Results 211 to 220 of about 405,232 (337)

Functional rescue of a bacterial dapA auxotroph with a plant cDNA library selects for mutant clones encoding a feedback-insensitive dihydrodipicolinate synthase [PDF]

, 2000
Marc Vauterin, Valérié Frankard, M. F. Jacobs   +2 more
openalex   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

Advanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui, Furong Huang, Kun Fang, Jingyue Yan, Yuebao Zhang, Diana D. Kang, Yufan Zhou, Yue Zhao, Jeffrey I. Everitt, William Hankey, Andrew J Armstrong, Jiaoti Huang, Hongyan Wang, Victor X. Jin, Yizhou Dong, Qianben Wang   +15 more
wiley   +1 more source

Sequencing of first-strand cDNA library reveals full-length transcriptomes. [PDF]

Nat Commun, 2015
Agarwal S, Macfarlan TS, Sartor MA, Iwase S.   +3 more
europepmc   +1 more source

LncRNA‐MEG3 Regulates Muscle Mass and Metabolic Homeostasis by Facilitating SUZ12 Liquid–Liquid Phase Separation

Advanced Science, EarlyView.
This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao, Chao Yan, Haibo Huang, Shilong Wang, Jiaying Li, Yun Chen, Xiaolu Qu, Qi Bao, Lingna Xu, Yuanyuan Zhang, Danyang Fan, Xia He, Yanwen Liu, Yongsheng Zhang, Yalan Yang, Zhonglin Tang   +15 more
wiley   +1 more source

Novel cDNA fragment associated with gastric cancer drug resistance was screened out from a library by monoclonal antibody MGr1

, 1998
Daiming Fan, Bing Xiao, Yongquan Shi, Mingfeng, Taidong Qiao, Baojun Chen, Zhen Chen   +6 more
openalex   +1 more source

PABPN1 Couples the Polyadenylation and Translation of Maternal Transcripts to Mouse Oocyte Meiotic Maturation

Advanced Science, EarlyView.
This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai, Yu‐Ke Wu, Shuai‐Bo Pi, Feng‐Jie Hu, Yun‐Wen Wu, Hang Qi, Zhiyi Li, Zhi‐Yan Jiang, Long‐Wen Zhao, Heng‐Yu Fan   +9 more
wiley   +1 more source

Construction of a cDNA library for miniature pig mandibular deciduous molars. [PDF]

BMC Dev Biol, 2014
Song T, Wu T, Wei F, Li A, Wang F, Xie Y, Liu D, Fan Z, Wang X, Cheng S, Zhang C, He J, Wang S.   +12 more
europepmc   +1 more source

CONSTRUCTION OF SUBTRACTED OSTEOBLAST cDNA LIBRARY WITH LASER-IRRADIATION-ENHANCED TRANSCRIPTION

, 1997
Shiki Hosoya, Kazutoshi Tamura, Kazushi Nomura, Yoshimitsu Abiko   +3 more
openalex   +2 more sources

Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library [PDF]

, 2000
Anna R. Derubeis, Marian F. Young, Lee Jia, Pamela Gehron Robey, Larry W. Fisher   +4 more
openalex   +1 more source

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source