Journal of Cellular and Molecular Medicine, Volume 30, Issue 7, April 2026.ABSTRACT Cornus officinalis (CO) is a traditional herbal medicine renowned in Traditional Chinese Medicine (TCM) for its properties of tonifying the liver and kidney and replenishing vital essence. Meanwhile, wine‐processed CO (pCO) exhibits superior pharmacological effects, including anti‐inflammatory, antioxidant and anti‐fibrotic activities. However,
Yongsheng Fu +4 more
wiley +1 more source
HeliyonBackground: OA imposes a heavy burden on patients and society in that its mechanism is still unclear, and there is a lack of effective targeted therapy other than surgery.
Ping Hu +8 more
doaj +1 more source
Gene Expression and Immunohistochemistry in Adipose Tissue of HIV Type 1-Infected Patients with Nucleoside Analogue Reverse-Transcriptase Inhibitor-Associated Lipoatrophy [PDF]
, 2017 BackgroundLong-term use of both zidovudine (AZT) and stavudine (d4T) is associated with lipoatrophy, but it occurs possibly through different mechanisms MethodsSurgical biopsy specimens of subcutaneous adipose tissue were obtained from 18 human ...
Eriksson, P. +7 more
core
Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression
Italian Journal of Pediatrics, 2018 Background Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis of the disease.
Li Huang +4 more
doaj +1 more source
E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. [PDF]
, 2019 Objective: Since the introduction in 2004, global usage of e-cigarettes (ECs) has risen exponentially. However, the risks of ECs on oral health are uncertain.
Chen, Wei +9 more
core
ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion
PNAS NexusAbstract ZHX3, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of ZHX3 in the human pancreatic β-cell line EndoC-βH1 did not impair
Wei Xuan Tan +12 more
openaire +2 more sources
Design and Evaluation of RNA Aptamer–Mediated Delivery of C/EBPβ siRNA for Oncological Therapy
Journal of Nucleic AcidsThe CCAAT/enhancer-binding protein beta (CEBPB or C/EBPβ) is a transcription factor that plays a critical role in cellular differentiation, metabolism, and immune response.
D. Vasconcelos +9 more
doaj +1 more source
Molecular mechanisms of atherosclerosis in metabolic syndrome: role of reduced IRS2-dependent signaling [PDF]
, 2008 OBJECTIVE: The mechanisms underlying accelerated atherosclerosis in metabolic syndrome (MetS) patients remain poorly defined. In the mouse, complete disruption of insulin receptor substrate-2 (Irs2) causes insulin resistance, MetS-like manifestations ...
Andres, V. (Vicente) +8 more
core
Transcriptional Response to Acute Thermal Exposure in Juvenile Chinook Salmon Determined by RNAseq. [PDF]
, 2015 Thermal exposure is a serious and growing challenge facing fish species worldwide. Chinook salmon (Oncorhynchus tshawytscha) living in the southern portion of their native range are particularly likely to encounter warmer water due to a confluence of ...
Baerwald, Melinda R +6 more
core
Bioinformatics identification and validation of pyroptosis-related gene for ischemic stroke
BMC Medical GenomicsBackground Ischemic stroke (IS) is one of the common and frequent diseases with extremely high lethality and disability in the world, and there is no effective treatment at present.
Xinying Shang +4 more
doaj +1 more source