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Geminin–Cdt1 balance is critical for genetic stability
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005A cell limits its DNA replication activity to once per cell division cycle to maintain its genomic integrity. Studies in a variety of organisms are elucidating how these controls are exercised. Key amongst these is the regulation of replication initiator proteins such as Cdt1.
Anindya Dutta
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AbstractColorectal carcinoma (CRC) is one of the most common forms of malignancy in the Western world. Recent decades have witnessed enormous progress in our understanding of the mechanisms that sustain CRC, even though the factors implicated in the initiation and progression of this neoplasia are not fully understood.
Giovanni Monteleone, Carmine Stolfi
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Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53 [PDF]
Oncogene, 2005 The exact duplication of chromosomal DNA during each cell cycle ensures the correct inheritance of genetic material from mother to daughter cells. In eukaryotic cells, DNA replication can occur only when the origin of DNA replication is accurately marked by a group of proteins termed licensing proteins.
Girdhar G Sharma +2 more
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Multiple Cdt1 molecules act at each origin to load replication‐competent Mcm2–7 helicases
EMBO Journal, 2011 Eukaryotic origins of replication are selected by loading a head-to-head double hexamer of the Mcm2-7 replicative helicase around origin DNA. Cdt1 plays an essential but transient role during this event; however, its mechanism of action is unknown ...
Stephen P Bell
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Cdt1 and Geminin in DNA Replication Initiation
2012One of the mechanisms controlling the initiation of DNA replication is the dynamic interaction between Cdt1, which promotes assembly of the pre-replication license complex, and Geminin, which inhibits it. Specifically, Cdt1 cooperates with the cell cycle protein Cdc6 to promote loading of the minichromosome maintenance helicases (MCM) onto the ...
Christophe, Caillat +1 more
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Development of stapled helical peptides to perturb the Cdt1–Mcm6 interaction
Journal of Peptide Science, 2015Six all‐hydrocarbon‐stapled Cdt1 MBD‐derived peptides have been designed and synthesized to perturb the Cdt1–Mcm6 interaction, which is involved in DNA replication. Inconsistency between the helicity of the obtained peptidomimetics and their binding affinity has been observed.
Guang Zhu, Xuechen Li
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Cell cycle regulation of the licensing activity of Cdt1 in Xenopus laevis☆
Experimental Cell Research, 2004Cdt1 is a conserved replication factor required in licensing the chromosome for a single round of DNA synthesis. The activity of Cdt1 is inhibited by geminin. The mechanism by which geminin interferes with Cdt1 activity is unknown. It is thought that geminin binds to and sequestrate Cdt1.
Domenico, Maiorano +2 more
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The Cdt1 protein is required to license DNA for replication in fission yeast
Nature, 2000To maintain genome stability in eukaryotic cells, DNA is licensed for replication only after the cell has completed mitosis, ensuring that DNA synthesis (S phase) occurs once every cell cycle. This licensing control is thought to require the protein Cdc6 (Cdc18 in fission yeast) as a mediator for association of minichromosome maintenance (MCM) proteins
H, Nishitani +3 more
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PCNA-Dependent Ubiquitination of Cdt1 and p21 in Mammalian Cells
2014PCNA is a DNA clamp, acting on chromatin as a platform for various proteins involved in many aspects of DNA replication-linked processes. Most of these proteins have the PCNA-interaction protein motif (PIP box) that associates with PCNA. Recent works show that PCNA plays an important role as a matchmaker, connecting PCNA-interacting proteins to the ...
Akiyo, Hayashi +3 more
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Essential role of human CDT1 in DNA replication and chromatin licensing
Journal of Cell Science, 2002Formation of pre-replicative complexes at origins is an early cell cycle event essential for DNA duplication. A large body of evidence supports the notion that Cdc6 protein, through its interaction with the origin recognition complex, is required for pre-replicative complex assembly by loading minichromosome maintenance proteins onto DNA.
Mickael, Rialland +2 more
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