF]

Curr Oncol
Avci T, Sahbazlar M, Ekinci F, Erdogan AP.   +3 more
europepmc   +1 more source

Principles of CDK regulation [PDF]

Nature, 1995
As key regulators of the cell cycle, the cyclin-dependent kinases must be tightly regulated by extra- and intracellular signals. The activity of cyclin-dependent kinases is controlled by four highly conserved biochemical mechanisms, forming a web of regulatory pathways unmatched in its elegance and intricacy.
D. Morgan
semanticscholar   +3 more sources

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Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures.

European Journal of Medicinal Chemistry, 2019
The cyclin-dependent protein kinases (CDKs) are protein-serine/threonine kinases that display crucial effects in regulation of cell cycle and transcription. While the excessive expression of CDKs is intimate related to the development of diseases including cancers, which provides opportunities for disease treatment.
W. Cheng, Zhiheng Yang, Su-hua Wang, Ying Li, Han Wei, X. Tian, Q. Kan   +6 more
semanticscholar   +4 more sources

Recent advances on cyclins, CDKs and CDK inhibitors

Trends in Cell Biology, 1997
In eukaryotes, cell division is controlled by cyclin-dependent kinases (CDKs). Here we summarize a few new developments on the regulation of the cell cycle by CDK-cyclin complexes. We have focused on three aspects in which there has been recent progress: the structural analysis of these complexes, the phenotypes of mice carrying knockouts of CDK ...
Cristina Martín-Castellanos, Moreno
openaire   +3 more sources

Small Molecule CDK Inhibitors for the Therapeutic Management of Cancer.

Current Topics in Medicinal Chemistry, 2020
Cyclin-dependent kinases (CDKs) is a group of multifunctional enzymes consisting of catalytic and regulatory subunits. The regulatory subunit, cyclin remain dissociated under normal circumstances, complexation of cyclin with the catalytic subunit of CDK ...
Bharat Goel, Nancy Tripathi, Nivedita Bhardwaj, Shreyans K. Jain   +3 more
semanticscholar   +1 more source

Regulation of CDKs by phosphorylation

1998
The key transitions of the cell cycle are controlled via the sequential activation and inactivation of members of the cyclin-dependent kinase (CDK) subfamily of protein kinases. The activities of these enzymes are regulated by multiple mechanisms including both activating and inactivating phosphorylations, binding to regulatory subunits termed cyclins,
Mark J. Solomon, Philipp Kaldis
openaire   +3 more sources