Results 101 to 110 of about 13,695 (188)

The bZIP mutant CEBPB (V285A) has sequence specific DNA binding propensities similar to CREB1

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2019
The bZIP homodimers CEBPB and CREB1 bind DNA containing methylated cytosines differently. CREB1 binds stronger to the C/EBP half-site GCAA when the cytosine is methylated. For CEBPB, methylation of the same cytosine does not affect DNA binding. The X-ray structure of CREB1 binding the half site GTCA identifies an alanine in the DNA binding region ...
Sreejana Ray, Aniekanabasi Ufot, Nima Assad, Jocelyn Singh, Stewart R. Durell, Aleksey Porollo, Desiree Tillo, Charles Vinson   +7 more
openaire   +3 more sources

Functional validation of the anaplastic lymphoma kinase signature identifies CEBPB and Bcl2A1 as critical target genes [PDF]

Journal of Clinical Investigation, 2006
Anaplastic large cell lymphomas (ALCLs) represent a subset of lymphomas in which the anaplastic lymphoma kinase (ALK) gene is frequently fused to the nucleophosmin (NPM) gene. We previously demonstrated that the constitutive phosphorylation of ALK chimeric proteins is sufficient to induce cellular transformation in vitro and in vivo and that ALK ...
PIVA, Roberto, PELLEGRINO, Elisa, MATTIOLI M, AGNELLI L, LOMBARDI L, BOCCALATTE F, COSTA, G, RUGGERI BA, CHENG M, CHIARLE, Roberto, PALESTRO, Giorgio, NERI A, INGHIRAMI, Giorgio   +12 more
openaire   +3 more sources

C/EBPβ deletion in macrophages impairs mammary gland alveolar budding during the estrous cycle

Life Science Alliance
Macrophage C/EBPβ contributes to alveolar budding during the estrous cycle by providing critical signaling to mammary epithelial cells. Macrophages have important roles in mammary gland development and tissue homeostasis, but the specific mechanisms that
Michelle D Rojo, Ishitri Bandyopadhyay, Caitlin M Burke, Alexa D Sturtz, Emily S Phillips, Megan G Matherne, Samuel J Embrey, Rebecca LaRue, Yinjie Qiu, Kathryn L Schwertfeger, Heather L Machado   +10 more
doaj   +1 more source

Spatial and single‐cell RNA sequencing reveals the immune microenvironment of human ascending thoracic aortic aneurysms

Clinical and Translational Medicine, Volume 16, Issue 4, April 2026.
This study has used integrated single‐cell RNA sequencing and Visium HD spatial transcriptomics to construct a high‐resolution immune cell atlas of human ascending thoracic aortic aneurysms (ATAA). The analysis reveals distinct immune cell composition and interactions in ATAA tissues, providing new insights into immune dysregulation and vascular ...
Ke Zhen, Zhiyong Du, Pengcheng Wang, Song Liu, Junming Zhu, Zhiyu Qiao, Hongfeng Jiang   +6 more
wiley   +1 more source

CEBPB regulates ERK1/2 activity through SOS1 and contributes to ovarian cancer progression. [PDF]

Med Oncol
Ovarian cancer (OC) is among the most prevalent malignant tumors affecting the female reproductive system. Notably, CEBPB has emerged as a highly promising biomarker, attracting substantial attention for its role in mediating chemotherapy resistance to PARP inhibitors (PARPi).
Tan J, Wang D, Tu A, Xu Q, Zhuan L, Wu X, Zhao L, Dong W, Zhang J, Feng Y.   +9 more
europepmc   +2 more sources

Single‐Cell Profiling Reveals RAB13+ Endothelial Cells and Profibrotic Mesenchymal Cells in Aged Human Bone Marrow

Aging Cell, Volume 25, Issue 4, April 2026.
Integrated single‐cell, spatial transcriptomic, and immunofluorescence analyses reveal profound aging‐associated remodeling of the non‐immune human bone marrow niche. Aging is marked by endothelial dysfunction, emergence of RAB13+ arterial endothelial cells, and expansion of profibrotic THY1+ mesenchymal cells, identifying potential cellular targets ...
Itziar Cenzano, Miguel Cócera, Ana Rosa Lopez‐Perez, Lorea Campos‐Dopazo, Javier Ruiz, Ignacio Sancho, Patxi San Martin‐Uriz, Paula Aguirre‐Ruiz, Sarai Sarvide, Amaia Vilas‐Zornoza, Purificacion Ripalda‐Cemborain, Diego Alignani, Aitziber Lopez, Marta Miñana Barrios, Delia Quilez Agreda, Jin Ye, Robert Lehmann, Laura Sudupe, Marta Abengozar‐Muela, Álvaro Lopez‐Janeiro, Luis‐Esteban Tamariz‐Amador, Emma Muiños‐López, Borja Saez, Jesper Tegner, Isabel A. Calvo, David Gomez‐Cabrero, Felipe Prosper   +26 more
wiley   +1 more source

Inhibition of HCV by the serpin antithrombin III [PDF]

, 2012
Background: Although there have been dramatic strides made recently in the treatment of chronic hepatitis C virus infection, interferon-α based therapy remains challenging for certain populations, including those with unfavorable IL28B genotypes ...
Asmal, Mohammed, Chung, Raymond Taeyong, Geiben-Lynn, Ralf, Letvin, Norman L, Lin, Wenyu, Seaman, Michael S.   +5 more
core   +2 more sources

Identification of key genes and novel immune infiltration-associated biomarkers of sepsis

Innate Immunity, 2020
Sepsis is the major cause of mortality in the intensive care unit. The aim of this study was to identify the key prognostic biomarkers of abnormal expression and immune infiltration in sepsis.
Chao Xu, Jianbo Xu, Ling Lu, Wendan Tian, Jinling Ma, Meng Wu   +5 more
doaj   +1 more source

Molecular Markers Distinguishing Early‐Stage Mycosis Fungoides From Atopic Dermatitis Skin Lesions

Experimental Dermatology, Volume 35, Issue 4, April 2026.
ABSTRACT Mycosis fungoides (MF) is the most common type of primary cutaneous T‐cell lymphoma, a disease characterized by malignant T cells that home to the skin. In early stages, clinical presentation is often indistinguishable from benign chronic inflammatory skin diseases such as atopic dermatitis (AD), posing a challenge for proper diagnosis and ...
Brandon D. Ng, Conor Whelan, Natalia Alkon, Agata Kurowski, Constanze Jonak, Patrick M. Brunner   +5 more
wiley   +1 more source

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOST.

PLoS ONE
A haplotype block at the sclerostin (SOST) gene correlates with bone mineral density (BMD) and increased periodontitis risk in smokers. Investigating the putative causal variants within this block, our study aimed to elucidate the impact of linked ...
Avneesh Chopra, Jiahui Song, January Weiner Rd, Dieter Beule, Arne S Schaefer   +4 more
doaj   +1 more source