Results 161 to 170 of about 6,157 (185)

Multiple Cdt1 molecules act at each origin to load replication‐competent Mcm2–7 helicases

EMBO Journal, 2011
Eukaryotic origins of replication are selected by loading a head-to-head double hexamer of the Mcm2-7 replicative helicase around origin DNA. Cdt1 plays an essential but transient role during this event; however, its mechanism of action is unknown ...
Stephen P. Bell
exaly   +1 more source

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Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction‡

Journal of Peptide Science, 2015
Six all‐hydrocarbon‐stapled Cdt1 MBD‐derived peptides have been designed and synthesized to perturb the Cdt1–Mcm6 interaction, which is involved in DNA replication. Inconsistency between the helicity of the obtained peptidomimetics and their binding affinity has been observed.
Xuechen Li, Guang Zhu
exaly   +5 more sources

Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis☆

Experimental Cell Research, 2004
Cdt1 is a conserved replication factor required in licensing the chromosome for a single round of DNA synthesis. The activity of Cdt1 is inhibited by geminin. The mechanism by which geminin interferes with Cdt1 activity is unknown. It is thought that geminin binds to and sequestrate Cdt1.
Domenico, Maiorano, Wilfrid, Rul, Marcel, Méchali   +2 more
openaire   +2 more sources

The Cdt1 protein is required to license DNA for replication in fission yeast

Nature, 2000
To maintain genome stability in eukaryotic cells, DNA is licensed for replication only after the cell has completed mitosis, ensuring that DNA synthesis (S phase) occurs once every cell cycle. This licensing control is thought to require the protein Cdc6 (Cdc18 in fission yeast) as a mediator for association of minichromosome maintenance (MCM) proteins
H, Nishitani, Z, Lygerou, T, Nishimoto, P, Nurse   +3 more
openaire   +2 more sources

PCNA-Dependent Ubiquitination of Cdt1 and p21 in Mammalian Cells

2014
PCNA is a DNA clamp, acting on chromatin as a platform for various proteins involved in many aspects of DNA replication-linked processes. Most of these proteins have the PCNA-interaction protein motif (PIP box) that associates with PCNA. Recent works show that PCNA plays an important role as a matchmaker, connecting PCNA-interacting proteins to the ...
Akiyo, Hayashi, Naohiro, Suenaga, Yasushi, Shiomi, Hideo, Nishitani   +3 more
openaire   +2 more sources

Essential role of human CDT1 in DNA replication and chromatin licensing

Journal of Cell Science, 2002
Formation of pre-replicative complexes at origins is an early cell cycle event essential for DNA duplication. A large body of evidence supports the notion that Cdc6 protein, through its interaction with the origin recognition complex, is required for pre-replicative complex assembly by loading minichromosome maintenance proteins onto DNA.
Mickael, Rialland, Francesco, Sola, Corrado, Santocanale   +2 more
openaire   +2 more sources

Coenzyme Q10 as a potent compound that inhibits Cdt1–geminin interaction

Biochimica et Biophysica Acta (BBA) - General Subjects, 2008
A human replication initiation protein Cdt1 is a very central player in the cell cycle regulation of DNA replication, and geminin down-regulates Cdt1 function by directly binding to it. It has been demonstrated that Cdt1 hyperfunction resulting from Cdt1-geminin imbalance, for example by geminin silencing with siRNA, induces DNA re-replication and ...
Yoshiyuki, Mizushina, Toshifumi, Takeuchi, Yoichi, Takakusagi, Yuko, Yonezawa, Takeshi, Mizuno, Ken-Ichiro, Yanagi, Naoko, Imamoto, Fumio, Sugawara, Kengo, Sakaguchi, Hiromi, Yoshida, Masatoshi, Fujita   +10 more
openaire   +2 more sources

Cdt1 and Geminin in cancer: markers or triggers of malignant transformation?

Frontiers in Bioscience, 2008
Cdt1 and its inhibitor Geminin are important regulators of replication licensing. In normal cells, a critical balance between these two proteins ensures that firing of each origin along the genome will take place only once per cell cycle. Cdt1 overexpression in cell lines and animals leads to aberrant replication, activates DNA damage checkpoints and ...
Chariklia, Petropoulou, Panorea, Kotantaki, Dimitris, Karamitros, Stavros, Taraviras   +3 more
openaire   +2 more sources

Overexpression of CDT1 Is a Predictor of Poor Survival in Patients with Hepatocellular Carcinoma

Journal of Gastrointestinal Surgery, 2016
Genomic instability is a common feature in hepatocellular carcinoma. Deregulation of replication licensing factors has been shown to trigger DNA damage response contributing to genomic instability. Overexpression of DNA replication licensing factors chromatin licensing and DNA replication factor 1 (CDT1) and minichromosome maintenance complex component
Dimitrios, Karavias, Ioannis, Maroulis, Helen, Papadaki, Charalambos, Gogos, Stavros, Kakkos, Dionissios, Karavias, Vasiliki, Bravou   +6 more
openaire   +2 more sources

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin

Nature, 2004
To maintain chromosome stability in eukaryotic cells, replication origins must be licensed by loading mini-chromosome maintenance (MCM2-7) complexes once and only once per cell cycle. This licensing control is achieved through the activities of geminin and cyclin-dependent kinases.
Lee, C, Hong, B, Choi, JM, Kim, Y, Watanabe, S, Ishimi, Y, Enomoto, T, Tada, S, Kim, YC, Cho, YJ   +9 more
openaire   +3 more sources