Results 101 to 110 of about 10,239 (195)

ZHX3 interacts with CEBPB to repress hepatic gluconeogenic gene expression and uric acid secretion

PNAS Nexus
Abstract ZHX3, which encodes for a transcriptional repressor, is associated with fasting blood glucose (FBG) levels and increased type 2 diabetes (T2D) risk but its role in cell types involved in glucose metabolism is not well understood. Here, we show that the deletion of ZHX3 in the human pancreatic β-cell line EndoC-βH1 did not impair
Wei Xuan Tan, Lillian Yuxian Lim, Nesha Afsha, Gloria Mei En Chan, Carmen Ching, Gokce Oguz, Suat Peng Neo, Safiah Mohamed Ali, Adaikalavan Ramasamy, Jayantha Gunaratne, Walter Hunziker, Chin Meng Khoo, Adrian Kee Keong Teo   +12 more
openaire   +2 more sources

Activation of KRT5, KRT14 and KRT17 enhancers mark the functional CEBPB activation.

, 2018
A, Schematic showing the enhancer regulatory factors that map to C19MC start site. B, RNASeq data showing CEBPB expression in C19MC-based patient groups.
Andrew S. Brohl (596305), Elsa R. Flores (258494), Goodwin G. Jinesh (5870897)   +2 more
core   +1 more source

Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression

Italian Journal of Pediatrics, 2018
Background Neonatal sepsis is an inflammatory systemic syndrome, which is a major cause of morbidity and mortality in premature infants. We analyzed the expression profile data of E-MTAB-4785 to reveal the pathogenesis of the disease.
Li Huang, Lixing Qiao, Huan Zhu, Li Jiang, Liping Yin   +4 more
doaj   +1 more source

SMAD1,5,8 phosphorylation in hrBMP2-treated human endometrial stromal cells and SMAD1/5 and CEBPB ChIP experiments.

, 2013
A) Phosphorylation of SMAD1,5,8 in hESC treated with 100 ng/ml hrBMP2 for 0 (non treated = NT), 30, 45, 60 minutes, 3 or 6 hours. B-ACTIN was used as loading control. B) Phosphorylation of SMAD1,5,8 in hESC transfected with NT (left) or ALK2 siRNA (right)
Shannon M. Hawkins (251961), Swamy K. Tripurani (464062), Michael J. Large (485131), Stephanie A. Pangas (485132), Caterina Clementi (485130), Vesa Kaartinen (38989), Mark A. Edson (200197), John P. Lydon (476343), Francesco J. DeMayo (143652), Chad J. Creighton (81967), Martin M. Matzuk (200210), Ertug Kovanci (476340)   +11 more
core   +1 more source

Design and Evaluation of RNA Aptamer–Mediated Delivery of C/EBPβ siRNA for Oncological Therapy

Journal of Nucleic Acids
The CCAAT/enhancer-binding protein beta (CEBPB or C/EBPβ) is a transcription factor that plays a critical role in cellular differentiation, metabolism, and immune response.
D. Vasconcelos, M. H. Sodergren, V. Reebye, J. Vasara, M. S. Song, K. Holm, S. E. Khorsandi, J. Rossi, N. Habib, K. W. Huang   +9 more
doaj   +1 more source

Transcription Factor CEBPB Inhibits the Expression of the Human HTR1A by Binding to 5′ Regulatory Region In Vitro

, 2019
This study identified a transcription factor that might bind to the 5′ regulatory region of the HTR1A and explored the potential effect on 5-HT1A receptor expression.
Yong-Ping Liu, Jing-Hua Meng, Jing-Jing Zhang, Bao-Jie Wang, Jun Yao, Mei Ding, Xue Wu, Feng-Ling Xu   +7 more
core   +1 more source

Image_1_Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.JPEG

, 2019
Hypoxia is a predominant feature in glioblastoma (GBM) and contributes greatly to its drug resistance. However, the molecular mechanisms which are responsible for the development of the resistant phenotype of GBM under hypoxic conditions remain unclear ...
Yixing Gao (6287018), Bo Zhu (118038), Shu He (530569), Binda Sun (6287021), Guoji E (6287024), Yuqi Gao (517483), Lan Feng (1879297), Bao Liu (136109), Chang Liu (35901), Erlong Zhang (6287027), Gang Wu (23885), Yidong Yang (2089252)   +11 more
core   +2 more sources

Amphiregulin and Epiregulin Confer Radioresistance in Esophageal Squamous Cell Carcinoma Through Oxidative Phosphorylation

Advanced Science
Neoadjuvant chemoradiotherapy (nCRT) improves outcomes for locally advanced esophageal squamous cell carcinoma (ESCC) but exhibits variable efficacy due to heterogeneous radiosensitivity.
Zhang Lin, Meilian Yao, Xin Xu, Dong Zhang, Lei Xu, Ling Rong, Xiaohang Wang, Yi Duan, Chengkun Chen, Jun Gu, Yao Zhang, Qiang Liu, Qing Ye, Gaoping Cui, Yujun Hao, Xiumei Ma   +15 more
doaj   +1 more source

Bioinformatics identification and validation of pyroptosis-related gene for ischemic stroke

BMC Medical Genomics
Background Ischemic stroke (IS) is one of the common and frequent diseases with extremely high lethality and disability in the world, and there is no effective treatment at present.
Xinying Shang, Rui Wei, Di Yang, Bawei Yu, Wei Zhang   +4 more
doaj   +1 more source

A CEBPB/TYMP/GDF15 signaling axis mediates tumor growth and cisplatin resistance in bladder cancer

Translational Oncology
Cisplatin-based chemotherapy remains the standard treatment for muscle-invasive bladder cancer (BC), yet resistance significantly limits its long-term efficacy. Reliable biomarkers for prognosis and therapeutic guidance are also lacking. Here, we identify thymidine phosphorylase (TYMP) as an independent prognostic risk factor that promotes BC ...
Tian, Shuo, Wang, Chuang, Zhao, Xupeng, Xuan, Yundong, Wei, Wenjie, Dong, Yuhao, Tao, Wen, Zhang, Chi, Cai, Tianwei, Liu, Chunyu, Huang, Yan, Zhang, Xu   +11 more
openaire   +2 more sources