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Coenzyme Q10 as a potent compound that inhibits Cdt1–geminin interaction
Biochimica et Biophysica Acta (BBA) - General Subjects, 2008A human replication initiation protein Cdt1 is a very central player in the cell cycle regulation of DNA replication, and geminin down-regulates Cdt1 function by directly binding to it. It has been demonstrated that Cdt1 hyperfunction resulting from Cdt1-geminin imbalance, for example by geminin silencing with siRNA, induces DNA re-replication and ...
Yoshiyuki, Mizushina +10 more
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Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma
Journal of Gastrointestinal Surgery, 2016Genomic instability is a common feature in hepatocellular carcinoma. Deregulation of replication licensing factors has been shown to trigger DNA damage response contributing to genomic instability. Overexpression of DNA replication licensing factors chromatin licensing and DNA replication factor 1 (CDT1) and minichromosome maintenance complex component
Dimitrios, Karavias +6 more
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Structural basis for inhibition of the replication licensing factor Cdt1 by geminin
Nature, 2004To maintain chromosome stability in eukaryotic cells, replication origins must be licensed by loading mini-chromosome maintenance (MCM2-7) complexes once and only once per cell cycle. This licensing control is achieved through the activities of geminin and cyclin-dependent kinases.
Lee, C +9 more
openaire +3 more sources
CDT1 inhibits CMG helicase in early S phase to separate origin licensing from DNA synthesis
Molecular Cell, 2023Nalin Ratnayeke +2 more
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Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis
EMBO Journal, 2006Hideo Nishitani +2 more
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