Results 81 to 90 of about 13,695 (188)

Mouse testicular macrophages can independently produce testosterone and are regulated by Cebpb

Biological Research
Abstract Background Testicular macrophages (TM) have long been recognized for their role in immune response within the testicular environment. However, their involvement in steroid hormone synthesis, particularly testosterone, has not been fully elucidated.
Nengliang Duan, Yuanshuai Ran, Huapei Wang, Ya Luo, Zhixiang Gao, Xingyu Lu, Fengmei Cui, Qiu Chen, Boxin Xue, Xiaolong Liu   +9 more
openaire   +3 more sources

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source

The Challenges and Opportunities of lncRNAs in Ovarian Cancer Research and Clinical Use [PDF]

, 2020
[Abstract] Ovarian cancer is one of the most lethal gynecological malignancies worldwide because it tends to be detected late, when the disease has already spread, and prognosis is poor.
Barreiro-Alonso, Aida, Cerdán, María Esperanza, Lamas, Mónica, Quindós-Varela, María, Rodríguez-Belmonte, Esther, Salamini-Montemurri, Martín, Vizoso-Vázquez, Ángel   +6 more
core   +1 more source

Chromosome 19 miRNA cluster and CEBPB expression specifically mark and potentially drive triple negative breast cancers.

PLoS ONE, 2018
Triple negative breast cancers (TNBCs) are known to express low PGR, ESR1, and ERBB2, and high KRT5, KRT14, and KRT17. However, the reasons behind the increased expressions of KRT5, KRT14, KRT17 and decreased expressions of PGR, ESR1, and ERBB2 in TNBCs ...
Goodwin G Jinesh, Elsa R Flores, Andrew S Brohl   +2 more
doaj   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Globularity and language-readiness: generating new predictions by expanding the set of genes of interest [PDF]

, 2014
This study builds on the hypothesis put forth in Boeckx and Benitez-Burraco (2014), according to which the developmental changes expressed at the levels of brain morphology and neural connectivity that resulted in a more globular braincase in our species
Antonio Benítez-Burraco, Cedric Boeckx   +1 more
core   +2 more sources

Microarray data analysis to identify crucial genes regulated by CEBPB in human SNB19 glioma cells [PDF]

World Journal of Surgical Oncology, 2016
Glioma is one of the most common primary malignancies in the brain or spine. The transcription factor (TF) CCAAT/enhancer binding protein beta (CEBPB) is important for maintaining the tumor initiating capacity and invasion ability. To investigate the regulation mechanism of CEBPB in glioma, microarray data GSE47352 was analyzed.GSE47352 was downloaded ...
Du, Chenghua, Pan, Pan, Jiang, Yan, Zhang, Qiuli, Bao, Jinsuo, Liu, Chang   +5 more
openaire   +2 more sources

Characterization of an Aging-Based Diagnostic Gene Signature and Molecular Subtypes With Diverse Immune Infiltrations in Atherosclerosis

Frontiers in Molecular Biosciences, 2022
Objective: Advancing age is a major risk factor of atherosclerosis (AS). Nevertheless, the mechanism underlying this phenomenon remains indistinct. Herein, this study conducted a comprehensive analysis of the biological implications of aging-related ...
Lei Zhao, Fengfeng Lv, Ye Zheng, Liqiu Yan, Xufen Cao   +4 more
doaj   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

Advanced NanoBiomed Research, Volume 6, Issue 5, May 2026.
An injectable CNC–PNIPAM hydrogel is developed for intrauterine co‐delivery of levonorgestrel and botropase. This platform reprograms uterine natural killer cells toward an immune–tolerant phenotype and enhances endometrial receptivity marker expression. The results demonstrate a promising strategy to counteract endometriosis–associated infertility and
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun Wang   +9 more
wiley   +1 more source