Results 81 to 90 of about 10,239 (195)

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Additional file 1 of CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFκB signaling pathway

, 2022
Additional file 1: Figure S1. (A) GSE145608 revealed the expression profile of hsa_circRNA_002141 (circZDBF2) in oral cancer cell lines and human normal control cell line. (B) CircZDBF2 expression was silenced in SCC9 and SCC15 cells via the transfection
Bingyao Liu (6428873), Lei Zhu (16642), Juan Liu (6492), Yi Shuai (9176540), Bo Chen (32294), Ke Liu (121889), Maodian He (12336562), Junxia Li (136291), Lei Jin (120473), Xiaolei Shi (319891), Xinyao He (3109851), Liang Rong (3800992)   +11 more
core   +1 more source

Single‐Cell Transcriptomic Identification of Drug‐Tolerant Persister Mechanisms in Capecitabine‐Treated Triple‐Negative Breast Cancer

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype defined by the absence of estrogen receptor (ER), progesterone receptor (PR), and HER2 expression. This lack of receptors limits targeted therapies and contributes to high rates of recurrence.
Md Naiyem Islam, Md Kaziul Islam Sarkar Suja, Alif Al Takbir, Md. Kaderi Kibria   +3 more
wiley   +1 more source

Deletion of Cebpb has no effect on lung structure, but leads to aggregation of lymphoid cells in the lung.

, 2015
(A) Immunoblots of lung extracts from Cebpb+/+ or Cebpb-/- mice. Note that the predominant isoform expressed in mouse lungs is LAP and C/EBPβ expression in the lung is effectively lost in Cebpb-/- mice.
Ayako Hirata (701756), Mihoko Yamamoto (701760), Hideo Watanabe (701762), Kwok-Kin Wong (165223), Daniel B. Costa (701761), Sohei Nakayama (701757), Paul A. VanderLaan (701758), Elena Levantini (701759), Hideyo Hirai (247643), Susumu S. Kobayashi (701763), Yi Cai (233861)   +10 more
core   +1 more source

Identification of key genes and novel immune infiltration-associated biomarkers of sepsis

Innate Immunity, 2020
Sepsis is the major cause of mortality in the intensive care unit. The aim of this study was to identify the key prognostic biomarkers of abnormal expression and immune infiltration in sepsis.
Chao Xu, Jianbo Xu, Ling Lu, Wendan Tian, Jinling Ma, Meng Wu   +5 more
doaj   +1 more source

Exosomal PSMD1 Derived From Dental Pulp Mesenchymal Stem Cells Promotes Microglial M2 Polarization to Alleviate Spinal Cord Injury

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
DPMSCs‐derived exosomal PSMD1 stimulates M2 polarization through the JAK2/STAT3 pathway. DPMSCs‐derived exosomal PSMD1 indirectly acts on NE‐4C cells. DPMSCs‐derived exosomal PSMD1 ameliorates SCI in a mouse model. ABSTRACT Background Exosomes derived from mesenchymal stem cells (MSCs) and their cargo contribute to the protective properties of MSCs in ...
Xiaohui Xing, Yuan Hao, Guanghui Zhang, Xiaoyang Xing, Hongfei Jia, Chenlong Liu, Xin Wang, Tao Li, Xueyuan Li, Yilei Xiao   +9 more
wiley   +1 more source

Genetic analysis of cis-enhancers associated with bone mineral density and periodontitis in the gene SOST.

PLoS ONE
A haplotype block at the sclerostin (SOST) gene correlates with bone mineral density (BMD) and increased periodontitis risk in smokers. Investigating the putative causal variants within this block, our study aimed to elucidate the impact of linked ...
Avneesh Chopra, Jiahui Song, January Weiner Rd, Dieter Beule, Arne S Schaefer   +4 more
doaj   +1 more source

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.
Resistance to venetoclax has become a critical bottleneck limiting its long‐term clinical benefits. A thorough understanding of the underlying resistance mechanisms and the development of novel strategies to overcome resistance are central to improving survival outcomes in elderly AML patients. Abstract To date, the treatment of acute myeloid leukaemia
Jinlin Zhang, Jile Liu, Mohan Zhao, Xiaoyu Zhang, Linlin Liu, Mengnan Li, Changze Cao, Rui Zhang, Mingfeng Zhao   +8 more
wiley   +1 more source

Multi-omics characterization of macrophage polarization-related features in osteoarthritis based on a machine learning computational framework

Heliyon
Background: OA imposes a heavy burden on patients and society in that its mechanism is still unclear, and there is a lack of effective targeted therapy other than surgery.
Ping Hu, Beining Li, Zhenyu Yin, Peng Peng, Jiangang Cao, Wanyu Xie, Liang Liu, Fujiang Cao, Bin Zhang   +8 more
doaj   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source